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1.发明申请XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS FOR ETHANOL PRODUCTION 审中-公开用于乙醇生产的XYLOSE-ZYMOMONAS的XYLITOL合成突变体
公开(公告)号：WO2008133638A2
公开(公告)日：2008-11-06
申请号：PCT/US2007020950
申请日：2007-09-28
Applicant: DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Inventor： VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Abstract: A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism.lt also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
Abstract translation: 用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了一种利用木糖的酵母菌菌株，导致GFOR酶活性的降低。 工程化的菌株表现出木糖代谢产物的减少，这是木糖代谢的有害副产物。在过程相关条件下，混合糖发酵过程中还会消耗更多的木糖并产生更多的乙醇。
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2.发明申请IMPROVED ETHANOL PRODUCT I ON IN FERMENTATION OF MIXED SUGARS CONTAINING XYLOSE IN THE PRESENCE OF SUGAR ALCOHOLS 审中-公开改进的乙醇产品I在糖乳液存在下发酵中含有XYLOSE的混合糖
公开(公告)号：WO2008051349A3
公开(公告)日：2008-08-07
申请号：PCT/US2007020946
申请日：2007-09-28
Applicant: DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , LI XU , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
Inventor： VIITANEN PAUL V , MCCUTCHEN CAROL M , LI XU , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN , FRANDEN MARY ANN
IPC: C12N1/00
Abstract: Xylose-utilizing Z. mobilis strains were found to have improved ethanol production when grown in medium containing mixed sugars including xylose if sorbitol or mannitol was included in the medium. The effect was seen in concentrations of mixed sugars where no growth lag period occurs, as well as in higher sugars concentrations.
Abstract translation: 当发现含木糖的运动发酵单胞菌菌株在含有木糖的混合糖的培养基中生长时，如果在培养基中包含山梨糖醇或甘露醇，则发现其具有改善的乙醇生产。 在没有生长滞后期的混合糖的浓度以及较高的糖浓度下观察到效果。
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Patent Agency Ranking3.发明申请IMPROVED ETHANOL PRODUCTION IN FERMENTATION OF MIXED SUGARS CONTAINING XYLOSE 审中-公开在含有XYLOSE的混合糖的发酵中改进乙醇生产
公开(公告)号：WO2008051349A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/020946
申请日：2007-09-28
Applicant: E. I. DU PONT DE NEMOURS AND COMPANY , MIDWEST RESEARCH INSTITUTE , VIITANEN, Paul, V. , MCCUTCHEN, Carol, M. , LI, Xu , EMPTAGE, Mark , CAIMI, Perry, G. , ZHANG, Min , CHOU, Yat-Chen , FRANDEN, Mary, Ann
Inventor： VIITANEN, Paul, V. , MCCUTCHEN, Carol, M. , LI, Xu , EMPTAGE, Mark , CAIMI, Perry, G. , ZHANG, Min , CHOU, Yat-Chen , FRANDEN, Mary, Ann
IPC: C12N1/00
Abstract: Xylose-utilizing Z. mobilis strains were found to have improved ethanol production when grown in medium containing mixed sugars including xylose if sorbitol or mannitol was included in the medium. The effect was seen in concentrations of mixed sugars where no growth lag period occurs, as well as in higher sugars concentrations.
Abstract translation: 当发现含木糖的运动发酵单胞菌菌株在含有木糖的混合糖的培养基中生长时，如果在培养基中包含山梨糖醇或甘露醇，则发现其具有改善的乙醇生产。 在没有生长滞后期的混合糖的浓度以及较高的糖浓度下观察到效果。
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4.发明申请ETHANOL PRODUCTION USING XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS 审中-公开使用XYLITOL合成的XYLOSE-ZYMOMONAS合成酶的乙醇生产
公开(公告)号：WO2008051348A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/020945
申请日：2007-09-28
Applicant: E. I. DU PONT DE NEMOURS AND COMPANY , MIDWEST RESEARCH INSTITUTE , VIITANEN, Paul, V. , MCCUTCHEN, Carol, M. , EMPTAGE, Mark , CAIMI, Perry, G. , ZHANG, Min , CHOU, Yat-Chen
Inventor： VIITANEN, Paul, V. , MCCUTCHEN, Carol, M. , EMPTAGE, Mark , CAIMI, Perry, G. , ZHANG, Min , CHOU, Yat-Chen
Abstract: Production of ethanol using a strain of xylose-utilizing Z ymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.
Abstract translation: 发现使用具有葡萄糖 - 果糖氧化还原酶基因的遗传修饰的具有木糖利用的酵母菌菌株的乙醇的生产由于发酵期间合成的木糖代谢的有害副产物木糖醇的产生大大降低而得到改善。
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5.发明申请XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS FOR ETHANOL PRODUCTION 审中-公开用于乙醇生产的XYLOSE-ZYMOMONAS的XYLITOL合成突变体
公开(公告)号：WO2008133638A3
公开(公告)日：2009-01-29
申请号：PCT/US2007020950
申请日：2007-09-28
Applicant: DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Inventor： VIITANEN PAUL V , MCCUTCHEN CAROL M , CHOU YAT-CHEN , ZHANG MIN
Abstract: A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism.lt also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
Abstract translation: 用葡萄糖 - 果糖氧化还原酶基因的遗传修饰工程改造了一种利用木糖的酵母菌菌株，导致GFOR酶活性的降低。 工程化的菌株表现出木糖代谢产物的减少，这是木糖代谢的有害副产物。在过程相关条件下，混合糖发酵过程中还会消耗更多的木糖并产生更多的乙醇。
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公开(公告)号：WO2008133638A9
公开(公告)日：2008-11-06
申请号：PCT/US2007/020950
申请日：2007-09-28
Applicant: E. I. DU PONT DE NEMOURS AND COMPANY , MIDWEST RESEARCH INSTITUTE , VIITANEN, Paul, V. , MCCUTCHEN, Carol, M. , CHOU, Yat-Chen , ZHANG, Min
Inventor： VIITANEN, Paul, V. , MCCUTCHEN, Carol, M. , CHOU, Yat-Chen , ZHANG, Min
Abstract: A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism.lt also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
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7.发明申请ETHANOL PRODUCTION USING XYLITOL SYNTHESIS MUTANT OF XYLOSE-UTILIZING ZYMOMONAS 审中-公开用木糖醇合成突变型木糖醇突变株生产乙醇
公开(公告)号：WO2008051348A3
公开(公告)日：2008-09-12
申请号：PCT/US2007020945
申请日：2007-09-28
Applicant: DU PONT , MIDWEST RESEARCH INST , VIITANEN PAUL V , MCCUTCHEN CAROL M , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN
Inventor： VIITANEN PAUL V , MCCUTCHEN CAROL M , EMPTAGE MARK , CAIMI PERRY G , ZHANG MIN , CHOU YAT-CHEN
Abstract: Production of ethanol using a strain of xylose-utilizing Zymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.
Abstract translation: 发现使用具有葡萄糖 - 果糖氧化还原酶基因的遗传修饰的利用木糖的发酵单胞菌菌株生产乙醇，由于木糖醇的产生大大降低，木糖醇是发酵期间合成的木糖代谢的有害副产物，所以发现其得到改善。
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