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公开(公告)号：WO2019014100A1
公开(公告)日：2019-01-17
申请号：PCT/US2018/041230
申请日：2018-07-09
Applicant: CELGENE CORPORATION , ALEXANDER, Matthew, D. , ARTMAN, Gerald, D., III , BRAY, Gordon, L. , CARMICHAEL, James , CARRANCIO, Soraya , CATHERS, Brian E. , CORREA, Matthew, D. , HANSEN, Joshua , HAVENS, Courtney, G. , KERCHER, Timothy, S. , LOPEZ-GIRONA, Antonia , LU, Xiaoling , MAN, Hon-Wah , NAGY, Mark, A. , NARLA, Rama, K. , PICCOTTI, Joseph, R. , PIERCE, Daniel, W. , TAVARES-GRECO, Paula, A. , WHITEFIELD, Brandon, W. , WONG, Lilly, L. , ZOU, Nanfei
Inventor： ALEXANDER, Matthew, D. , ARTMAN, Gerald, D., III , BRAY, Gordon, L. , CARMICHAEL, James , CARRANCIO, Soraya , CATHERS, Brian E. , CORREA, Matthew, D. , HANSEN, Joshua , HAVENS, Courtney, G. , KERCHER, Timothy, S. , LOPEZ-GIRONA, Antonia , LU, Xiaoling , MAN, Hon-Wah , NAGY, Mark, A. , NARLA, Rama, K. , PICCOTTI, Joseph, R. , PIERCE, Daniel, W. , TAVARES-GRECO, Paula, A. , WHITEFIELD, Brandon, W. , WONG, Lilly, L. , ZOU, Nanfei
IPC: A61K31/496 , C07D241/02 , A61K38/05 , A61K31/573 , A61P35/00
Abstract: Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.
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2.发明申请SOLID FORMS OF 3-(5-AMINO-2-METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES 审中-公开3-（5-氨基-2-甲基-4-氧代-4H-喹唑啉-3-基） - 哌啶-2,6-二酮的固体形式及其药物组合物和用途
公开(公告)号：WO2012125438A8
公开(公告)日：2013-11-21
申请号：PCT/US2012028419
申请日：2012-03-09
Applicant: CELGENE CORP , MULLER GEORGE W , MAN HON-WAH , COHEN BENJAMIN M , LI YING , XU JEAN , LEONG WILLIAM W
Inventor： MULLER GEORGE W , MAN HON-WAH , COHEN BENJAMIN M , LI YING , XU JEAN , LEONG WILLIAM W
IPC: C07D401/04 , A61K31/517 , A61P35/00
CPC classification number: C07D401/04 , A61P35/00
Abstract: Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)- piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed
Abstract translation: 包含3-（5-氨基-2-甲基-4-氧代-4H-喹唑啉-3-基） - 哌啶-2,6-二酮的固体形式，包含固体形式的组合物，制备固体形式的方法和方法 他们的用途被披露
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公开(公告)号：WO2012097116A2
公开(公告)日：2012-07-19
申请号：PCT/US2012021016
申请日：2012-01-12
Applicant: CELGENE CORP , MAN HON-WAH , CAMERON LOUISE MICHELLE , FRANK ANTHONY JOSEPH
Inventor： MAN HON-WAH , CAMERON LOUISE MICHELLE , FRANK ANTHONY JOSEPH
IPC: A61K31/4035
CPC classification number: A61K31/4035 , A61K45/06 , C07D209/46 , C07D209/48 , C07D209/49 , C07D209/66
Abstract: Provided herein are isoindole derivatives, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.
Abstract translation: 本文提供了异吲哚衍生物，其富含同位素如氘。 还提供了包含富含同位素的化合物的药物组合物，以及使用这些化合物的方法。
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4.发明申请ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME 审中-公开ARYLMETHOXY ISOINDOLINE衍生物及其组合物及其使用方法
公开(公告)号：WO2011100380A1
公开(公告)日：2011-08-18
申请号：PCT/US2011/024269
申请日：2011-02-10
Applicant: CELGENE CORPORATION , MAN, Hon-Wah , MULLER, George, W. , RUCHELMAN, Alexander , KHALIL, Ehab, M. , CHEN, Roger, Shen-Chu , ZHANG, Weihong
Inventor： MAN, Hon-Wah , MULLER, George, W. , RUCHELMAN, Alexander , KHALIL, Ehab, M. , CHEN, Roger, Shen-Chu , ZHANG, Weihong
IPC: C07D401/04 , C07D401/14 , C07D407/12 , C07D413/14 , C07D417/14 , C07D487/04 , C07D493/04 , C07D495/04 , C07D491/107 , C07D407/14 , C07D409/14 , A61P35/00 , A61K31/4412
CPC classification number: C07D401/12 , C07D401/04 , C07D401/14 , C07D407/12 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/107 , C07D493/04 , C07D495/04
Abstract: Provided are 4'-arylmethoxy isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed. The compounds are derivatives of hydroxy thalidomide active against cancer.
Abstract translation: 提供4'-芳基甲氧基异二氢吲哚化合物及其药学上可接受的盐，溶剂合物，包合物，立体异构体和前药。 公开了这些化合物的使用方法和药物组合物。 该化合物是对癌症有活性的羟基沙利度胺的衍生物。
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公开(公告)号：WO2010093605A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/023581
申请日：2010-02-09
Applicant: CELGENE CORPORATION , MULLER, George, W. , MAN, Hon-Wah
Inventor： MULLER, George, W. , MAN, Hon-Wah
IPC: C07D401/04 , A61K31/454 , A61P35/00
CPC classification number: C07D401/04 , C07B2200/05
Abstract: Provided herein are thalidomide, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.
