公开(公告)号：WO2008055704A1

公开(公告)日：2008-05-15

申请号：PCT/EP2007/009770

申请日：2007-11-12

Applicant: DSM IP ASSETS B.V. ,  GERBER, Gustav ,  LUETTIN, Andreas ,  STRITT, Claude

Inventor： GERBER, Gustav ,  LUETTIN, Andreas ,  STRITT, Claude

IPC: C07C45/54 ,  C07C49/203 ,  C07C403/16

CPC classification number: C07C403/08 ,  C07C403/16 ,  C07C403/24 ,  C07C2601/16

Abstract: The present invention relates to a process for the preparation of β-ionones and/or α-ionones of the formulae (II) and (III) by acid catalyzed ring-closing of ψ-ionones of the formula (I) wherein R 1 to R 7 are independently selected from hydrogen and C 1 -C 4 -alkyl, R 8 is selected from hydrogen and C 1 -C 4 -alkyl and the hydroxyl group, R 9 and R 10 are independently selected from hydrogen and C 1 -C 4 -alkyl or R 9 and R 10 form together the oxygen of a carbonyl group, whereby if R 9 and R 10 form together the oxygen of a carbonyl group no α-isomer is formed comprising: a) reacting a ψ-ionone according to formula (I) in presence of a concentrated Brønsted-acid having a pKs

Abstract translation: 本发明涉及通过酸式催化闭合式（I）的α-芴酮制备式（II）和（III）的β-紫罗酮和/或α-紫罗兰酮的方法，其中R < R 1至R 7独立地选自氢和C 1 -C 4 - 亚烷基，R 8， SO 2选自氢和C 1 -C 4 - 烷基，羟基R 9和R 10选自氢和C 1 -C 4 - / SUP>独立地选自氢和C 1 -C 4 - 烷基或R 9和R 10 - 形成羰基的氧，由此如果R 9和R 10一起形成羰基的氧，则不形成α-异构体，其包括：a）使 在具有pKs <3的浓缩的布朗斯台德酸存在下，根据式（I）的α-芴酮和与浓酸基本上不混溶的有机溶剂和所述酸的稀释水溶液; b）通过加入水来水解步骤a）中获得的反应产物; 和相分离成包含式（II）和（III）的β-紫罗兰酮和/或α-紫罗酮酮的有机相，并进入水性稀酸相中; 其中在水解步骤b）中以在所述水性稀酸相中达到酸浓度为45至65重量％的量加入水，其也可以容易地与维生素A的制备方法 衍生物，胡萝卜素或类胡萝卜素。