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    THERAPEUTIC MEMBER INCLUDING A RAIL TO RESIST MOVEMENT WITHIN A NEEDLE USED IN BRACHYTHERAPY AND OTHER RADIATION THERAPY
    1.
    发明申请
    THERAPEUTIC MEMBER INCLUDING A RAIL TO RESIST MOVEMENT WITHIN A NEEDLE USED IN BRACHYTHERAPY AND OTHER RADIATION THERAPY 审中-公开
    治疗性成员包括用于抵抗在BRACHYTHERAPY和其他辐射治疗中使用的针头中的运动的轨道

    公开(公告)号：WO2010099126A2

    公开(公告)日：2010-09-02

    申请号：PCT/US2010/025113

    申请日：2010-02-23

    Applicant: BIOCOMPATIBLES UK LIMITED ,  LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

    Inventor： LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

    IPC: A61M36/04 ,  A61M36/00 ,  A61N5/00 ,  A61M36/12

    CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

    Abstract: A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.

    Abstract translation: 用于通过针可递送到植入部位的近距离放射治疗的治疗部件包括由生物可吸收材料包封的单个放射源，所述生物可吸收材料具有外表面，该外表面包括环绕单个放射源的一个或多个肋，前缘端盖肋和 后缘端盖肋。 一个或多个肋降低了植入后患者身体内移动和旋转的倾向。 封装材料还包括由生物可吸收材料形成的第一轨道，其至少从包封材料的外表面的相对侧沿着治疗构件的纵向轴线延伸，以及由生物可吸收材料形成的第二轨道 至少从包封材料的外表面的相对侧沿着施疗件的纵向轴线，第二导轨布置成大致垂直于第一导轨布置的平面的平面。

    IMPLANTS FOR USE IN BRACHYTHERAPY AND OTHER RADIATION THERAPY THAT RESIST MIGRATION AND ROTATION
    4.
    发明申请
    IMPLANTS FOR USE IN BRACHYTHERAPY AND OTHER RADIATION THERAPY THAT RESIST MIGRATION AND ROTATION 审中-公开
    植入物用于短程治疗和其他放射治疗，抵制迁移和旋转

    公开(公告)号：WO2007021449A2

    公开(公告)日：2007-02-22

    申请号：PCT/US2006/028398

    申请日：2006-07-21

    Applicant: WORLDWIDE MEDICAL TECHNOLOGIES LLC ,  LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

    Inventor： LAMOUREUX, Gary, A. ,  MATONS, James ,  JOHNSTON, Warren ,  BOUFFARD, Matthew ,  RICE, Warren

    IPC: A61N5/00 ,  A61M36/00

    CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024

    Abstract: Therapeutic members and strands for use in brachytherapy are designed to reduce the tendency for the members and strands (and thus the radioactive sources, thermal ablation implants and/or radiopaque makers, etc. therein) to migrate and/or rotate within a patient's body. In one embodiment a member includes a radioactive source and a material that encapsulates the radioactive source. Such encapsulating material, which is preferably, but not necessarily, bioabsorbable, is likely polymeric or some other plastic material. An outer surface of the encapsulating material includes at least one protrusion, and preferably a plurality of protrusions, to reduce the tendency of the member to migrate and rotate within a patient's body after implantation. Other embodiments are also provided.

    Abstract translation: 用于近距离放射治疗的治疗成员和股线被设计用于减少成员和股（以及因此其中的放射源，热消融植入物和/或不透射线的制造者等）迁移的倾向，并且 /或在患者体内旋转。 在一个实施例中，构件包括放射源和封装放射源的材料。 这种包封材料优选但不一定是生物可吸收的，可能是聚合物或其他塑料材料。 封装材料的外表面包括至少一个突起，并且优选地具有多个突起，以减少在植入之后该构件在患者体内迁移和旋转的趋势。 还提供了其他实施例。

