公开(公告)号：WO2012078457A1

公开(公告)日：2012-06-14

申请号：PCT/US2011/062986

申请日：2011-12-02

Applicant: NOVARTIS AG ,  SAMUEL, Newton, T. ,  HUANG, Horngyih ,  WU, Daqing ,  HAKEN, Uwe ,  PRUITT, John, Dallas ,  DOMSCHKE, Angelika, Maria ,  MATSUZAWA, Yasuo

Inventor： SAMUEL, Newton, T. ,  HUANG, Horngyih ,  WU, Daqing ,  HAKEN, Uwe ,  PRUITT, John, Dallas ,  DOMSCHKE, Angelika, Maria ,  MATSUZAWA, Yasuo

IPC: B29D11/00

CPC classification number: B29D11/00153 ,  B08B9/00 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14

Abstract: The invention provides a method for washing, with a water-based system, reusable molds for making silicone hydrogel contact lenses. The water-based washing system comprises an ethoxylated silicone polyether surfactant. The water-based system of the invention can effectively wash away silicone-containing components and other components of a lens formulation left behind on the molding surfaces of a reusable mold, after removing a silicone hydrogel contact lens cast molded in the reusable mold.

Abstract translation: 本发明提供了一种用水洗系统清洗可重复使用的模具以制造硅酮水凝胶隐形眼镜的方法。 水基洗涤系统包括乙氧基化硅氧烷聚醚表面活性剂。 在去除在可重复使用的模具中铸造的硅酮水凝胶隐形眼镜之后，本发明的水基系统可以有效地洗掉留在可重复使用的模具的模制表面上的透镜制剂的含硅酮组分和其它组分。

公开(公告)号：WO2012016098A1

公开(公告)日：2012-02-02

申请号：PCT/US2011/045810

申请日：2011-07-29

Applicant: NOVARTIS AG ,  QIU, Yongxing ,  SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  KOLLURU, Chandana ,  MEDINA, Arturo, N. ,  WINTERTON, Lynn, Cook ,  WU, Daqing ,  QIAN, Xinming ,  NELSON, Jared

Inventor： QIU, Yongxing ,  SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  KOLLURU, Chandana ,  MEDINA, Arturo, N. ,  WINTERTON, Lynn, Cook ,  WU, Daqing ,  QIAN, Xinming ,  NELSON, Jared

IPC: G02C7/04 ,  B05D5/06 ,  B29D11/00

CPC classification number: C09D177/06 ,  B29D11/00067 ,  C08G77/388 ,  C08J5/00 ,  C08J7/042 ,  C08J2383/04 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2433/26 ,  C08J2487/00 ,  C08L83/04 ,  C09D5/1637 ,  C09D5/1681 ,  C09D133/02 ,  C09D133/14 ,  C09D133/26 ,  C09D171/02 ,  G02B1/043 ,  G02B1/10 ,  G02B1/18 ,  G02C7/049 ,  G02C2202/06 ,  G02C2202/16 ,  C08L101/14

Abstract: A cost-effective method for making a silicone hydrogel contact lens has a crosslinked hydrophilic coating applied thereon. The method involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally- crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, and at a temperature from 40 Centigrade to 140 Centigrade for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.

Abstract translation: 制造硅酮水凝胶隐形眼镜的成本有效的方法具有涂覆在其上的交联的亲水涂层。 该方法包括在具有带正电的氮杂环丁烷基团的水溶性，高度支化，可热交联的亲水性聚合物材料的存在下，在40℃至140℃的温度存在下，在水溶液中加热硅氧烷水凝胶隐形眼镜，用于 足以将热交联亲水性聚合物材料共价连接到硅酮水凝胶隐形眼镜的表面上的共价键，每个共价键在硅氧烷水凝胶的表面上和/或附近的一个氮杂环丁烷基与一个反应性官能团之间形成 接触透镜，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。

公开(公告)号：WO2008124756A1

公开(公告)日：2008-10-16

申请号：PCT/US2008/059732

申请日：2008-04-09

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO ,  GERA, Lajos ,  STEWART, John, M. ,  CHUNG, Leland, W. ,  WU, Daqing

Inventor： GERA, Lajos ,  STEWART, John, M. ,  CHUNG, Leland, W. ,  WU, Daqing

IPC: A01N43/04 ,  A61K31/70

CPC classification number: C07F9/405 ,  C07F9/598

Abstract: Small molecule bradykinin inhibitor bisphosphonate amide derivatives useful for inhibiting cancer growth and treating cancer residing in and around bone are disclosed. These compounds and pharmaceutical compositions containing these compounds are particularly useful for the treatment of prostate cancer bone metastases.

