公开(公告)号：WO2007048070A3

公开(公告)日：2007-07-12

申请号：PCT/US2006041562

申请日：2006-10-23

Applicant: AMGEN INC ,  GERMAIN JULIE ,  ASKEW BENNY C JR ,  BAUER DAVID ,  CHOQUETTE DEBORAH ,  DIPIETRO LUCIAN V ,  GRACEFFA RUSSELL ,  HARMANAGE JEAN-CHRISTOPHE ,  HUANG QI ,  KIM JOSEPH L ,  LA DANIEL ,  LI AIWEN ,  NISHIMURA NOBUKO ,  NOMACK RANA ,  PATEL VINOD ,  POTASHMAN MICHELE ,  RIAHI BABAK ,  STORZ THOMAS ,  VAN DER PLAS SIMON ,  YANG KEVIN ,  YUAN CHESTER C

Inventor： GERMAIN JULIE ,  ASKEW BENNY C JR ,  BAUER DAVID ,  CHOQUETTE DEBORAH ,  DIPIETRO LUCIAN V ,  GRACEFFA RUSSELL ,  HARMANAGE JEAN-CHRISTOPHE ,  HUANG QI ,  KIM JOSEPH L ,  LA DANIEL ,  LI AIWEN ,  NISHIMURA NOBUKO ,  NOMACK RANA ,  PATEL VINOD ,  POTASHMAN MICHELE ,  RIAHI BABAK ,  STORZ THOMAS ,  VAN DER PLAS SIMON ,  YANG KEVIN ,  YUAN CHESTER C

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract translation: 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：WO2006036664A1

公开(公告)日：2006-04-06

申请号：PCT/US2005/033659

申请日：2005-09-19

Applicant: AMGEN INC. ,  ASKEW, JR, Ben, C. ,  AYA, Toshihiro ,  BISWAS, Kaustav ,  CAI, Guolin ,  CHEN, Jian, J. ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  HUMAN, Jason, Brooks ,  LI, Aiwen ,  LIU, Qingyian ,  PETERKIN, Tanya ,  QIAN, Wenyuan ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ZHU, Jiawang

Inventor： ASKEW, JR, Ben, C. ,  AYA, Toshihiro ,  BISWAS, Kaustav ,  CAI, Guolin ,  CHEN, Jian, J. ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  HUMAN, Jason, Brooks ,  LI, Aiwen ,  LIU, Qingyian ,  PETERKIN, Tanya ,  QIAN, Wenyuan ,  RIAHI, Babak ,  YUAN, Chester, Chenguang ,  ZHU, Jiawang

IPC: C07C311/19 ,  C07D207/48 ,  C07D211/08 ,  A61K31/18 ,  A61K31/40 ,  A61K31/445

CPC classification number: C07D207/26 ,  C07C311/19 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2602/10 ,  C07D211/38 ,  C07D215/36 ,  C07D233/24 ,  C07D243/08 ,  C07D275/06 ,  C07D281/02 ,  C07D291/08 ,  C07D295/135 ,  C07D311/68

Abstract: This invention is in the field of pharmaceutical agents and specifically relates to compounds, compositions, uses and methods for treating inflammation-related disorders, including pain.

Abstract translation: 本发明涉及药剂领域，具体涉及用于治疗炎症相关疾病（包括疼痛）的化合物，组合物，用途和方法。

公开(公告)号：WO2007084391A3

公开(公告)日：2007-07-26

申请号：PCT/US2007/000871

申请日：2007-01-11

Applicant: AMGEN INC. ,  ZENG, Qingping ,  ALLEN, John G. ,  BOURBEAU, Matthew P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher H. ,  HAN, Nianhe ,  HONG, Fang-Tsao ,  HUANG, Xin ,  LEE, Matthew R. ,  LI, Aiwen ,  LIU, Qingyian ,  RIDER, James T. ,  TADESSE, Seifu ,  TASKER, Andrew S. ,  VISWANADHAN, Vellarkad N. ,  WANG, Xianghong ,  WEILER, Kurt E. ,  WOHLHIETER, George E. ,  YAO, Guomin ,  YUAN, Chester Chenguang

Inventor： ZENG, Qingping ,  ALLEN, John G. ,  BOURBEAU, Matthew P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher H. ,  HAN, Nianhe ,  HONG, Fang-Tsao ,  HUANG, Xin ,  LEE, Matthew R. ,  LI, Aiwen ,  LIU, Qingyian ,  RIDER, James T. ,  TADESSE, Seifu ,  TASKER, Andrew S. ,  VISWANADHAN, Vellarkad N. ,  WANG, Xianghong ,  WEILER, Kurt E. ,  WOHLHIETER, George E. ,  YAO, Guomin ,  YUAN, Chester Chenguang

