公开(公告)号：WO0039279A9

公开(公告)日：2001-10-04

申请号：PCT/US9931169

申请日：1999-12-30

Applicant: SYNAPTIC PHARMA CORP ,  SALON JOHN A ,  LAZ THOMAS M ,  NAGORNY RAISA ,  WILSON AMY E

Inventor： SALON JOHN A ,  LAZ THOMAS M ,  NAGORNY RAISA ,  WILSON AMY E

IPC: G01N33/50 ,  A61K31/7088 ,  A61K45/00 ,  A61K48/00 ,  A61M1/36 ,  A61P1/00 ,  A61P3/10 ,  A61P3/12 ,  A61P5/06 ,  A61P9/00 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P15/00 ,  A61P21/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/06 ,  A61P25/36 ,  A61P37/00 ,  A61P43/00 ,  C07K14/72 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04 ,  C12N15/12 ,  C12N15/63

CPC classification number: A61M1/3621 ,  C07K14/72

Abstract: This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense aligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

Abstract translation: 本发明提供编码人MCH1受体的纯化的人MCH1受体的核酸，纯化的人MCH1受体，包含分离的编码人MCH1受体的核酸的载体，包含该载体的细胞，针对人MCH1受体的抗体，用于检测核酸的核酸探针 编码人MCH1受体的酸，与编码人MCH1受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变型人MCH1受体的DNA的转基因非人动物，分离人MCH1受体的方法，治疗异常的方法 与人MCH1受体的活性相关，以及确定化合物与哺乳动物MCH1受体结合的方法。

公开(公告)号：WO0039279A2

公开(公告)日：2000-07-06

申请号：PCT/US9931169

申请日：1999-12-30

Applicant: SYNAPTIC PHARMA CORP ,  SALON JOHN A ,  LAZ THOMAS M ,  NAGORNY RAISA ,  WILSON AMY E

Inventor： SALON JOHN A ,  LAZ THOMAS M ,  NAGORNY RAISA ,  WILSON AMY E

IPC: G01N33/50 ,  A61K31/7088 ,  A61K45/00 ,  A61K48/00 ,  A61M1/36 ,  A61P1/00 ,  A61P3/10 ,  A61P3/12 ,  A61P5/06 ,  A61P9/00 ,  A61P9/12 ,  A61P11/00 ,  A61P11/06 ,  A61P15/00 ,  A61P21/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/06 ,  A61P25/36 ,  A61P37/00 ,  A61P43/00 ,  C07K14/72 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N

CPC classification number: A61M1/3621 ,  C07K14/72

Abstract: This invention provides an isolated nucleic acid encoding a human MCH1 receptor, a purified human MCH1 receptor, vectors comprising isolated nucleic acid encoding a human MCH1 receptor, cells comprising such vectors, antibodies directed to a human MCH1 receptor, nucleic acid probes useful for detecting nucleic acid encoding human MCH1 receptors, antisense aligonucleotides complementary to unique sequences of nucleic acid encoding human MCH1 receptors, transgenic, nonhuman animals which express DNA encoding a normal or mutant human MCH1 receptor, methods of isolating a human MCH1 receptor, methods of treating an abnormality that is linked to the activity of a human MCH1 receptor, as well as methods of determining binding of compounds to mammalian MCH1 receptors.

Abstract translation: 本发明提供编码人MCH1受体的分离核酸，纯化的人MCH1受体，包含编码人MCH1受体的分离核酸的载体，包含此类载体的细胞，针对人MCH1受体的抗体，用于检测核酸的核酸探针 编码人MCH1受体的酸，与编码人MCH1受体的核酸的独特序列互补的反义寡核苷酸，表达编码正常或突变人MCH1受体的DNA的转基因非人动物，分离人MCH1受体的方法，治疗异常 与人MCH1受体的活性有关，以及确定化合物与哺乳动物MCH1受体结合的方法。