公开(公告)号：WO2009011871A2

公开(公告)日：2009-01-22

申请号：PCT/US2008008690

申请日：2008-07-15

Applicant: AMGEN INC ,  ALLEN JOHN G ,  BOURBEAU MATTHEW P ,  DOMINGUEZ CELIA ,  FOTSCH CHRISTOPHER H ,  HAN NIANHE ,  HONG FANG-TSAO ,  HUANG XIN ,  LEE MATTHEW R ,  LIU QINGYIAN ,  REICHELT ANDREAS ,  TADESSE SEIFU ,  WANG XIANGHONG ,  YAO GUOMIN ,  YUAN CHESTER CHENGUANG ,  ZENG QINGPING

Inventor： ALLEN JOHN G ,  BOURBEAU MATTHEW P ,  DOMINGUEZ CELIA ,  FOTSCH CHRISTOPHER H ,  HAN NIANHE ,  HONG FANG-TSAO ,  HUANG XIN ,  LEE MATTHEW R ,  LIU QINGYIAN ,  REICHELT ANDREAS ,  TADESSE SEIFU ,  WANG XIANGHONG ,  YAO GUOMIN ,  YUAN CHESTER CHENGUANG ,  ZENG QINGPING

IPC: C07D471/02 ,  A61K31/433 ,  A61P29/00 ,  A61P35/00 ,  C07D285/125 ,  C07D285/135

CPC classification number: C07D285/135 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。

公开(公告)号：WO2007084391A3

公开(公告)日：2007-07-26

申请号：PCT/US2007/000871

申请日：2007-01-11

Applicant: AMGEN INC. ,  ZENG, Qingping ,  ALLEN, John G. ,  BOURBEAU, Matthew P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher H. ,  HAN, Nianhe ,  HONG, Fang-Tsao ,  HUANG, Xin ,  LEE, Matthew R. ,  LI, Aiwen ,  LIU, Qingyian ,  RIDER, James T. ,  TADESSE, Seifu ,  TASKER, Andrew S. ,  VISWANADHAN, Vellarkad N. ,  WANG, Xianghong ,  WEILER, Kurt E. ,  WOHLHIETER, George E. ,  YAO, Guomin ,  YUAN, Chester Chenguang

Inventor： ZENG, Qingping ,  ALLEN, John G. ,  BOURBEAU, Matthew P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher H. ,  HAN, Nianhe ,  HONG, Fang-Tsao ,  HUANG, Xin ,  LEE, Matthew R. ,  LI, Aiwen ,  LIU, Qingyian ,  RIDER, James T. ,  TADESSE, Seifu ,  TASKER, Andrew S. ,  VISWANADHAN, Vellarkad N. ,  WANG, Xianghong ,  WEILER, Kurt E. ,  WOHLHIETER, George E. ,  YAO, Guomin ,  YUAN, Chester Chenguang

IPC: C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  C07D471/04 ,  C07D277/54 ,  C07D495/04 ,  C07D277/42 ,  A61K31/427 ,  A61P35/00

Abstract: The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

公开(公告)号：WO2009011871A3

公开(公告)日：2009-01-22

申请号：PCT/US2008/008690

申请日：2008-07-15

Applicant: AMGEN INC. ,  ALLEN, John, G. ,  BOURBEAU, Matthew, P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  HONG, Fang-tsao ,  HUANG, Xin ,  LEE, Matthew, R. ,  LIU, Qingyian ,  REICHELT, Andreas ,  TADESSE, Seifu ,  WANG, Xianghong ,  YAO, Guomin ,  YUAN, Chester Chenguang ,  ZENG, Qingping

Inventor： ALLEN, John, G. ,  BOURBEAU, Matthew, P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  HONG, Fang-tsao ,  HUANG, Xin ,  LEE, Matthew, R. ,  LIU, Qingyian ,  REICHELT, Andreas ,  TADESSE, Seifu ,  WANG, Xianghong ,  YAO, Guomin ,  YUAN, Chester Chenguang ,  ZENG, Qingping

IPC: C07D471/02 ,  C07D285/135 ,  C07D285/125 ,  A61K31/433 ,  A61P35/00 ,  A61P29/00

Abstract: The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

公开(公告)号：WO2007084391A2

公开(公告)日：2007-07-26

申请号：PCT/US2007000871

申请日：2007-01-11

Applicant: AMGEN INC ,  ZENG QINGPING ,  ALLEN JOHN G ,  BOURBEAU MATTHEW P ,  DOMINGUEZ CELIA ,  FOTSCH CHRISTOPHER H ,  HAN NIANHE ,  HONG FANG-TSAO ,  HUANG XIN ,  LEE MATTHEW R ,  LI AIWEN ,  LIU QINGYIAN ,  RIDER JAMES T ,  TADESSE SEIFU ,  TASKER ANDREW S ,  VISWANADHAN VELLARKAD N ,  WANG XIANGHONG ,  WEILER KURT E ,  WOHLHIETER GEORGE E ,  YAO GUOMIN ,  YUAN CHESTER CHENGUANG

Inventor： ZENG QINGPING ,  ALLEN JOHN G ,  BOURBEAU MATTHEW P ,  DOMINGUEZ CELIA ,  FOTSCH CHRISTOPHER H ,  HAN NIANHE ,  HONG FANG-TSAO ,  HUANG XIN ,  LEE MATTHEW R ,  LI AIWEN ,  LIU QINGYIAN ,  RIDER JAMES T ,  TADESSE SEIFU ,  TASKER ANDREW S ,  VISWANADHAN VELLARKAD N ,  WANG XIANGHONG ,  WEILER KURT E ,  WOHLHIETER GEORGE E ,  YAO GUOMIN ,  YUAN CHESTER CHENGUANG

IPC: C07D417/04 ,  C07D277/42 ,  C07D277/54 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及式（I）和式（II）的噻唑化合物及其组合物，其用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。