IPC: C07D417/04 ,  C07D417/14 ,  C07D513/04 ,  C07D471/04 ,  C07D277/54 ,  C07D495/04 ,  C07D277/42 ,  A61K31/427 ,  A61P35/00

Abstract: The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

公开(公告)号：WO2007048070A2

公开(公告)日：2007-04-26

申请号：PCT/US2006/041562

申请日：2006-10-23

Applicant: AMGEN INC. ,  GERMAIN, Julie ,  ASKEW, Benny, C., Jr. ,  BAUER, David ,  CHOQUETTE, Deborah ,  DIPIETRO, Lucian, V. ,  GRACEFFA, Russell ,  HARMANAGE, Jean-Christophe ,  HUANG, Qi ,  KIM, Joseph, L. ,  LA, Daniel ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMACK, Rana ,  PATEL, Vinod ,  POTASHMAN, Michele ,  RIAHI, Babak ,  STORZ, Thomas ,  VAN DER PLAS, Simon ,  YANG, Kevin ,  YUAN, Chester, C.

Inventor： GERMAIN, Julie ,  ASKEW, Benny, C., Jr. ,  BAUER, David ,  CHOQUETTE, Deborah ,  DIPIETRO, Lucian, V. ,  GRACEFFA, Russell ,  HARMANAGE, Jean-Christophe ,  HUANG, Qi ,  KIM, Joseph, L. ,  LA, Daniel ,  LI, Aiwen ,  NISHIMURA, Nobuko ,  NOMACK, Rana ,  PATEL, Vinod ,  POTASHMAN, Michele ,  RIAHI, Babak ,  STORZ, Thomas ,  VAN DER PLAS, Simon ,  YANG, Kevin ,  YUAN, Chester, C.

IPC: C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Abstract translation: 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：WO2006012374A1

公开(公告)日：2006-02-02

申请号：PCT/US2005/025800

申请日：2005-07-20

Applicant: AMGEN INC. ,  YUAN, Chester Chenguang ,  YANG, Kevin ,  VANDERPLAS, Simon ,  RIAHI, Babak ,  POTASHMAN, Michele ,  PATEL, Vinod F. ,  NOMAK, Rana ,  LI, Aiwen ,  HUANG, Qi ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C.

Inventor： YUAN, Chester Chenguang ,  YANG, Kevin ,  VANDERPLAS, Simon ,  RIAHI, Babak ,  POTASHMAN, Michele ,  PATEL, Vinod F. ,  NOMAK, Rana ,  LI, Aiwen ,  HUANG, Qi ,  HARMANGE, Jean-Christophe ,  ASKEW, JR., Benny C.

IPC: C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D217/02 ,  C07D403/12 ,  C07D417/14 ,  C07D471/04 ,  A61K31/443 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4725 ,  A61P35/00

CPC classification number: C07D401/12 ,  C07D217/02 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: The present invention provides classes of compounds, including-their pharmaceutically acceptable derivatives, useful for treating angiogenesis and related diseases such as cancer. Formula I and II wherein R is a 9- or 10-membered heterocyclyl ring selected from 7-isoquinolinyl,..2-methyl-3-oxo-2,3-dihydroindazol-6-yl, [1,6]-naphthydrin-3-yl, [1,7]-naphthydrin-2-yl, 1-oxo-2,3-dihydrobenzofuran-4-yl, 3-oxo - 2,3 - dihydrobenzofuran-5-yl, dihydro-benzodioxinyl, 6-quinazolinyl, 2-amino-6-quinazolinyl, 4-methylamino-6-quinazolinyl, 2,4-diamino-6 quinazolinyl, 3-oxo-3,4 - dihydro-1,4-benzoxazin-6-yl, 2,2 - difluoro-l;3-benzodioxol-5-yl and 2,2,3,3 tetrafluoro-2,3-dihydro-l,4-benzodioxin-6-yl, each of which is optionally substituted with one or more substituents selected from halo, haloakyl, C 1-6 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, N-dimethylamino-C 1-6 -alkyl, N-dimethylamino-C 1-6 -alkoxy, amino, alkyl-carbonylamino, morpholino-sulfonyl, amino-sulfonyl, oxazolyl, pyrrolyl, 4 morpholinyl, carboxyl, cyano, and acetyl; wherein R 1 in formula I is selected from unsubstituted or substituted phenyl, 5-6 membered heteroaryl, 9-10 membered bicyclic heterocyclyl and 11-14 membered tricyclic heterocyclyl, and R 1 in formula II is selected from specific bicyclic heterocycles.

