公开(公告)号：WO1998009603A2

公开(公告)日：1998-03-12

申请号：PCT/US1997015940

申请日：1997-09-08

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER ,  WECHTER, William, J. ,  McCRACKEN, John, D.

Inventor： LOMA LINDA UNIVERSITY MEDICAL CENTER

IPC: A61K00/00

CPC classification number: A61K31/192 ,  A61K31/35 ,  A61K31/407

Abstract: A composition including an enantiomerically stable R-NSAID or a pharmaceutically acceptable salt thereof, the composition being substantially free of the S-enantiomer of the selected R-NSAID.

Abstract translation: 包含对映异构体稳定的R-NSAID或其药学上可接受的盐的组合物，所述组合物基本上不含所选择的R-NSAID的S-对映异构体。

公开(公告)号：WO2013049809A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/058291

申请日：2012-10-01

Applicant: ABT MOLECULAR IMAGING INC. ,  NUTT, Ronald ,  PATTON, SR., David ,  SWICEGOOD, Darrell ,  MCCRACKEN, John

Inventor： NUTT, Ronald ,  PATTON, SR., David ,  SWICEGOOD, Darrell ,  MCCRACKEN, John

IPC: G21G1/10

CPC classification number: G21G1/10

Abstract: A target assembly to produce radioisotopes for the synthesis of radiopharmaceuticals. The target assembly includes a target vessel with a target chamber adapted to receive a target material. A thin cover sheet of particle-permeable material covers the target chamber. In a bombardment process, a high-energy particle beam generated by a cyclotron or particle accelerator strikes the thin cover sheet, whereby at least some of the particles from the particle beam penetrate to the target chamber so as to interact with the target material, altering the nuclear makeup of some of the atoms in the target material to produce radioisotopes.

Abstract translation: 用于生产放射性药物合成放射性同位素的目标组件。 目标组件包括具有适于接收目标材料的靶室的靶容器。 透明材料的薄覆盖层覆盖目标室。 在轰击过程中，由回旋加速器或粒子加速器产生的高能量粒子束撞击薄覆盖片，由此来自粒子束的至少一些粒子穿透到靶室，以便与目标材料相互作用，改变 目标材料中一些原子的核构象产生放射性同位素。

公开(公告)号：WO2004076116A1

公开(公告)日：2004-09-10

申请号：PCT/AU2004/000245

申请日：2004-02-26

Applicant: BRADKEN RESOURCES PTY LTD ,  MUIR, Darren ,  MCCRACKEN, John

Inventor： MUIR, Darren ,  MCCRACKEN, John

IPC: B23K5/18

CPC classification number: B23K9/044 ,  C21D1/25 ,  C21D2211/008 ,  C23C4/18 ,  C23C26/02 ,  C23C30/00 ,  Y10T428/12965 ,  Y10T428/12972

Abstract: A method of hard-facing a steel casting is described in which a hard-facing, which comprises a weld alloy matrix and a hard particulate substance, is attached to the casting by welding. In some embodiments the matrix can be of a similar composition to the casting, and in other embodiments the hard particulates can be rounded and/or substantially spherical, or of a substantially even size. A method is also described for hardening and tempering a steel casting after attaching the hard-facing to the casting by welding. After hard-facing the casting is hardened and tempered by heat treatment. In one embodiment the hard-faced casting is heat treated by heating to a temperature in excess of the austenitising temperature of the steel and then cooled by quenching in an aqueous solution, followed by tempering. In one embodiment the steel casting is tempered at a temperature in the range about 550°C to about 700°C prior to hard-facing the casting.

Abstract translation: 描述了一种硬质铸钢件的方法，其中包括焊接合金基体和硬颗粒物质的硬面通过焊接附接到铸件上。 在一些实施方案中，基质可以具有与铸件相似的组成，并且在其它实施方案中，硬颗粒可以是圆形和/或基本上球形的，或基本上均匀的尺寸。 还描述了一种用于通过焊接将硬质面附着到铸件上之后对钢铸件进行硬化和回火的方法。 硬面后，铸件通过热处理硬化和回火。 在一个实施例中，硬面铸件通过加热至超过钢的奥氏体化温度的温度进行热处理，然后通过在水溶液中淬火冷却，随后回火。 在一个实施例中，在铸造硬面之前，钢铸件在约550℃至约700℃的温度下回火。

公开(公告)号：WO9628148A3

公开(公告)日：1996-11-14

申请号：PCT/US9603495

申请日：1996-03-13

Applicant: UNIV LOMA LINDA MED ,  WECHTER WILLIAM J ,  MCCRACKEN JOHN D

Inventor： WECHTER WILLIAM J ,  MCCRACKEN JOHN D

IPC: A61K45/00 ,  A61K31/19 ,  A61K31/192 ,  A61K31/28 ,  A61K31/315 ,  A61K31/40 ,  A61P1/00 ,  A61P3/02 ,  A61P43/00

CPC classification number: A61K31/192

Abstract: A composition for use in preventing colorectal cancer and other neoplactic diseases includes an enantiomerically stable R-NSAID or a pharmaceutically acceptable salt thereof in an amount effective to elicit a chemoprotective effect. The composition is substantially free of the S-enantiomer of the R-NSAID. Therapeutic use of the composition is accompagnied by reduced adverse side effects.

公开(公告)号：WO1996028148A2

公开(公告)日：1996-09-19

申请号：PCT/US1996003495

申请日：1996-03-13

Applicant: LOMA LINDA UNIVERSITY MEDICAL CENTER ,  WECHTER, William, J. ,  McCRACKEN, John, D.

Inventor： LOMA LINDA UNIVERSITY MEDICAL CENTER

IPC: A61K31/19

CPC classification number: A61K31/192

Abstract: A composition for use in preventing colorectal cancer and other neoplactic diseases includes an enantiomerically stable R-NSAID or a pharmaceutically acceptable salt thereof in an amount effective to elicit a chemoprotective effect. The composition is substantially free of the S-enantiomer of the R-NSAID. Therapeutic use of the composition is accompagnied by reduced adverse side effects.

Abstract translation: 用于预防结肠直肠癌和其他肿瘤疾病的组合物包括有效引发化学保护作用的量的对映异构体稳定的R-NSAID或其药学上可接受的盐。 组合物基本上不含R-NSAID的S-对映异构体。 组合物的治疗用途伴随着不良副作用减少。