公开(公告)号：WO2009006548A3

公开(公告)日：2009-03-19

申请号：PCT/US2008069085

申请日：2008-07-02

Applicant: NONO INC ,  ARBOR VITA CORP ,  TASKER ANDREW ,  DOUCETTE TRACY ,  TYMIANSKI MICHAEL ,  MENDOZA KENNETH ,  BELMARES MICHAEL P ,  GARMAN DAVID ,  LU PETER S

Inventor： TASKER ANDREW ,  DOUCETTE TRACY ,  TYMIANSKI MICHAEL ,  MENDOZA KENNETH ,  BELMARES MICHAEL P ,  GARMAN DAVID ,  LU PETER S

IPC: A61K38/04 ,  C12P21/04

CPC classification number: A61K38/1787 ,  A61K38/07

Abstract: The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.

Abstract translation: 本发明提供了治疗或有效预防患有焦虑症状或具有发展焦虑症状风险的患者的方法，其中向患者施用抑制PSD95与NMDA受体的特异性结合的药剂的有效方案。

公开(公告)号：WO2009006611A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/069230

申请日：2008-07-03

Applicant: ARBOR VITA CORPORATION ,  NONO, INC. ,  BELMARES, Michael, P. ,  MENDOZA, Kenneth, A. ,  LU, Peter, S. ,  GARMAN, David ,  TYMIANSKI, Michael

Inventor： BELMARES, Michael, P. ,  MENDOZA, Kenneth, A. ,  LU, Peter, S. ,  GARMAN, David ,  TYMIANSKI, Michael

IPC: A01N47/28 ,  A61K31/17

CPC classification number: A61K31/17

Abstract: The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.

Abstract translation: 本发明涉及用于调节与同源配体的PDZ结构域相互作用的组合物。 还提供了评估和表征各种多肽的PDZ结构域相互作用的方法。

公开(公告)号：WO2007079406A1

公开(公告)日：2007-07-12

申请号：PCT/US2006/062715

申请日：2006-12-29

Applicant: ARBOR VITA CORPORATION ,  BELMARES, Michael, P. ,  LU, Peter, S. ,  MENDOZA, Kenneth, A.

Inventor： BELMARES, Michael, P. ,  LU, Peter, S. ,  MENDOZA, Kenneth, A.

IPC: A61K31/192 ,  A61K31/436 ,  A61P25/04 ,  A61P9/10

CPC classification number: A61K31/192 ,  A61K31/436

Abstract: The present invention relates to compositions for use in the modulation of PDZ domain interactions with cognate ligands. Methods of assessing and characterizing PDZ domain interactions from various polypeptides also are provided.

Abstract translation: 本发明涉及用于调节与同源配体的PDZ结构域相互作用的组合物。 还提供了评估和表征各种多肽的PDZ结构域相互作用的方法。

公开(公告)号：WO2009006548A2

公开(公告)日：2009-01-08

申请号：PCT/US2008/069085

申请日：2008-07-02

Applicant: NONO, INC. ,  ARBOR VITA CORPORATION ,  TASKER, Andrew ,  DOUCETTE, Tracy ,  TYMIANSKI, Michael ,  MENDOZA, Kenneth ,  BELMARES, Michael, P. ,  GARMAN, David ,  LU, Peter, S.

Inventor： TASKER, Andrew ,  DOUCETTE, Tracy ,  TYMIANSKI, Michael ,  MENDOZA, Kenneth ,  BELMARES, Michael, P. ,  GARMAN, David ,  LU, Peter, S.

IPC: A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61P25/22

CPC classification number: A61K38/1787 ,  A61K38/07

Abstract: The invention provides methods of treating or effecting prophylaxis of a patient having or at risk of developing symptoms of anxiety in which an effective regime of an agent that inhibits specific binding of PSD95 to an NMDA receptor is administered to a patient.

Abstract translation: 本发明提供了治疗或预防患有或有发生焦虑症状的患者的方法，其中向患者施用抑制PSD95与NMDA受体的特异性结合的药剂的有效方案。