Abstract translation: 公开了用于抑制癌症生长和治疗存在于骨骼内和周围的癌症的小分子缓激肽抑制剂双膦酸酯衍生物。 这些化合物和含有这些化合物的药物组合物特别可用于治疗前列腺癌骨转移。

公开(公告)号：WO2010071691A1

公开(公告)日：2010-06-24

申请号：PCT/US2009/047428

申请日：2009-06-16

Applicant: NOVARTIS AG ,  CHANG, Frank ,  VOGT, Jürgen ,  PRUITT, John, Dallas ,  QIAN, Xinming ,  SMITH, Dawn, A. ,  DOMSCHKE, Angelika, Maria ,  HOLLAND, Troy, Vernon ,  TUREK, Richard, Charles ,  WU, Daqing

Inventor： CHANG, Frank ,  VOGT, Jürgen ,  PRUITT, John, Dallas ,  QIAN, Xinming ,  SMITH, Dawn, A. ,  DOMSCHKE, Angelika, Maria ,  HOLLAND, Troy, Vernon

IPC: G02B1/04

CPC classification number: G02B1/043 ,  C08F283/124 ,  C08L83/04 ,  C08L51/085

Abstract: A method for producing silicone hydrogel contact lenses and silicon hydrogel contact lens thereof. The method comprising the steps of: providing a mold for making a soft contact lens, wherein the mold has a first mold half with a first molding surface defining the anterior surface of a contact lens and a second mold half with a second molding surface defining the posterior surface of the contact lens, wherein said first and second mold halves are configured to receive each other such that a cavity is formed between said first and second molding surfaces; introduce a monomer mixture of lens-forming materials into the cavity, wherein the monomer mixture comprises at least one hydrophilic amide-type vinylic monomer, at least one siloxane-containing (meth)acrylamide monomer, at least one polysiloxane vinylic monomer or macromer, and from about 0.05 % to about 1.5 % by weight of a photoinitiator, wherein the lens forming material is characterized by having an ability to be cured by a UV light having an UV-intensity of about 4.1 mW/cm 2 within about 100 seconds; and irradiating, under a spatial limitation of actinic radiation, the lens-forming material in the mold for a time period of about 120 seconds or less, so as to crosslink the lens-forming material to form the silicone hydrogel contact lens, wherein the produced contact lens comprises an anterior surface defined by the first molding surface, an opposite posterior surface defined by the second molding surface, and a lens edge defined by the spatial limitation of actinic radiation.

Abstract translation: 硅酮水凝胶隐形眼镜及其硅水凝胶隐形眼镜的制造方法。 该方法包括以下步骤：提供用于制造软性隐形眼镜的模具，其中所述模具具有第一半模，其具有限定隐形眼镜的前表面的第一模制表面和具有限定所述隐形眼镜的第二模制表面的第二半模 接触透镜的后表面，其中所述第一和第二半模被配置为彼此接收，使得在所述第一和第二模制表面之间形成空腔; 将透镜形成材料的单体混合物引入空腔中，其中单体混合物包含至少一种亲水性酰胺型乙烯基单体，至少一种含硅氧烷的（甲基）丙烯酰胺单体，至少一种聚硅氧烷乙烯基单体或大分子单体，以及 约0.05重量％至约1.5重量％的光引发剂，其中所述透镜形成材料的特征在于具有在约100秒内具有约4.1mW / cm 2的UV强度的UV光固化的能力; 并且在光化辐射的空间限制下将模具中的透镜形成材料照射大约120秒或更短的时间，以使透镜形成材料交联以形成硅氧水凝胶隐形眼镜，其中所产生的 隐形眼镜包括由第一成型表面限定的前表面，由第二成型表面限定的相对的后表面和由光化辐射的空间限制限定的透镜边缘。

