公开(公告)号：WO2011069118A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058975

申请日：2010-12-03

Applicant: AQUINOX PHARMACEUTICALS INC. ,  MACKENZIE, Lloyd ,  MACRURY, Tom ,  HARWIG, Curtis ,  KHLEBNIKOV, Vladimir ,  SHAN, Rudong ,  PLACE, Sam ,  BIRD, Paul ,  PETTIGREW, Jeremy ,  BHATTI, Noor, Aini

Inventor： MACKENZIE, Lloyd ,  MACRURY, Tom ,  HARWIG, Curtis ,  KHLEBNIKOV, Vladimir ,  SHAN, Rudong ,  PLACE, Sam ,  BIRD, Paul ,  PETTIGREW, Jeremy ,  BHATTI, Noor, Aini

IPC: C07D311/78 ,  C07D335/04 ,  A61K31/352 ,  A61K31/382 ,  A61P35/00

CPC classification number: C07D335/04 ,  C07D311/78 ,  C07D409/06

Abstract: Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Such compounds have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluent are also disclosed, as are methods of SHIP1 modulation by administration of such compounds to an animal in need thereof.

Abstract translation: 结构（I）的化合物：包括立体异构体及其药学上可接受的盐，其中X，R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义。 这些化合物具有作为SHIP1调节剂的活性，因此可用于治疗将受益于SHIP1调节的各种疾病，病症或病症中的任何一种。 还公开了包含结构（I）化合物与药学上可接受的载体或稀释剂组合的组合物，以及通过将这些化合物施用于有需要的动物的SHIP1调节方法。