    DELIVERY SYSTEM AND PRESCRIPTION METHOD FOR INTERSTITIAL RADIATION THERAPY USING ENHANCED PARAMETRIC RELEASE STERILIZATION TECHNIQUES
    5.
    发明申请
    DELIVERY SYSTEM AND PRESCRIPTION METHOD FOR INTERSTITIAL RADIATION THERAPY USING ENHANCED PARAMETRIC RELEASE STERILIZATION TECHNIQUES 审中-公开

    公开(公告)号：WO2005051457A3

    公开(公告)日：2005-06-09

    申请号：PCT/US2004/038647

    申请日：2004-11-18

    Applicant: IDEAMATRIX, INC. ,  TERWILLIGER, Richard, A. ,  LAMOUREUX, Gary, A.

    Inventor： TERWILLIGER, Richard, A. ,  LAMOUREUX, Gary, A.

    IPC: A61L9/00

    Abstract: A process is provided for sterilizing brachytherapy devices (10) with Ethylene Oxide gas and releasing the devices (10) on a parametric release basis. Devices that can be sterilized with this process include interstitial radiation seed strand (12) implants and the needles (14) used for implantation. In order to be sterilized effectively by EtO gas, the devices (10) are constructed such that surfaces not readily infused with EtO gas are made to be gas permeable, and will not retain the gas after the sterilization process. Performance qualification of the sterilization process is performed through physical and microbiological studies, and set of established physical process parameters. Maintaining the physical process parameters in subsequent sterilization cycles will consistently yield the desired sterility assurance level without having to test the devices for sterility.

    DELIVERY SYSTEM AND PRESCRIPTION METHOD FOR INTERSTITIAL RADIATION THERAPY USING ENHANCED PARAMETRIC RELEASE STERILIZATION TECHNIQUES
    6.
    发明申请
    DELIVERY SYSTEM AND PRESCRIPTION METHOD FOR INTERSTITIAL RADIATION THERAPY USING ENHANCED PARAMETRIC RELEASE STERILIZATION TECHNIQUES 审中-公开
    使用增强参数释放灭菌技术进行间断放射治疗的输送系统和处方方法

    公开(公告)号：WO2005051457A2

    公开(公告)日：2005-06-09

    申请号：PCT/US2004038647

    申请日：2004-11-18

    Applicant: TERWILLIGER RICHARD A ,  LAMOUREUX GARY A ,  IDEAMATRIX INC

    Inventor： TERWILLIGER RICHARD A ,  LAMOUREUX GARY A

    IPC: A61L2/00 ,  A61L2/20 ,  A61L9/00 ,  A61M20060101 ,  A61M31/00 ,  A61M36/00 ,  A61N5/00 ,  A61N5/10 ,  B01J19/00 ,  A61M

    CPC classification number: A61L2/206 ,  A61N5/1027 ,  A61N2005/1011

    Abstract: A process is provided for sterilizing brachythearpy devices with Ethylene Oxide gas and releasing the devices on a parametric release basis. Devices that can be sterilized with this process include interstitial radiation seed strand implants and the needles used for implantation. In order to be sterilized effectively by EtO gas, the devices are constructed such that surfaces not readily infused with EtO gas are made to be gas permeable, and will not retain the gas after the sterilization process. Performance qualification of the sterilization process is performed through physical and microbiological studies, and set of established physical process parameters. Maintaining the physical process parameters in subsequent sterilization cycles will consistently yield the desired sterility assurance level without having to test the devices for sterility.

