公开(公告)号：WO2009109996A3

公开(公告)日：2009-09-11

申请号：PCT/IN2009/000119

申请日：2009-02-24

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH ,  KARMALI, Priya, Prakash ,  PRAMANIK, Dipankar ,  MAJETI, Bharat, Kumar ,  CHAUDHURI, Arabinda ,  SISTLA, Ramakrishna

Inventor： KARMALI, Priya, Prakash ,  PRAMANIK, Dipankar ,  MAJETI, Bharat, Kumar ,  CHAUDHURI, Arabinda ,  SISTLA, Ramakrishna

IPC: C07C235/40 ,  A61K31/16 ,  A61K48/00

Abstract: The present invention provides a novel series of glycomimicking cationic amphiphiles containing quinic acid head-groups and methods for preparing the said cationic amphiphiles. The invention provides novel compositions containing the said amphiphiles with remarkable gene transfer properties. Furthermore, the present invention provides methods for producing immune response in mice using the above-mentioned formulations containing the said cationic amphiphiles and genetic materials encoding immunogenic antigens. The area of medical science that is likely to benefit most from the present invention is genetic immunization.

公开(公告)号：WO2009109996A2

公开(公告)日：2009-09-11

申请号：PCT/IN2009000119

申请日：2009-02-24

Applicant: COUNCIL SCIENT IND RES ,  KARMALI PRIYA PRAKASH ,  PRAMANIK DIPANKAR ,  MAJETI BHARAT KUMAR ,  CHAUDHURI ARABINDA ,  SISTLA RAMAKRISHNA

Inventor： KARMALI PRIYA PRAKASH ,  PRAMANIK DIPANKAR ,  MAJETI BHARAT KUMAR ,  CHAUDHURI ARABINDA ,  SISTLA RAMAKRISHNA

IPC: C07C235/40 ,  A61K31/16 ,  A61K48/00

CPC classification number: A61K48/0008 ,  A61K2039/53 ,  C07C235/40 ,  C12N15/88

Abstract: The present invention provides a novel series of glycomimicking cationic amphiphiles containing quinic acid head-groups and methods for preparing the said cationic amphiphiles. The invention provides novel compositions containing the said amphiphiles with remarkable gene transfer properties. Furthermore, the present invention provides methods for producing immune response in mice using the above-mentioned formulations containing the said cationic amphiphiles and genetic materials encoding immunogenic antigens. The area of medical science that is likely to benefit most from the present invention is genetic immunization.

Abstract translation: 本发明提供了含有奎尼酸头基的新型一系列含有羟基乙二醇的阳离子两亲物和制备所述阳离子两亲物的方法。 本发明提供含有具有显着基因转移性质的所述两亲物的新型组合物。 此外，本发明提供使用上述含有所述阳离子两亲物和编码免疫原性抗原的遗传物质的制剂在小鼠中产生免疫应答的方法。 可能受益于本发明的医学领域是遗传免疫。

公开(公告)号：WO2007116276A3

公开(公告)日：2007-12-21

申请号：PCT/IB2007000826

申请日：2007-03-30

Applicant: COUNCIL SCIENT IND RES ,  MAJETI BHARAT KUMAR ,  KARMALI PRIYA PRAKASH ,  DIPANKAR PRAMANIK ,  CHAUDHURI ARABINDA

Inventor： MAJETI BHARAT KUMAR ,  KARMALI PRIYA PRAKASH ,  DIPANKAR PRAMANIK ,  CHAUDHURI ARABINDA

IPC: A61K48/00 ,  A61K38/07 ,  C07K5/10

CPC classification number: C07K5/1019 ,  A61K38/00 ,  A61K48/00 ,  A61K48/0008

Abstract: The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high L27 (transformed Sl 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since L27 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).

Abstract translation: 本发明提供具有整联蛋白结合RGD功能的新一系列阳离子脂肽的合成。 本发明还提供了这些新型RGD-脂肽的高L27（转化的S180，小鼠肉瘤细胞）细胞嗜性基因转移特性。 由于L27细胞表面含有过度表达的整联蛋白，所以目前类型的具有整合素结合RGD配体的脂肽很可能会发现将抗癌基因/药物靶向肿瘤血管系统内皮细胞（拥有超表达的整联蛋白）的未来应用。

公开(公告)号：WO2007116276A2

公开(公告)日：2007-10-18

申请号：PCT/IB2007/000826

申请日：2007-03-30

Applicant: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH ,  MAJETI, Bharat, Kumar ,  KARMALI, Priya, Prakash ,  DIPANKAR, Pramanik ,  CHAUDHURI, Arabinda

Inventor： MAJETI, Bharat, Kumar ,  KARMALI, Priya, Prakash ,  DIPANKAR, Pramanik ,  CHAUDHURI, Arabinda

IPC: A61K48/00 ,  C07K5/10 ,  A61K38/07

CPC classification number: C07K5/1019 ,  A61K38/00 ,  A61K48/00 ,  A61K48/0008

Abstract: The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides phenomenally high L27 (transformed Sl 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since L27 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).

Abstract translation: 本发明提供具有整联蛋白结合RGD功能的新一系列阳离子脂肽的合成。 本发明还提供了这些新型RGD-脂肽的非常高的L27（转化的S180，小鼠肉瘤细胞）细胞嗜性基因转移特性。 由于L27细胞表面含有过度表达的整联蛋白，所以目前类型的具有整合素结合RGD配体的脂肽很可能会发现将抗癌基因/药物靶向肿瘤血管系统内皮细胞（拥有超表达的整联蛋白）的未来应用。