公开(公告)号：WO2006044486A2

公开(公告)日：2006-04-27

申请号：PCT/US2005/036731

申请日：2005-10-13

Applicant: DENZAI THERAPEUTICS CORPORATION ,  CHUNG, Leland, W., K. ,  HUANG, Wen-Chin ,  ODERO-MARAH, Valerie ,  WU, Daqing ,  HSIEH, Chia-Ling ,  ZHAU, Haiyen

Inventor： CHUNG, Leland, W., K. ,  HUANG, Wen-Chin ,  ODERO-MARAH, Valerie ,  WU, Daqing ,  HSIEH, Chia-Ling ,  ZHAU, Haiyen

IPC: A61K48/00

CPC classification number: A61K31/70 ,  A61K48/00 ,  C07K16/22 ,  C07K16/2833 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  G01N33/5011

Abstract: The present invention relates to compositions and methods for modulating osteomimicry within tumor and tissue cells with calcification potential. The invention further relates to screening compounds that modulate osteomimicry within tumor and tissue cells with calcification potential. Methods for using compounds identified by the screening assays for therapeutic treatments also are provided. The invention further relates to methods of treating those tumors and other diseases and disorders with calcification potential with compounds that modulate their osteomimetic potential.

Abstract translation: 本发明涉及在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的组合物和方法。 本发明进一步涉及筛选在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的化合物。 还提供了通过筛选测定法鉴定的化合物用于治疗性治疗的方法。 本发明还涉及用调节其骨骼模拟潜能的化合物治疗具有钙化潜能的那些肿瘤和其它疾病和病症的方法。

公开(公告)号：WO2012015639A1

公开(公告)日：2012-02-02

申请号：PCT/US2011/044618

申请日：2011-07-20

Applicant: NOVARTIS AG ,  SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  WU, Daqing ,  KUYU, Selma

Inventor： SAMUEL, Newton, T. ,  PRUITT, John, Dallas ,  WU, Daqing ,  KUYU, Selma

IPC: G02C7/04 ,  C08L83/04

CPC classification number: G02B1/043 ,  B29D11/00038 ,  B29D11/00048 ,  G02C7/04 ,  G02C7/049 ,  C08L101/14

Abstract: Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.

Abstract translation: 本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。 与使紫外线吸收性隐形眼镜相关的常规方法与包含紫外线吸收性乙烯基单体的透镜形成组合物共聚，本发明的方法涉及将具有第二反应性官能团的紫外线吸收性化合物与 其中和/或其上具有第一反应性官能团的预成型隐形眼镜。

公开(公告)号：WO2006044486A3

公开(公告)日：2007-04-12

申请号：PCT/US2005036731

申请日：2005-10-13

Applicant: DENZAI THERAPEUTICS CORP ,  CHUNG LELAND W K ,  HUANG WEN-CHIN ,  ODERO-MARAH VALERIE ,  WU DAQING ,  HSIEH CHIA-LING ,  ZHAU HAIYEN

Inventor： CHUNG LELAND W K ,  HUANG WEN-CHIN ,  ODERO-MARAH VALERIE ,  WU DAQING ,  HSIEH CHIA-LING ,  ZHAU HAIYEN

IPC: A61K31/70 ,  C07H21/04 ,  C12Q1/68

CPC classification number: A61K31/70 ,  A61K48/00 ,  C07K16/22 ,  C07K16/2833 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  G01N33/5011

Abstract: The present invention relates to compositions and methods for modulating osteomimicry within tumor and tissue cells with calcification potential. The invention further relates to screening compounds that modulate osteomimicry within tumor and tissue cells with calcification potential. Methods for using compounds identified by the screening assays for therapeutic treatments also are provided. The invention further relates to methods of treating those tumors and other diseases and disorders with calcification potential with compounds that modulate their osteomimetic potential.

