公开(公告)号：WO2014166883A1

公开(公告)日：2014-10-16

申请号：PCT/EP2014/056958

申请日：2014-04-07

Applicant: UNIVERSITAET ULM

Inventor： JELEZKO, Fedor ,  CAI, Jianming ,  PLENIO, Martin ,  RETZKER, Alex ,  NAYDENOV, Boris ,  SCHWARZ, Ilai

IPC: G01R33/62 ,  B82Y10/00 ,  G06N99/00 ,  G01N24/12 ,  G01R33/28 ,  G01R33/56

CPC classification number: G01R33/282 ,  B82Y10/00 ,  G01N24/006 ,  G01N24/12 ,  G01R33/5601 ,  G01R33/62 ,  G06N99/002

Abstract: The invention concerns a method for the hyperpolarisation of 13 C nuclear spin in a diamond, comprising an optical pumping step, in which colour centre electron spins in the diamond are optically pumped. The method further comprises a transfer step in which the polarisation of a long-lived state of the colour centre electron spins is transferred to 13 C nuclear spins in the diamond via a long-range interaction.

Abstract translation: 本发明涉及一种用于金刚石中13C核自旋的超极化的方法，包括光泵浦步骤，其中金刚石中的色心电子旋转被光泵浦。 该方法还包括转移步骤，其中彩色中心电子自旋的长寿命状态的极化通过长距离相互作用转移到金刚石中的13C核自旋。

公开(公告)号：WO2013153101A1

公开(公告)日：2013-10-17

申请号：PCT/EP2013/057467

申请日：2013-04-10

Applicant: BRUKER BIOSPIN AG ,  ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

Inventor： JANNIN, Sami ,  GIANOTTI, Antonio Giuseppe ,  LOHMAN, Joost ,  ENGELKE, Frank ,  MELZI, Roberto ,  BORNET, Aurélien ,  BODENHAUSEN, Geoffrey

IPC: G01R33/28 ,  G01R33/62

CPC classification number: G01R33/282 ,  G01R33/4608 ,  G01R33/5605 ,  G01R33/62

Abstract: A method for producing hyperpolarized sample material for use in magnetic resonance investigations, with a) preparing a target material, containing high γ nuclei with a short T1, - a polarizing agent with a broad EPR line, and low γ nuclei with a long T1, b) irradiating the polarizing agent in the target material with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B 0 ≥ 4.0 T, thus polarizing the high γ nuclei by DNP, c) transferring the polarization from the high γ nuclei to the low γ nuclei by Cross Polarization, d) preparing a dissolved sample material containing the hyperpolarized low y nuclei from the target material. With the inventive method, nuclei with a long longitudinal relaxation time T1 can be quickly hyperpolarized to a high polarization level.

Abstract translation: 一种生产用于磁共振研究的超极化样品材料的方法，其中a）制备包含具有短T1的高γ核的目标材料，具有宽EPR线的偏振剂和具有长T1的低γ核， b）用微波辐射照射目标材料中的偏振剂，其中目标材料处于低温并暴露于静态磁场B0> = 4.0T，从而通过DNP使高γ核偏振，c）转移极化 通过交叉极化从高γ核到低γ核，d）从目标材料制备含有超极化低Y核的溶解样品材料。 利用本发明的方法，具有长纵向弛豫时间T1的核可以快速超极化到高极化水平。

公开(公告)号：WO2013000964A1

公开(公告)日：2013-01-03

申请号：PCT/EP2012/062492

申请日：2012-06-27

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  ANNINO, Giuseppe ,  MACOR, Alessandro ,  DE RIJK, Emile ,  ALBERTI, Stefano

Inventor： ANNINO, Giuseppe ,  MACOR, Alessandro ,  DE RIJK, Emile ,  ALBERTI, Stefano

IPC: G01R33/62 ,  G01R33/345

CPC classification number: G01R33/282 ,  G01R33/20 ,  G01R33/302 ,  G01R33/3456 ,  G01R33/62

Abstract: A hyperpolarization and multiple irradiation probe head, suitable for use in connection with magnetic resonance techniques (DNP-NMR, photo-DNP-NMR, ENDOR-EPR, MRI, DNP-MRI), comprising a RF transducer for generating and detecting a RF signal, wherein said RF transducer has a conducting element (2) allowing, together with at least one fully or partially connected grid polarizer made of conducting grid elements (1) which are reciprocally spaced so as the grid is at least partially transparent to a given microwave beam (3), controlled RF current paths and a substantially uniform RF magnetic field inside the RF transducer, wherein the grid polarizer (1) and the conducting element (2) forming the RF transducer are shaped and oriented to conform to said microwave beam phase fronts, said grid polarizer and said conducting element surrounding a sample (8), which is apt to be irradiated also by said microwaves (3); the probe head being also suited for a simultaneous irradiation of the sample with THz, FIR,IR, visible, and UV electromagnetic radiation.

