公开(公告)号：WO2012092880A1

公开(公告)日：2012-07-12

申请号：PCT/CN2012/070122

申请日：2012-01-07

Applicant: CENTAURUS BIOPHARMA CO., LTD. ,  XIAO, Dengming ,  CHENG, Liang ,  LIU, Xijie ,  HU, Yuandong ,  XU, Xinhe ,  LIU, Zhihua ,  ZHANG, Lipeng ,  WU, Wei ,  WANG, Shulong ,  SHEN, Yu ,  LI, Gen ,  WANG, Yin ,  ZHAO, Sheng ,  LI, Chonglong ,  TANG, Jia ,  YU, Honghao

Inventor： XIAO, Dengming ,  CHENG, Liang ,  LIU, Xijie ,  HU, Yuandong ,  XU, Xinhe ,  LIU, Zhihua ,  ZHANG, Lipeng ,  WU, Wei ,  WANG, Shulong ,  SHEN, Yu ,  LI, Gen ,  WANG, Yin ,  ZHAO, Sheng ,  LI, Chonglong ,  TANG, Jia ,  YU, Honghao

IPC: C07D487/04 ,  A61K31/505 ,  A61P35/00 ,  A61P29/00 ,  A61P31/00 ,  A61P37/02

CPC classification number: C07D487/04 ,  A61K31/4523 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D493/12

Abstract: The invention relates to a novel class of 2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as a FAK and/or Pyk2 inhibitor, to a process for their preparation, and to a composition thereof, as well as to use of the compounds for the inhibiting FAK and/or Pyk2 and method for the treatment of a FAK and/ or Pyk2 mediated disorder or disease.

Abstract translation: 本发明涉及一种新型的作为FAK和/或Pyk2抑制剂的2,4-二氨基-6,7-二氢-5H-吡咯并[2,3]嘧啶衍生物，其制备方法和组合物 以及该化合物用于抑制FAK和/或Pyk2的方法和用于治疗FAK和/或Pyk2介导​​的病症或疾病的方法。