Abstract translation: 本发明涉及在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的组合物和方法。 本发明进一步涉及筛选在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的化合物。 还提供了通过筛选测定法鉴定的化合物用于治疗性治疗的方法。 本发明还涉及用调节其骨骼模拟潜能的化合物治疗具有钙化潜能的那些肿瘤和其它疾病和病症的方法。

公开(公告)号：WO2012047969A1

公开(公告)日：2012-04-12

申请号：PCT/US2011/054878

申请日：2011-10-05

Applicant: NOVARTIS AG ,  HUANG, Jinyu ,  CHANG, Frank ,  SCOTT, Robert ,  MEDINA, Arturo Norberto ,  SHANKERNARAYANAN, Manivakkam J. ,  KUYU, Selma ,  SMITH, Dawn, Alison ,  WU, Daqing

Inventor： HUANG, Jinyu ,  CHANG, Frank ,  SCOTT, Robert ,  MEDINA, Arturo Norberto ,  SHANKERNARAYANAN, Manivakkam J. ,  KUYU, Selma ,  SMITH, Dawn, Alison ,  WU, Daqing

IPC: C08G77/42 ,  C08G77/442 ,  C08L83/10 ,  G02B1/04 ,  C08G77/20

CPC classification number: G02B1/043 ,  C08G77/20 ,  C08G77/42 ,  C08G77/442 ,  C08J3/075 ,  C08J2343/04 ,  C08J2383/08 ,  C08L83/10 ,  C08L101/14 ,  C08L83/04

Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

Abstract translation: 本发明提供了一类可水加工的可聚合预聚物，其包含（1）衍生自至少一种含有一个含硅氧烷的单体的含硅氧烷的单体单元，所述单体具有一个亲水基团或至少一种亲水化聚硅氧烷的链和/或含聚硅氧烷的交联单元，或 链延长聚硅氧烷交联剂; （2）衍生自一种或多种亲水乙烯基单体的亲水单体单元; 和（3）约0.05％至约5％重量的各自具有侧基或末端的可聚合单元，烯属不饱和基团并且不含任何聚硅氧烷链段。 预聚物相对于预聚物的总重量包含约20重量％至约50重量％的硅氧烷，并且在水中具有至少约5重量％的高水溶性或分散性，并且适于制备硅酮水凝胶隐形眼镜。

公开(公告)号：WO2011071791A1

公开(公告)日：2011-06-16

申请号：PCT/US2010/059022

申请日：2010-12-06

Applicant: NOVARTIS AG ,  SAMUEL, Newton, T. ,  WU, Daqing

Inventor： SAMUEL, Newton, T. ,  WU, Daqing

IPC: C08L43/02 ,  G02C7/04

CPC classification number: G02B1/043 ,  C08L101/14 ,  C08L51/085

Abstract: The invention provides a cost-effective method for making a silicone hydrogel contact lens having a hydrophilic coating thereon that is covalently attached to the lens and has a good hydrophilicity, intactness and durability. The invention also provides a silicone hydrogel contact lenses having a hydrophilic coating consisting of a prime coating covalently attached to the contact lens and a top coating covalently attached to the prime coating.

Abstract translation: 本发明提供了一种制备其上具有共价连接到透镜上并具有良好的亲水性，完整性和耐久性的亲水涂层的硅酮水凝胶隐形眼镜的成本有效的方法。 本发明还提供一种具有亲水性涂层的硅酮水凝胶隐形眼镜，该亲水性涂层由共价连接到隐形眼镜的主涂层和共价连接到主涂层的顶涂层组成。

公开(公告)号：WO2011056761A1

公开(公告)日：2011-05-12

申请号：PCT/US2010/055033

申请日：2010-11-02

Applicant: NOVARTIS AG ,  WU, Daqing ,  QIAN, Xinming ,  PRUITT, John, Dallas

Inventor： WU, Daqing ,  QIAN, Xinming ,  PRUITT, John, Dallas

IPC: G02C7/04

CPC classification number: G02C7/04 ,  G02B1/043 ,  C08L101/14

Abstract: The invention provides a cost-effective method for applying a hydrophilic coating onto a silicone hydrogel contact lens based on Fenton chemistry. The hydrophilic coating is covalently attached onto the contact lens at room temperature without UV irradiation. The invention also provides a silicone hydrogel contact lenses having a hydrophilic coating obtained according to the method of the invention.

Abstract translation: 本发明提供了一种基于Fenton化学将亲水性涂层施加到硅酮水凝胶隐形眼镜上的成本有效的方法。 亲水涂层在室温下共价附着在隐形眼镜上，无紫外线照射。 本发明还提供了具有根据本发明方法获得的亲水涂层的硅酮水凝胶隐形眼镜。