Abstract:
Methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. Improved LTBR-Ig fusion proteins, and pharmaceutical compositions thereof, are also described.
Abstract:
The invention provides methods and compositions for separating impurities during the manufacture of immunoglobulin (Ig) fusion proteins. Examples of impurities which may be removed in accordance with the methods of the invention include inactive forms of the Ig fusion protein and/or aggregates.
Abstract:
Eine Einrichtung zum Entfernen von Feststoffpartikeln aus dem im Primärkreis eines Kernreaktors, insbesondere eines Siedewasserkernreaktors, umgewälzten Kühlmedium (K) ist in ihren geometrischen Abmessungen und Formen derart gestaltet, dass sie wie ein für diesen Kernreaktor konfiguriertes Brennelement und an Stelle eines solchen Brennelementes in eine leere Brennelementposition des Reaktorkerns (40) des Kernreaktors einsetzbar ist.
Abstract:
The invention relates to methods for the expression of high yields of the form protein-immunoglobulin fusions having high affinity binding to its ligand, by culturing hosts transformed with DNA encoding the desired fusions in a cultutre system at a low temperature thereby minimizing the amount of misfolded or misbridged protein forms. Said host cells may be transformed mammalian, insect, yeast or bacterial cells. The protein-immunoglobulin fusion may comprises a member of the TNF or TNF-receptor family, such as lymphotoxin-beta or lymphotoxin-beta receptor. The invention also relates to pharmaceutical composition comprising said protein-immunoglobulin fusions.
Abstract:
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
Abstract:
Methods of treating disease with soluble inhibitors of the lymphotoxin pathway having improved properties. Improved LTBR-Ig fusion proteins, and pharmaceutical compositions thereof, are also described.
Abstract:
Disclosed are immunogenic Nogo receptor-1 polypeptides, Nogo receptor-1 antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof and nucleic acids encoding the same. Also disclosed are Nogo receptor antagonist polynucleotides. Also disclosed are compositions comprising, and methods for making and using, such Nogo receptor antibodies, antigen-binding fragments thereof, soluble Nogo receptors and fusion proteins thereof, nucleic acids encoding the same and antagonist polynucleotides.
Abstract:
Disclosed is a fuel element for a boiling water reactor, comprising a plurality of fuel rods (1 to 3) which are mounted in a plurality of spacers (11 to 18) placed at a distance from each other in the axial direction of the fuel element. At least one (1, 2) of said fuel rods has a reduced length. Deflecting element (48) are arranged at least in the top portion (B) of the fuel element in order to improve dryout behavior. The inventive fuel element also comprises means for reducing the loss of pressure caused in said portion (B) by the deflecting elements so as to improve thermohydraulic stability and shutdown behavior.
Abstract:
In order to reduce the flow resistance of a coolant flowing through a passage (63) in the support plate (64) of a boiling water reactor and entering the transition piece (50) at the lower end of a fuel assembly resting on said support plate (64), the lower rim (60) of the transition piece (50) forms a conically tapered surface which fits into a corresponding conical counter-surface (62) at the upper edge of said passage (63). The lower rim (60) of the transition piece (50) forms a circular inlet which is concentric with the passage (63) and has a size equal or slightly larger than the passage opening. Fingers (70) protruding laterally into said opening and extending down into said passage (63) are used to center the low rim (60) within the passage (63). Additionally, the end caps (90) of the fuel rods may be stream-lined and the lower tie plate (53) of the fuel assembly may be spaced apart from the inner surface of a fuel channel (52) by a plurality of ribs (86) which form a plurality of peripheral through holes (86') on each of the four inner surfaces (84) of the rectangular fuel channel (52).
Abstract:
In a boiling-water fuel element with a central coolant pipe (WR) as the backbone of the bearing frame, upper end section (WE) of the coolant pipe (WR) becomes a relatively slim linking stud (4) engaging through an aperture in the upper rod holder (1) and secured there. Thus the upper end section (WE) lies at the upper edge of the active zone (AZ) and the coolant outlets of the coolant pipe (WR) take the form of passages (8) which are axial or run inwards to the linking stud. This provides good flow conditions, especially low pressure losses, in the upper part of the fuel element.