    Abstract translation: 提供了一种使用环氧乙烷气体灭菌近距离装置的方法，并以参数释放为基础释放装置。 可以用该方法灭菌的装置包括间质辐射种子线植入物和用于植入的针。 为了通过EtO气体有效灭菌，这些装置被构造成使得不容易注入EtO气体的表面被制成透气性，并且在灭菌过程之后不会保留气体。 灭菌过程的性能鉴定通过物理和微生物学研究以及既定的物理过程参数进行。 在随后的灭菌循环中保持物理过程参数将一直产生所需的无菌保证水平，而无需测试设备的无菌性。

    DELIVERY SYSTEM AND METHOD FOR INTERSTITIAL RADIATION THERAPY USING SEED STRANDS WITH CUSTOM END SPACING
    7.
    发明申请
    DELIVERY SYSTEM AND METHOD FOR INTERSTITIAL RADIATION THERAPY USING SEED STRANDS WITH CUSTOM END SPACING 审中-公开
    使用具有定制末端间距的种子条进行间隔辐射治疗的递送系统和方法

    公开(公告)号：WO2004101026A3

    公开(公告)日：2005-04-07

    申请号：PCT/US2004014732

    申请日：2004-05-12

    Applicant: TERWILLIGER RICHARD A ,  LAMOUREUX GARY A ,  IDEAMATRIX INC

    Inventor： TERWILLIGER RICHARD A ,  LAMOUREUX GARY A

    IPC: A61B17/34 ,  A61M20060101 ,  A61M36/12 ,  A61N5/10

    CPC classification number: A61M37/0069 ,  A61B17/3468 ,  A61B2017/3407 ,  A61B2017/3411 ,  A61N5/1027 ,  A61N2005/1012 ,  A61N2005/1023

    Abstract: A delivery system and method for interstitial radiation therapy comprising a substantially axially stiff and longitudinally flexible elongated strand made of material, which is bio-absorbable in living tissue and a plurality of radioactive seeds dispersed in a predeterrnined array within the strand. The delivery system and method further customize the strand based on a prescription. The strands can have custom end spacings, which allow the optimal placing of seeds within the treatment tissue by implanting a plurality of strands to the same depth. A plurality of these strands can be implanted at the same time by the use of a guiding device.

    Abstract translation: 一种用于间质放射治疗的递送系统和方法，包括在生物体组织中可生物吸收的基本上轴向刚性和纵向柔性的细长股线，所述细长股线由分散在股线内的预定阵列中的多个放射性种子组成。 递送系统和方法基于处方进一步定制链。 股线可以具有定制的端部间隔，其允许通过将多个股线植入同一深度来最佳地将种子放置在处理组织内。 可以通过使用引导装置同时植入多个这些股线。

    DELIVERY SYSTEM AND METHOD FOR INTERSTITIAL RADIATION THERAPY USING SEED STRANDS CONSTRUCTED WITH PREFORMED STRAND HOUSING
    8.
    发明申请
    DELIVERY SYSTEM AND METHOD FOR INTERSTITIAL RADIATION THERAPY USING SEED STRANDS CONSTRUCTED WITH PREFORMED STRAND HOUSING 审中-公开
    交付系统和方法用于采用预先设计的住房构造的种子结构进行间断辐射治疗

    公开(公告)号：WO2003039643A2

    公开(公告)日：2003-05-15

    申请号：PCT/US2002/035176

    申请日：2002-11-01

    Applicant: TERWILLIGIER, Richard, A. ,  LAMOUREUX, Gary, A.

    Inventor： TERWILLIGIER, Richard, A. ,  LAMOUREUX, Gary, A.

    IPC: A61M36/12

    CPC classification number: A61N5/1027 ,  A61N2005/1023 ,  A61N2005/1024 ,  B29C47/0023 ,  B29C47/021 ,  B29C47/028 ,  G21G4/08

    Abstract: A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and radially flexible elongated members made of material which is bioabsorbable in linving tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands is also provided. The delivery system and method further customize the member based on a prescription.

    Abstract translation: 用于间质放射治疗的递送系统和方法包括基本轴向刚性和径向柔性的细长构件，其由在线组织中生物可吸收的材料和以预定阵列分散在细长构件内的多个放射性种子制成。 放射性种子可以分散在由相同材料制成的组装的半壳内。 用于辐射种子的外壳也可以由挤压材料制成。 还提供了用于制造自动制作种子股的间质放射治疗种子股的系统。 递送系统和方法基于处方进一步定制成员。

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