Abstract translation: 本文提供沙利度胺，其富含同位素如氘。 还提供了包含富含同位素的化合物的药物组合物，以及使用这些化合物的方法。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2006025991A3
公开(公告)日：2006-08-24
申请号：PCT/US2005026680
申请日：2005-07-27
Applicant: CELGENE CORP , MULLER GEORGE W , MAN HON-WAH
Inventor： MULLER GEORGE W , MAN HON-WAH
IPC: C07D209/46 , A61K31/4035 , A61P11/00 , A61P29/00 , A61P35/00 , C07D209/48
CPC classification number: C07D209/48 , C07D209/46 , C07D209/66 , C07D405/12
Abstract: The invention encompasses isoindoline compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel disease and myelodysplastic syndrome.
Abstract translation: 本发明包括异吲哚啉化合物，包含它们的药物组合物，以及它们用于治疗，预防或控制各种疾病和病症的方法。 实例包括但不限于癌症，炎症性肠病和骨髓增生异常综合征。
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7.发明申请
公开(公告)号：WO2004080423A3
公开(公告)日：2004-11-04
申请号：PCT/US2004007743
申请日：2004-03-12
Applicant: CELGENE CORP , MAN HON-WAH , MULLER GEORGE W , ZHANG WEIHONG
Inventor： MAN HON-WAH , MULLER GEORGE W , ZHANG WEIHONG
IPC: A61K31/4035 , A61K31/425 , A61K31/4706 , A61P35/00 , C07D209/46 , C07D209/48 , C07D217/22 , C07D275/06 , C07D401/06
CPC classification number: C07D401/06 , C07D209/46
Abstract: The invention encompasses 7-amido-isoindolyl compounds of formula (I) and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel disease and myelodysplastic syndrome.
Abstract translation: 本发明包括式（I）的7-氨基 - 异吲哚基化合物和在哺乳动物中使用这些化合物和组合物用于治疗，预防或治疗各种疾病和病症的方法。 实例包括但不限于癌症，炎症性肠病和骨髓增生异常综合征。
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公开(公告)号：WO2004078144A3
公开(公告)日：2004-09-16
申请号：PCT/US2004/006781
申请日：2004-03-05
Applicant: CELGENE CORPORATION , MULLER, George, W. , PAYVANDI, Faribourz , ZHANG, Ling, H. , ROBARGE, Michael, J. , CHEN, Roger , MAN, Hon-Wah
Inventor： MULLER, George, W. , PAYVANDI, Faribourz , ZHANG, Ling, H. , ROBARGE, Michael, J. , CHEN, Roger , MAN, Hon-Wah
IPC: C07C233/33
Abstract: The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.
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9.发明申请FLUOROALKOXY-SUBSTITUTED 1, 3-DIHYDRO-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES 审中-公开氟取代1,3-DIHYDRO-ISOINDOLYL化合物及其药物用途
公开(公告)号：WO2004060313A2
公开(公告)日：2004-07-22
申请号：PCT/US2003/041568
申请日：2003-12-29
Applicant: CELGENE CORPORATION , MULLER, George, W. , MAN, Hon-Wah , ZHANG, Weihong
Inventor： MULLER, George, W. , MAN, Hon-Wah , ZHANG, Weihong
IPC: A61K
CPC classification number: C07D209/48 , A61K31/4035 , A61K31/4178 , A61K31/4184 , A61K31/425 , A61K31/4709 , A61K45/06 , C07D209/46 , Y02A50/411 , A61K2300/00
Abstract: The invention encompasses novel compounds, pharmaceutically acceptable salts, hydrates solvates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof, pharmaceutical compositions of these compounds, and methods of using these compounds in mammals for treatment or prevention of diseases associated with PDE4.
Abstract translation: 本发明包括新型化合物，药学上可接受的盐，水合物溶剂化物，溶剂化物，包合物，对映异构体，非对映异构体，外消旋体或其立体异构体的混合物，这些化合物的药物组合物，以及在哺乳动物中使用这些化合物治疗或预防相关疾病的方法 与PDE4。
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10.发明申请SOLID FORMS OF 3-(5-AMINO-2METHYL-4-OXO-4H-QUINAZOLIN-3-YL)-PIPERIDINE-2,6-DIONE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES 审中-公开3-（5-氨基-2-乙基-4-氧代-4H-喹唑啉-3-基） - 哌啶-2,6-二酮的固体形式及其药物组合物和用途
公开(公告)号：WO2012125438A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/028419
申请日：2012-03-09
Applicant: CELGENE CORPORATION , MULLER, George W. , MAN, Hon-wah , COHEN, Benjamin M. , LI, Ying , XU, Jean , LEONG, William W.
Inventor： MULLER, George W. , MAN, Hon-wah , COHEN, Benjamin M. , LI, Ying , XU, Jean , LEONG, William W.
IPC: C07D401/04 , A61K31/517 , A61P35/00
CPC classification number: C07D401/04 , A61P35/00
Abstract: Solid forms comprising 3-(5-amino-2-methyl-4-oxo-4H-quinazolin-3-yl)- piperidine-2,6-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their uses are disclosed
Abstract translation: 包含3-（5-氨基-2-甲基-4-氧代-4H-喹唑啉-3-基） - 哌啶-2,6-二酮的固体形式，包含固体形式的组合物，制备固体形式的方法和方法 他们的用途被披露
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