Abstract translation: 本发明提供了可用于治疗血管发生和相关疾病如癌症的化合物类，包括其药学上可接受的衍生物。 式I和II其中R是选自7-异喹啉基，2-甲基-3-氧代-2,3-二氢吲唑-6-基，[1,6] - 萘啶-2-酮的9-或10-元杂环基环， 吡啶-3-基，[1,7]萘啶-2-基，1-氧代-2,3-二氢苯并呋喃-4-基，3-氧代-2,3-二氢 - 二氢苯并二氧杂环戊烯基，6-喹唑啉基，2-氨基-6-喹唑啉基，4-甲基氨基-6-喹唑啉基，2,4-二氨基-6-喹唑啉基，3-氧代-3,4-二氢苯并呋喃-5-基 二氢-1,4-苯并恶嗪-6-基，2,2 - 二氟-1,3-苯并间二氧杂环戊烯-5-基和2,2,3,3-四氟 - 2,3-二氢-1,4-苯并二恶英-6-基，其各自任选被一个或多个选自卤素，卤代烷基，C 1-6烷基，C 1 -C 6烷基， 2-8链烯基，C 2-8炔基，N-二甲基氨基-C 1-6 - 烷基，N-二甲基氨基-C1- 6 - 烷氧基，氨基，烷基 - 羰基氨基，吗啉代 - 磺酰基，氨基 - 磺酰基，恶唑基，吡咯基，吗啉基，羧基，氰基和乙酰基。 其中式I中的R 1选自未取代或取代的苯基，5-6元杂芳基，9-10元双环杂环基和11-14元三环杂环基，R 1， 式Ⅱ中选自具体的双环杂环。

公开(公告)号：WO2005116002A3

公开(公告)日：2005-12-08

申请号：PCT/US2005/018081

申请日：2005-05-24

Applicant: AMGEN INC. ,  BIOVITRUM AB ,  HENRIKSSON, Martin ,  HOMAN, Evert ,  JOHANSSON, Lars ,  VALLGARDA, Jerk ,  WILLIAMS, Meredith ,  BERCOT, Eric ,  FOTSCH, Christopher, H. ,  LI, Aiwen ,  CAI, Guolin ,  HUNGATE, Randall, W. ,  YUAN, Chester, Chenguang ,  TEGLEY, Chirstopher ,  ST. JEAN, David ,  HAN, Nianhe ,  HUANG, Qi ,  LIU, Qingyian ,  BARTBERGER, Michael, D. ,  MONIZ, George, A. ,  FRIZZLE, Matthew, J.

Inventor： HENRIKSSON, Martin ,  HOMAN, Evert ,  JOHANSSON, Lars ,  VALLGARDA, Jerk ,  WILLIAMS, Meredith ,  BERCOT, Eric ,  FOTSCH, Christopher, H. ,  LI, Aiwen ,  CAI, Guolin ,  HUNGATE, Randall, W. ,  YUAN, Chester, Chenguang ,  TEGLEY, Chirstopher ,  ST. JEAN, David ,  HAN, Nianhe ,  HUANG, Qi ,  LIU, Qingyian ,  BARTBERGER, Michael, D. ,  MONIZ, George, A. ,  FRIZZLE, Matthew, J.

IPC: C07D277/54 ,  C07D263/48 ,  A61K31/42 ,  A61K31/426 ,  A61P3/04 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P19/10 ,  A61P31/12 ,  A61P29/00 ,  A61P25/28 ,  A61P25/24

Abstract: The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

公开(公告)号：WO2007084391A2

公开(公告)日：2007-07-26

申请号：PCT/US2007000871

申请日：2007-01-11

Applicant: AMGEN INC ,  ZENG QINGPING ,  ALLEN JOHN G ,  BOURBEAU MATTHEW P ,  DOMINGUEZ CELIA ,  FOTSCH CHRISTOPHER H ,  HAN NIANHE ,  HONG FANG-TSAO ,  HUANG XIN ,  LEE MATTHEW R ,  LI AIWEN ,  LIU QINGYIAN ,  RIDER JAMES T ,  TADESSE SEIFU ,  TASKER ANDREW S ,  VISWANADHAN VELLARKAD N ,  WANG XIANGHONG ,  WEILER KURT E ,  WOHLHIETER GEORGE E ,  YAO GUOMIN ,  YUAN CHESTER CHENGUANG