Abstract translation: 适用于磁共振技术（DNP-NMR，光DNP-NMR，ENDOR-EPR，MRI，DNP-MRI）的超极化和多重照射探头，包括用于产生和检测RF信号的RF换能器 ，其中所述RF换能器具有导电元件（2），所述导电元件（2）与至少一个完全或部分连接的由导电栅极元件（1）制成的栅极偏振器一起允许，所述栅极偏振器互为间隔开，使得栅格对于给定微波至少部分透明 射束（3），受控RF电流路径和射频换能器内的基本均匀的RF磁场，其中形成RF换能器的栅极偏振器（1）和导电元件（2）成形并定向成符合所述微波束相位 所述栅极偏振器和围绕样品（8）的所述导电元件，其也易于被所述微波（3）照射; 探头也适用于用THz，FIR，IR，可见和UV电磁辐射同时照射样品。

公开(公告)号：WO2013000508A1

公开(公告)日：2013-01-03

申请号：PCT/EP2011/060856

申请日：2011-06-28

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  ANNINO, Giuseppe ,  MACOR, Alessandro ,  DE RIJK, Emile ,  ALBERTI, Stefano

Inventor： ANNINO, Giuseppe ,  MACOR, Alessandro ,  DE RIJK, Emile ,  ALBERTI, Stefano

IPC: G01R33/62 ,  G01R33/345

CPC classification number: G01R33/282 ,  G01R33/20 ,  G01R33/302 ,  G01R33/3456 ,  G01R33/62

Abstract: A hyperpolarization and multiple irradiation probe head, suitable for use in connection with magnetic resonance techniques (DNP-NMR, photo-DNP-NMR, ENDOR-EPR, MRI, DNP-MRI), is apt to be irradiated by microwaves (3) together with a sample (8) and comprises a RF transducer for generating and detecting a RF signal, wherein said RF transducer has at least one grid made of grid elements (1) which are mutually spaced so as the grid is at least partially transparent to one polarization of said microwaves (3); the probe head being also suited for a simultaneous irradiation of the sample with THz, FIR, IR, visible, and UV electromagnetic radiation.

Abstract translation: 适用于磁共振技术（DNP-NMR，光DNP-NMR，ENDOR-EPR，MRI，DNP-MRI）的超极化和多重照射探针头易于被微波（3）照射 具有样品（8）并且包括用于产生和检测RF信号的RF换能器，其中所述RF换能器具有由网格元件（1）形成的至少一个网格，所述网格彼此间隔开，使得网格对于至少部分地透明到一个 所述微波（3）的极化; 探头也适用于用THz，FIR，IR，可见和UV电磁辐射同时照射样品。

公开(公告)号：WO2011160853A8

公开(公告)日：2012-03-01

申请号：PCT/EP2011003125

申请日：2011-06-24

Applicant: UNIV JW GOETHE FRANKFURT MAIN ,  KRUMMENACKER JAN ,  PRISNER THOMAS ,  DENYSENKOV VASYL ,  SCHREIBER LAURA ,  MUENNEMANN KERSTIN

Inventor： KRUMMENACKER JAN ,  PRISNER THOMAS ,  DENYSENKOV VASYL ,  SCHREIBER LAURA ,  MUENNEMANN KERSTIN

IPC: G01R33/28 ,  G01R33/62

CPC classification number: A61B5/055 ,  G01N24/12 ,  G01R33/282 ,  G01R33/5601 ,  G01R33/62

Abstract: The invention relates to a device and method for providing a hyperpolarised liquid contrast agent for use in an MRI apparatus, in particular for administering to a living being (14) in an MRI apparatus, comprising the following steps: conducting the liquid contrast agent through a pipe (34) that extends along a longitudinal axis of an MW resonator (16) that is arranged in the magnetic field of the MRI apparatus, coupling a microwave having a frequency of at least 40 GHz into the MW resonator (16), said microwave being suitable for polarising, by means of DNP, the liquid contrast agent as it flows through the pipe (34) in the MW resonator (16), wherein the contrast agent is polarised at least in phases in a continuous through-flow in the MW resonator (16) and is administered directly, wherein an MW mode is formed in the MW resonator, which along at least the majority of the longitudinal axis of the resonator has a bulge in the magnetic field strength and a node in the electrical field strength, and wherein the power of the introduced microwave and the coupling of the microwave into the resonator (16) are matched such that an amplitude of the MW magnetic field strength (formula I) is produced in the region of at least one section of the power; wherein T1,e is the relaxation time of the DNP active electrons.

