公开(公告)号：WO2012016097A3

公开(公告)日：2012-02-02

申请号：PCT/US2011/045809

申请日：2011-07-29

Applicant: NOVARTIS AG ,  CHANG, Frank ,  SCOTT, Robert ,  HUANG, Jinyu ,  MEDINA, Arturo, N. ,  SMITH, Dawn, A. ,  SANDERS, Laura, Ann ,  PRUITT, John, Dallas

Inventor： CHANG, Frank ,  SCOTT, Robert ,  HUANG, Jinyu ,  MEDINA, Arturo, N. ,  SMITH, Dawn, A. ,  SANDERS, Laura, Ann ,  PRUITT, John, Dallas

IPC: C08F26/02 ,  C08F226/00

Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

公开(公告)号：WO2012016098A1

公开(公告)日：2012-02-02

申请号：PCT/US2011/045810

申请日：2011-07-29

Applicant: NOVARTIS AG ,  QIU, Yongxing ,  SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  KOLLURU, Chandana ,  MEDINA, Arturo, N. ,  WINTERTON, Lynn, Cook ,  WU, Daqing ,  QIAN, Xinming ,  NELSON, Jared

Inventor： QIU, Yongxing ,  SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  KOLLURU, Chandana ,  MEDINA, Arturo, N. ,  WINTERTON, Lynn, Cook ,  WU, Daqing ,  QIAN, Xinming ,  NELSON, Jared

IPC: G02C7/04 ,  B05D5/06 ,  B29D11/00

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: A cost-effective method for making a silicone hydrogel contact lens has a crosslinked hydrophilic coating applied thereon. The method involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally- crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, and at a temperature from 40 Centigrade to 140 Centigrade for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

Abstract translation: 制造硅酮水凝胶隐形眼镜的成本有效的方法具有涂覆在其上的交联的亲水涂层。 该方法包括在具有带正电的氮杂环丁烷基团的水溶性，高度支化，可热交联的亲水性聚合物材料的存在下，在40℃至140℃的温度存在下，在水溶液中加热硅氧烷水凝胶隐形眼镜，用于 足以将热交联亲水性聚合物材料共价连接到硅酮水凝胶隐形眼镜的表面上的共价键，每个共价键在硅氧烷水凝胶的表面上和/或附近的一个氮杂环丁烷基与一个反应性官能团之间形成 接触透镜，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

公开(公告)号：WO2012016097A2

公开(公告)日：2012-02-02

申请号：PCT/US2011045809

申请日：2011-07-29

Applicant: NOVARTIS AG ,  CHANG FRANK ,  SCOTT ROBERT ,  HUANG JINYU ,  MEDINA ARTURO N ,  SMITH DAWN A ,  SANDERS LAURA ANN ,  PRUITT JOHN DALLAS

Inventor： CHANG FRANK ,  SCOTT ROBERT ,  HUANG JINYU ,  MEDINA ARTURO N ,  SMITH DAWN A ,  SANDERS LAURA ANN ,  PRUITT JOHN DALLAS

IPC: G02C7/04 ,  B29D11/00 ,  C07F7/10 ,  G02B1/12

CPC classification number: G02B1/043 ,  C08F290/068 ,  C08G77/388 ,  C08G77/458 ,  C08G2210/00 ,  C08L2205/02 ,  C08L83/04 ,  C08L51/085 ,  C08L101/14 ,  C08F220/56 ,  C08F220/28

Abstract: The present invention provides an amphiphilic polysiloxane prepolymer which comprises hydrophilic monomeric units derived from at least one hydrophilic vinylic monomer, polysiloxane crosslinking units derived from at least one polysiloxane crosslinker having at least two terminal ethylenically-unsaturated groups, dangling polysiloxane chains each of which is terminated with one ethylenically unsaturated group, and chain-transfer units derived from a chain transfer agent other than a RAFT agent. A prepolymer of the invention is suitable for making hydrogel contact lenses. The present invention is also related to hydrogel contact lenses made from an amphiphilic polysiloxane prepolymer of the invention and to processes for preparing an amphiphilic polysiloxane prepolymer of the invention and for making silicone hydrogel contact lenses.

Abstract translation: 本发明提供一种两亲性聚硅氧烷预聚物，其包含衍生自至少一种亲水乙烯基单体的亲水性单体单元，衍生自至少一种具有至少两个末端烯属不饱和基团的聚硅氧烷交联剂的聚硅氧烷交联单元，悬浮聚硅氧烷链各自被终止 具有一个烯键式不饱和基团，以及衍生自除RAFT试剂之外的链转移剂的链转移单元。 本发明的预聚物适用于制备水凝胶隐形眼镜。 本发明还涉及由本发明的两亲聚硅氧烷预聚物制成的水凝胶隐形眼镜以及制备本发明的两亲性聚硅氧烷预聚物和制备硅酮水凝胶隐形眼镜的方法。