公开(公告)号：WO2010061191A1

公开(公告)日：2010-06-03

申请号：PCT/GB2009/002763

申请日：2009-11-26

Applicant: OXFORD INSTRUMENTS MOLECULAR BIOTOOLS LIMITED ,  LOHMAN, Joost, A., B. ,  ENGLEFIELD, Mark, P.

Inventor： LOHMAN, Joost, A., B. ,  ENGLEFIELD, Mark, P.

IPC: G01R33/30 ,  G01R33/62

CPC classification number: G01R33/62 ,  G01R33/282 ,  G01R33/305 ,  G01R33/307 ,  G01R33/3815

Abstract: DNP apparatus comprises: a cryostat (1) within which is located a superconducting magnet (3) and defining a bore (2) having opposite inlet and outlet ends and surrounded by the magnet. A sample positioning device (14) is provided for insertion into the inlet end of the bore (2) to locate a sample at an irradiation position coupled to a microwave source. A dissolution dock (20) is located at the outlet end of the bore (2) to which the sample positioning device (14) is moved following DNP of a sample; and a solvent supply system conveys heated solvent under pressure, without passing through the bore (2), to a sample at the dissolution dock (20), and conveys the dissolved, polarised sample to NMR apparatus. The conduits of the solvent supply system extend to the dissolution position without passing through that part of the cryostat bore through which the sample positioning device is inserted.

Abstract translation: DNP设备包括：低温恒温器（1），其中位于超导磁体（3）中并且限定具有相对的入口端和出口端并被磁体包围的孔（2）。 提供样品定位装置（14）用于插入到孔（2）的入口端中，以将样品定位在耦合到微波源的照射位置。 溶解基座（20）位于孔（2）的出口端，样品定位装置（14）在样品的DNP之后移动到所述孔的出口端; 并且溶剂供应系统在压力下将加热的溶剂输送到溶解基座（20）处的样品，而不将其通过孔（2），并将溶解的极化样品输送到NMR装置。 溶剂供应系统的管道延伸到溶解位置，而不会通过样品定位装置插入的低温恒温器孔的那部分。