Abstract translation: 示出的是一个装置，并提供使用的超极化液体造影剂在MRI装置，特别是用于施用于在MRI装置中的对象（14），其包括以下步骤的方法：（34使液体造影剂通过导管 ），其（沿着谐振器MW 16），其设置在MRI装置的磁场，耦合微波具有至少40千兆赫的MW谐振器（16的频率），其适合的纵向轴线， 以极化所述液体造影剂流动，同时通过在MW-谐振器（16）由DNP，其中所述造影剂是至少在相极化，在MW谐振器（16）的连续流，并直接施用的装置的线（34），其中MW 沿着至少在谐振器的纵向轴线在Magnetfel腹的主要部分形成的谐振器模式MW dstärke并且在电场强度的节点，并且其中，所述引入的微波的功率和微波的谐振器（16）的耦合匹配，使得在雷的至少一部分的区域中的MW-磁场强度振幅油桐（制剂 我）产生的; 其中T1中，e是DNP-活性的电子的松弛时间。

公开(公告)号：WO2011101765A1

公开(公告)日：2011-08-25

申请号：PCT/IB2011/050480

申请日：2011-02-04

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  VAN DEN BRINK, Johan Samuel

Inventor： VAN DEN BRINK, Johan Samuel

IPC: G01R33/28

CPC classification number: G01R33/281 ,  G01R33/282 ,  G01R33/5601

Abstract: A dispenser is provided for producing a nuclear hyperpolarised contrast agent. The dispenser comprises a chamber to receive a compound. A photonic hyperpolarisation system generates an OAM -photonic beam endowed with orbital angular momentum and is arranged to direct the OAM -photonic beam into the chamber so as to generate nuclear hyperpolarisation in the compound. The chamber has an output over which the hyperpolarised compound can be issued. Since the hyperpolarisation is generated ex-vivo, the penetration depth of the OAM-photonic beam in biological tissue is irrelevant for the present invention.

Abstract translation: 提供分配器用于生产核超极化造影剂。 分配器包括容纳化合物的室。 光子超极化系统产生具有轨道角动量的OAM-光子束，并被布置成将OAM-光子束引导到室中，以在化合物中产生核超极化。 该室具有可以发出超极化化合物的输出。 由于超极化是离体产生的，所以OAM光子束在生物组织中的穿透深度与本发明无关。

公开(公告)号：WO2011080697A2

公开(公告)日：2011-07-07

申请号：PCT/IB2010/056092

申请日：2010-12-28

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH ,  LEUSSLER, Christoph ,  WIRTZ, Daniel ,  BOERNERT, Peter ,  KEUPP, Jochen ,  EGGERS, Holger ,  DAVID, Bernd ,  OVERWEG, Johannes, Adrianus ,  ECKART, Rainer

Inventor： LEUSSLER, Christoph ,  WIRTZ, Daniel ,  BOERNERT, Peter ,  KEUPP, Jochen ,  EGGERS, Holger ,  DAVID, Bernd ,  OVERWEG, Johannes, Adrianus ,  ECKART, Rainer

IPC: G01R33/28

CPC classification number: G01R33/62 ,  G01R33/282 ,  G01R33/5601 ,  G01R33/5605 ,  G01R33/5608 ,  G01R33/56366 ,  G01R33/56383

Abstract: The invention relates to a dynamic nuclear polarization apparatus (116) for continuous provision of hyperpolarized samples (114) comprising dynamically nuclear polarized nuclear spins, the apparatus (116) comprising a polarization region (106) for polarization of said nuclear spins resulting in said hyperpolarized samples, wherein the apparatus (116) further comprises: a cryostat (102) for cooling the samples (114) in the polarization region (106), a magnet (100) for providing a magnetic field to the cooled samples in the polarization region (106), a radiation source (112) for concurrently to the magnetic field provision providing a nuclear polarizing radiation to the polarization region (106) for receiving the hyperpolarized samples, a sample transport system (104) for continuously receiving unpolarized samples (114), transporting the unpolarized samples to the polarization region (106) for nuclear spin polarization and providing the resulting hyperpolarized samples (114).

Abstract translation: 本发明涉及用于连续提供包含动态核极化核自旋的超极化样本（114）的动态核极化装置（116），所述装置（116）包括用于所述核自旋的极化的偏振区域（106），导致所述超极化 样品，其中所述设备（116）还包括：用于冷却所述偏振区域（106）中的样品（114）的低温恒温器（102），用于向所述偏振区域中的所述冷却样品提供磁场的磁体（100） 106），用于与磁场提供同时提供用于接收超极化样本的偏振区域（106）的核偏振辐射的辐射源（112），用于连续接收非偏振样本（114）的样本传输系统（104） 将非偏振样品运送到用于核自旋极化的偏振区域（106），并提供所得到的超极化样品（114）。

