公开(公告)号：WO2007021449A3

公开(公告)日：2007-12-06

申请号：PCT/US2006028398

申请日：2006-07-21

Applicant: WORLDWIDE MEDICAL TECHNOLOGIES ,  LAMOUREUX GARY A ,  MATONS JAMES ,  JOHNSTON WARREN ,  BOUFFARD MATTHEW ,  RICE WARREN

Inventor： LAMOUREUX GARY A ,  MATONS JAMES ,  JOHNSTON WARREN ,  BOUFFARD MATTHEW ,  RICE WARREN

IPC: A61M36/00

CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

Abstract: Therapeutic members and strands for use in brachytherapy are designed to reduce the tendency for the members and strands (and thus the radioactive sources, thermal ablation implants and/or radiopaque makers, etc. therein) to migrate and/or rotate within a patient's body. In one embodiment a member includes a radioactive source and a material that encapsulates the radioactive source. Such encapsulating material, which is preferably, but not necessarily, bioabsorbable, is likely polymeric or some other plastic material. An outer surface of the encapsulating material includes at least one protrusion, and preferably a plurality of protrusions, to reduce the tendency of the member to migrate and rotate within a patient's body after implantation. Other embodiments are also provided.

Abstract translation: 用于近距离放射治疗的治疗部件和股线被设计成减少患者身体内的成员和股线（并且因此放射源，热消融植入物和/或不透射线的制造者等）在患者体内迁移和/或旋转的趋势。 在一个实施方案中，成员包括放射源和封装放射源的材料。 这种优选但不是必须是生物可吸收的包封材料可能是聚合物或一些其它塑料材料。 封装材料的外表面包括至少一个突起，优选多个突起，以减少在植入后患者身体迁移和旋转的倾向。 还提供了其他实施例。

公开(公告)号：WO2007021449A2

公开(公告)日：2007-02-22

申请号：PCT/US2006/028398

申请日：2006-07-21

Applicant: WORLDWIDE MEDICAL TECHNOLOGIES LLC ,  LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

Inventor： LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

IPC: A61N5/00 ,  A61M36/00

CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

Abstract: Therapeutic members and strands for use in brachytherapy are designed to reduce the tendency for the members and strands (and thus the radioactive sources, thermal ablation implants and/or radiopaque makers, etc. therein) to migrate and/or rotate within a patient's body. In one embodiment a member includes a radioactive source and a material that encapsulates the radioactive source. Such encapsulating material, which is preferably, but not necessarily, bioabsorbable, is likely polymeric or some other plastic material. An outer surface of the encapsulating material includes at least one protrusion, and preferably a plurality of protrusions, to reduce the tendency of the member to migrate and rotate within a patient's body after implantation. Other embodiments are also provided.

Abstract translation: 用于近距离放射治疗的治疗成员和股线被设计用于减少成员和股（以及因此其中的放射源，热消融植入物和/或不透射线的制造者等）迁移的倾向，并且 /或在患者体内旋转。 在一个实施例中，构件包括放射源和封装放射源的材料。 这种包封材料优选但不一定是生物可吸收的，可能是聚合物或其他塑料材料。 封装材料的外表面包括至少一个突起，并且优选地具有多个突起，以减少在植入之后该构件在患者体内迁移和旋转的趋势。 还提供了其他实施例。

公开(公告)号：WO2010099126A2

公开(公告)日：2010-09-02

申请号：PCT/US2010/025113

申请日：2010-02-23

Applicant: BIOCOMPATIBLES UK LIMITED ,  LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

Inventor： LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

IPC: A61M36/04 ,  A61M36/00 ,  A61N5/00 ,  A61M36/12

CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

Abstract: A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.

Abstract translation: 用于通过针可递送到植入部位的近距离放射治疗的治疗部件包括由生物可吸收材料包封的单个放射源，所述生物可吸收材料具有外表面，该外表面包括环绕单个放射源的一个或多个肋，前缘端盖肋和 后缘端盖肋。 一个或多个肋降低了植入后患者身体内移动和旋转的倾向。 封装材料还包括由生物可吸收材料形成的第一轨道，其至少从包封材料的外表面的相对侧沿着治疗构件的纵向轴线延伸，以及由生物可吸收材料形成的第二轨道 至少从包封材料的外表面的相对侧沿着施疗件的纵向轴线，第二导轨布置成大致垂直于第一导轨布置的平面的平面。

公开(公告)号：WO2010099126A3

公开(公告)日：2011-01-20

申请号：PCT/US2010025113

申请日：2010-02-23

Applicant: BIOCOMPATIBLES UK LTD ,  LAMOUREUX GARY A ,  MATONS JAMES ,  JOHNSTON WARREN ,  BOUFFARD MATTHEW ,  RICE WARREN

Inventor： LAMOUREUX GARY A ,  MATONS JAMES ,  JOHNSTON WARREN ,  BOUFFARD MATTHEW ,  RICE WARREN

IPC: A61M36/04 ,  A61M36/00 ,  A61M36/12 ,  A61N5/00

CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

Abstract: A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.

Abstract translation: 用于通过针可递送到植入部位的近距离放射治疗的治疗部件包括由生物可吸收材料包封的单个放射源，所述生物可吸收材料具有外表面，该外表面包括环绕单个放射源的一个或多个肋，前缘端盖肋和 后缘端盖肋。 一个或多个肋降低了植入后患者身体内移动和旋转的倾向。 封装材料还包括由生物可吸收材料形成的第一轨道，其至少从包封材料的外表面的相对侧沿着治疗构件的纵向轴线延伸，以及由生物可吸收材料形成的第二轨道 至少从包封材料的外表面的相对侧沿着施疗件的纵向轴线，第二导轨布置成大致垂直于第一导轨布置的平面的平面。

公开(公告)号：WO2009097408A1

公开(公告)日：2009-08-06

申请号：PCT/US2009/032408

申请日：2009-01-29

Applicant: BIOCOMPATIBLES UK LIMITED ,  LAMOUREUX, Gary, A. ,  MATONS, James

Inventor： LAMOUREUX, Gary, A. ,  MATONS, James

IPC: A61N5/00

CPC classification number: A61N5/1001 ,  A61N2005/1019 ,  A61N2005/1023

Abstract: Provided herein are bio-absorbable strands for use in brachytherapy. In an embodiment, a plurality of discrete hollow bio-absorbable segments spaced apart from one another and encapsulated using a bio-absorbable material to form an elongated member configured to be implantable in patient tissue using a hollow needle. Each hollow bio-absorbable segment has a length, an outer periphery and an inner channel. Radioactive material is within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment. Contrast material is within at least a portion of the inner channel or coating at least a portion of the outer periphery of each hollow bio-absorbable segment.

Abstract translation: 本文提供了用于近距离放射治疗的生物吸收性线。 在一个实施方案中，多个离散的中空生物可吸收段彼此间隔开并且使用生物可吸收材料封装以形成细长构件，该细长构件构造成可以使用中空针可植入患者组织。 每个中空生物吸收段具有长度，外周和内通道。 放射性物质在内部通道的至少一部分内，或涂覆每个中空生物可吸收段的外周边的至少一部分。 对比材料在内部通道的至少一部分内，或涂覆每个中空生物可吸收段的外周边的至少一部分。