Inventor： ZENG QINGPING ,  ALLEN JOHN G ,  BOURBEAU MATTHEW P ,  DOMINGUEZ CELIA ,  FOTSCH CHRISTOPHER H ,  HAN NIANHE ,  HONG FANG-TSAO ,  HUANG XIN ,  LEE MATTHEW R ,  LI AIWEN ,  LIU QINGYIAN ,  RIDER JAMES T ,  TADESSE SEIFU ,  TASKER ANDREW S ,  VISWANADHAN VELLARKAD N ,  WANG XIANGHONG ,  WEILER KURT E ,  WOHLHIETER GEORGE E ,  YAO GUOMIN ,  YUAN CHESTER CHENGUANG

IPC: C07D417/04 ,  C07D277/42 ,  C07D277/54 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

CPC classification number: C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D513/04

Abstract: The invention relates to thiazole compounds of Formula (I) and Formula (II) and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Abstract translation: 本发明涉及式（I）和式（II）的噻唑化合物及其组合物，其用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

公开(公告)号：WO2007061661A2

公开(公告)日：2007-05-31

申请号：PCT/US2006043951

申请日：2006-11-13

Applicant: AMGEN INC ,  BIOVITRUM AB ,  HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC A ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHRISTOPHER ,  ST JEAN DAVID J JR ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBEGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J ,  MARSHALL TERESA L

Inventor： HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC A ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHRISTOPHER ,  ST JEAN DAVID J JR ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBEGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J ,  MARSHALL TERESA L

IPC: C07D277/54 ,  A61K31/426 ,  A61K31/427 ,  C07D277/60 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D277/54 ,  C07D277/60 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-ß-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11- ß-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及噻唑啉酮以及包含该化合物的药物组合物，以及该化合物用于治疗与人类11-羟基类固醇脱氢酶1型酶有关的病症的用途的方法以及用于制备作用于 人类11-羟基类固醇脱氢酶1型酶。

公开(公告)号：WO0107436A3

公开(公告)日：2001-08-23

申请号：PCT/IB0001156

申请日：2000-07-26

Applicant: AVENTIS PHARM PROD INC ,  EWING WILLIAM R ,  BECKER MICHAEL R ,  CHOI SLEDESKI YONG MI ,  PAULS HEINZ W ,  HE WEI ,  CONDON STEPHEN M ,  DAVIS RODERICK S ,  HANNEY BARBARA A ,  SPADA ALFRED P ,  BURNS CHRISTOPHER J ,  JIANG JOHN Z ,  LI AIWEN ,  MYERS MICHAEL R ,  LAU WAN F ,  POLI GREGORY B

Inventor： EWING WILLIAM R ,  BECKER MICHAEL R ,  CHOI-SLEDESKI YONG MI ,  PAULS HEINZ W ,  HE WEI ,  CONDON STEPHEN M ,  DAVIS RODERICK S ,  HANNEY BARBARA A ,  SPADA ALFRED P ,  BURNS CHRISTOPHER J ,  JIANG JOHN Z ,  LI AIWEN ,  MYERS MICHAEL R ,  LAU WAN F ,  POLI GREGORY B

IPC: C07D241/08 ,  A61K31/495 ,  A61K31/496 ,  A61K31/498 ,  A61K31/502 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P7/02 ,  A61P9/02 ,  A61P9/04 ,  A61P9/10 ,  A61P19/02 ,  A61P25/28 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D491/04

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D409/14 ,  C07D471/04 ,  Y02P20/582

Abstract: This invention is directed to oxoazaheterocyclyl compounds which inhibit Factor Xa, to oxoazaheterocyclyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.

公开(公告)号：WO2005116002A2

公开(公告)日：2005-12-08

申请号：PCT/US2005018081

申请日：2005-05-24

Applicant: AMGEN INC ,  BIOVITRUM AB ,  HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHIRSTOPHER ,  ST JEAN DAVID ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBERGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J

Inventor： HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHIRSTOPHER ,  ST JEAN DAVID ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBERGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J

IPC: A61K31/42 ,  A61K31/426 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P19/10 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  C07D20060101 ,  C07D263/48 ,  C07D277/42 ,  C07D277/54 ,  C07D277/60 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  C07F7/18

CPC classification number: C07D417/06 ,  C07D263/34 ,  C07D263/48 ,  C07D275/03 ,  C07D277/42 ,  C07D277/54 ,  C07D277/60 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  C07F7/1856

Abstract: The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R , R , R , R , R , R , R , X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及具有式（I），（II），（III）或（IV）：（I）（II），（III）或（IV））的化合物，其中R 1，R 2 R 3，R 4，R 5，R 6，R 7，X 7和Z如本文所定义，并且还涉及包含该化合物的药物组合物，以及使用方法 的用于治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的疾病的化合物和用于制备作用于人类11-β-羟基类固醇脱氢酶1型酶的药物。