公开(公告)号：WO2010112137A8

公开(公告)日：2010-12-02

申请号：PCT/EP2010001651

申请日：2010-03-16

Applicant: UNIV JW GOETHE FRANKFURT MAIN ,  PRISNER THOMAS ,  DENYSENKOV VASYL

Inventor： PRISNER THOMAS ,  DENYSENKOV VASYL

IPC: G01N24/12 ,  G01R33/345 ,  G01R33/62

CPC classification number: G01N24/12 ,  G01R33/282 ,  G01R33/345 ,  G01R33/4808 ,  G01R33/62

Abstract: The invention discloses a dual-resonance structure (10) for DNP-NMR and/or ENDOR experiments. The dual-resonance structure (10) comprises a microwave resonator (13) for generating electromagnetic fields which are suited for EPR, and an HF resonator (12) for generating electromagnetic fields which are suited for NMR. The HF resonator (12) comprises a plurality of electrically conductive strips (14) which are arranged beside one another and are connected electrically such that an HF current can be generated in the plurality of strips (14) in such a way that the HF currents in the individual strips (14) flow simultaneously in the same direction. At the same time, a section of the HF resonator (12) forms part of the microwave resonator (30).

Abstract translation: 示出了用于DNP-NMR和/或ENDOR实验双谐振结构（10）。 双共振结构（10）包括用于产生电磁场适于EPR和用于产生电磁场适于NMR的RF谐振器（12），一个微波谐振器（30）。 HF谐振器（12）包括多个相邻的导电条（14），其被电连接，使得在所述多个条带（14）的高频电流是这样产生的，在所述RF电流 各个条带（14）同时流在相同的方向。 HF谐振器（12）的一部分同时形成微波谐振器（30）的一部分。

公开(公告)号：WO2010014893A3

公开(公告)日：2010-06-17

申请号：PCT/US2009052393

申请日：2009-07-31

Applicant: UNIV DUKE ,  WARREN WARREN S

Inventor： WARREN WARREN S

IPC: G01R33/28

CPC classification number: A61K49/08 ,  A61K49/18 ,  A61K49/1812 ,  C07C49/12 ,  G01R33/282 ,  G01R33/5601 ,  G01R33/5605

Abstract: The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then be recovered into an observable transition. Coupled with hyperpolarization techniques, this permits the preparation of a wide range of contrast agent molecules for use in magnetic resonance imaging (MRI) techniques that have long effective relaxation time.

Abstract translation: 目前公开的主题表明，具有零磁共振信号但具有极长寿命的自旋状态可以用于存储磁化，然后可以将其恢复到可观察的转变中。 结合超极化技术，这允许制备用于具有长效有效弛豫时间的磁共振成像（MRI）技术的大范围造影剂分子。

公开(公告)号：WO2010061191A1

公开(公告)日：2010-06-03

申请号：PCT/GB2009/002763

申请日：2009-11-26

Applicant: OXFORD INSTRUMENTS MOLECULAR BIOTOOLS LIMITED ,  LOHMAN, Joost, A., B. ,  ENGLEFIELD, Mark, P.

Inventor： LOHMAN, Joost, A., B. ,  ENGLEFIELD, Mark, P.

IPC: G01R33/30 ,  G01R33/62

CPC classification number: G01R33/62 ,  G01R33/282 ,  G01R33/305 ,  G01R33/307 ,  G01R33/3815

Abstract: DNP apparatus comprises: a cryostat (1) within which is located a superconducting magnet (3) and defining a bore (2) having opposite inlet and outlet ends and surrounded by the magnet. A sample positioning device (14) is provided for insertion into the inlet end of the bore (2) to locate a sample at an irradiation position coupled to a microwave source. A dissolution dock (20) is located at the outlet end of the bore (2) to which the sample positioning device (14) is moved following DNP of a sample; and a solvent supply system conveys heated solvent under pressure, without passing through the bore (2), to a sample at the dissolution dock (20), and conveys the dissolved, polarised sample to NMR apparatus. The conduits of the solvent supply system extend to the dissolution position without passing through that part of the cryostat bore through which the sample positioning device is inserted.

Abstract translation: DNP设备包括：低温恒温器（1），其中位于超导磁体（3）中并且限定具有相对的入口端和出口端并被磁体包围的孔（2）。 提供样品定位装置（14）用于插入到孔（2）的入口端中，以将样品定位在耦合到微波源的照射位置。 溶解基座（20）位于孔（2）的出口端，样品定位装置（14）在样品的DNP之后移动到所述孔的出口端; 并且溶剂供应系统在压力下将加热的溶剂输送到溶解基座（20）处的样品，而不将其通过孔（2），并将溶解的极化样品输送到NMR装置。 溶剂供应系统的管道延伸到溶解位置，而不会通过样品定位装置插入的低温恒温器孔的那部分。