公开(公告)号：WO2007120855A3

公开(公告)日：2007-10-25

申请号：PCT/US2007/009185

申请日：2007-04-16

Applicant: EBI, L.P. ,  HALANSKI, Matthew A. ,  HEIBERG, Eric ,  MCCORMICK, Steven ,  NOONAN, Kenneth

Inventor： HALANSKI, Matthew A. ,  HEIBERG, Eric ,  MCCORMICK, Steven ,  NOONAN, Kenneth

IPC: A61L15/14 ,  A61L15/56

Abstract: Safety cast compositions for the prevention of thermal injury are provided basically comprising a curable casting material, a flexible substrate coated or impregnated with the casting material and a thermochromic material. Methods for using the safety cast to prevent cast burns in patients in need of immobilizing a body member are also provided.

公开(公告)号：WO2004080321A1

公开(公告)日：2004-09-23

申请号：PCT/US2004/006709

申请日：2004-03-04

Applicant: THE RESEARCH FOUNDATION OF CUNY ,  THE NEW YORK EYE AND EAR INFIRMARY ,  ALFANO, Robert, R. ,  GAYEN, Tapan, K. ,  MCCORMICK, Steven, A. ,  ROSEN, Richard ,  KATZ, Alvin ,  SAVAGE, Howard, E.

Inventor： ALFANO, Robert, R. ,  GAYEN, Tapan, K. ,  MCCORMICK, Steven, A. ,  ROSEN, Richard ,  KATZ, Alvin ,  SAVAGE, Howard, E.

IPC: A61B18/20

CPC classification number: A61F9/00821 ,  A61F9/008 ,  A61F2009/00863 ,  A61F2009/00865 ,  A61F2009/00872

Abstract: A system and method for exposing ocular tissue to a beam of electromagnetic radiation tuned to an NIR wavelength between about 1380 nm and about 1600 nm in the water absorption band. The laser energy is absorbed by the water, which in turn, transfers the energy to collagen molecules. The helical collagen molecules partially denature and then re-nature to form a weld across the region of the tissues to be joined. In a preferred embodiment, the electromagnetic radiation originates from a laser. The lasers may be Cr 4+ doped crystals, Erbium fibers, and alloys of semiconductor laser diodes.

Abstract translation: 一种将眼组织暴露于吸水带中调谐到约1380nm至约1600nm之间的NIR波长的电磁辐射束的系统和方法。 激光能量被水吸收，这又将能量转移到胶原分子。 螺旋胶原分子部分变性，然后重新自然，以在待连接的组织的区域上形成焊缝。 在优选实施例中，电磁辐射源于激光。 激光器可以是Cr + 4+掺杂晶体，铒光纤和半导体激光二极管的合金。

公开(公告)号：WO2007120855A2

公开(公告)日：2007-10-25

申请号：PCT/US2007009185

申请日：2007-04-16

Applicant: EBI LP ,  HALANSKI MATTHEW A ,  HEIBERG ERIC ,  MCCORMICK STEVEN ,  NOONAN KENNETH

Inventor： HALANSKI MATTHEW A ,  HEIBERG ERIC ,  MCCORMICK STEVEN ,  NOONAN KENNETH

IPC: A61F5/01 ,  A61L15/00

CPC classification number: A61L15/12 ,  A61F5/01 ,  A61F13/04 ,  A61F2013/00153 ,  A61F2013/00387 ,  A61F2013/00953 ,  A61F2013/8497 ,  A61L15/07 ,  A61L15/14

Abstract: Safety cast compositions for the prevention of thermal injury are provided basically comprising a curable casting material, a flexible substrate coated or impregnated with the casting material and a thermochromic material. Methods for using the safety cast to prevent cast burns in patients in need of immobilizing a body member are also provided.

Abstract translation: 提供了用于防止热损伤的安全铸造组合物，其基本上包括可固化浇铸材料，涂覆或浸渍有铸造材料的柔性基材和热变色材料。 还提供了使用安全铸件来防止需要固定身体构件的患者中的灼伤的方法。

公开(公告)号：WO2005105992A1

公开(公告)日：2005-11-10

申请号：PCT/US2005/013515

申请日：2005-04-19

Applicant: NEW YORK EYE & EAR INFIRMARY ,  HU, Dan-Ning ,  MCCORMICK, Steven

Inventor： HU, Dan-Ning ,  MCCORMICK, Steven

IPC: C12N15/00

CPC classification number: C12N5/0655 ,  A61K35/12 ,  C12N2500/32 ,  C12N2501/115 ,  C12N2501/12 ,  C12N2501/135 ,  C12N2501/33

Abstract: The present invention provides methods and compositions for providing graft recipients with chondrocytes. Specifically, the methods and compositions of the invention provide for populations of chondrocytes that may be isolated from a patient and cultured in vitro to generate a proliferating population of chondrocytes that exhibit great proliferation capacity. The invention is based, in part, on the discovery of a culture medium having serum, insulin and various growth factors for culturing chondrocytes that exhibit increased proliferative capacity. The invention provides novel in vitro methods for culturing chondrocytes, including those isolated from the cartilage of a healthy subject, to generate a proliferating population of chondrocytes. The methods and compositions of the invention may be used for transplantation to treat patients having damaged cartilage.

Abstract translation: 本发明提供了用于向移植受体提供软骨细胞的方法和组合物。 具体地说，本发明的方法和组合物提供可以从患者中分离并在体外培养的软骨细胞群，以产生显示出巨大增殖能力的增殖性软骨细胞群。 本发明部分地基于发现具有血清，胰岛素和各种生长因子的培养基，用于培养显示出增加的增殖能力的软骨细胞。 本发明提供了用于培养软骨细胞的新颖的体外方法，包括从健康受试者的软骨分离的软骨细胞，以产生增殖的软骨细胞群体。 本发明的方法和组合物可用于移植以治疗患有软骨损伤的患者。