公开(公告)号：WO2007089601A3

公开(公告)日：2007-08-09

申请号：PCT/US2007/002199

申请日：2007-01-26

Applicant: BIOGEN IDEC MA INC. ,  LEE, Daniel, H.S. ,  WEN, Dingyi ,  PEPINSKY, R., Blake ,  RELTON, Jane, K. ,  WANG, Xinzhong ,  LUGOVSKOY, Alexey ,  MEIER, Werner ,  GARBER, Ellen, A. ,  SILVIAN, Laura ,  WEINREB, Paul, H.

Inventor： LEE, Daniel, H.S. ,  WEN, Dingyi ,  PEPINSKY, R., Blake ,  RELTON, Jane, K. ,  WANG, Xinzhong ,  LUGOVSKOY, Alexey ,  MEIER, Werner ,  GARBER, Ellen, A. ,  SILVIAN, Laura ,  WEINREB, Paul, H.

IPC: A61K39/395 ,  A61K38/17 ,  C07K16/28 ,  C07K14/705

Abstract: Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.

公开(公告)号：WO2006124627A2

公开(公告)日：2006-11-23

申请号：PCT/US2006/018484

申请日：2006-05-12

Applicant: BIOGEN IDEC MA INC. ,  THE UNIVERSITY OF HONG KONG ,  LEE, Daniel H.S. ,  SAH, Dinah W.Y. ,  SO, Kwok Fai ,  WU, Wutian

Inventor： LEE, Daniel H.S. ,  SAH, Dinah W.Y. ,  SO, Kwok Fai ,  WU, Wutian

IPC: A61K39/395 ,  C07K16/46

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K2317/55 ,  C07K2317/76

Abstract: The invention provides methods for treating conditions of the eye involving death or degeneration of retinal ganglion cells, including glaucoma, by the administration of Nogo receptor-1 antagonists.

Abstract translation: 本发明提供了通过施用Nogo受体-1拮抗剂来治疗涉及视网膜神经节细胞（包括青光眼）的死亡或退化的眼睛病症的方法。

公开(公告)号：WO2007098283A2

公开(公告)日：2007-08-30

申请号：PCT/US2007/005078

申请日：2007-02-27

Applicant: BIOGEN IDEC MA INC. ,  LEE, Daniel, H.S. ,  ROSSOMANDO, Anthony ,  WEINREB, Paul, H.

Inventor： LEE, Daniel, H.S. ,  ROSSOMANDO, Anthony ,  WEINREB, Paul, H.

IPC: A61K38/18

CPC classification number: A61K38/17

Abstract: The invention provides methods of treating diseases, disorders, injuries, or conditions involving modulating neurite outgrowth and/or survival, and axonal regeneration including CNS disorders, stroke, or spinal injury, by administration of a MAIF receptor complex molecule antagonist and a neurotrophic factor.

Abstract translation: 本发明提供了通过施用MAIF受体复合物分子拮抗剂和神经营养因子来治疗涉及调节神经突生长和/或存活的疾病，病症，损伤或病症以及包括CNS病症，中风或脊髓损伤的轴突再生的方法。