公开(公告)号：WO2009026253A2

公开(公告)日：2009-02-26

申请号：PCT/US2008/073517

申请日：2008-08-18

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  LABDAG, Fatima-ezzahra ,  BADESHA, Jasbir

Inventor： LABDAG, Fatima-ezzahra ,  BADESHA, Jasbir

IPC: A61B17/00 ,  A61M29/00

CPC classification number: A61B17/12022 ,  A61B17/12145 ,  A61B17/12154 ,  A61B2017/00526

Abstract: A flexible metal wire coil is formed with a twisted coil pattern, by forming a primary coil on a special mandrel formed from two or more strands of material twisted helically about a longitudinal axis to have a helical shape. The primary coil wire is wound around the mandrel to give the primary coil a twisted shape corresponding to the helical shape of the mandrel.

Abstract translation: 柔性金属线圈通过在由两条或更多条材料线形成的特殊心轴上形成具有扭曲线圈图案的初级线圈，所述两条或更多线材围绕纵向轴线螺旋地扭曲以具有螺旋形状。 初级线圈绕线缠绕在心轴上以使初级线圈成为与心轴的螺旋形状对应的扭曲形状。

公开(公告)号：WO2008115430A1

公开(公告)日：2008-09-25

申请号：PCT/US2008/003428

申请日：2008-03-14

Applicant: MICRUS ENDOVASCULAR CORPORATION

Inventor： WATSON, David, A.

IPC: A61M25/06

CPC classification number: A61M25/09041 ,  A61B2017/00469 ,  A61B2017/22038 ,  A61M25/0612 ,  A61M25/0662

Abstract: The improved guidewire introducer and shaping tool (10) includes a polymer inner layer (14) and a metal outer layer (12). A polymer luer hub (18) is provided on a polymer tubing shaft so that the internal taper (20) of the hub has a smooth transition to the inner diameter of the polymer tubing shaft. A metal outer layer is provided over the outer surface of the polymer layer and can be rigidly attached to the hub to provide support and stiffness to the polymer layer.

Abstract translation: 改进的导丝导引器和成形工具（10）包括聚合物内层（14）和金属外层（12）。 聚合物鲁尔轮毂（18）设置在聚合物管轴上，使得轮毂的内锥形件（20）平滑地过渡到聚合物管轴的内径。 金属外层设置在聚合物层的外表面之上，并且可以刚性地附接到轮毂，以为聚合物层提供支撑和刚度。

公开(公告)号：WO2008076552A1

公开(公告)日：2008-06-26

申请号：PCT/US2007/084441

申请日：2007-11-12

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  BRETON, Thomas G. ,  PADILLA, Neal H. ,  ASUNCION, Sheila V.

Inventor： BRETON, Thomas G. ,  PADILLA, Neal H. ,  ASUNCION, Sheila V.

IPC: A61M25/00

CPC classification number: A61M25/0105 ,  A61M25/0041 ,  A61M25/0152 ,  A61M25/0662 ,  A61M2025/0681

Abstract: The catheter shape-retaining cover (30) includes an elongated tubular member (32) having a predetermined non-linear shape and one or more inner lumens (38) to receive a distal tip (42) of a catheter (44). A tubular dispenser (52) for the catheter may be attached to the elongated tubular member. A shaped mandrel (72) may be placed in a first inner lumen (68) of the sheath. The assembly may be heated to a temperature that makes the distal tip of the catheter become more plastic, and then cooled to pre-set the shape of the distal tip of the catheter. The distal tip of the catheter also may be hydrated in an inner lumen of the sheath, and the catheter may be hydrated in the tubular dispenser.

Abstract translation: 导管形状保持盖（30）包括具有预定非线性形状的细长管状构件（32）和用于接收导管（44）的远侧末端（42）的一个或多个内腔（38）。 用于导管的管状分配器（52）可以附接到细长管状构件。 成形心轴（72）可以放置在护套的第一内腔（68）中。 组件可以被加热到使得导管的远侧末端变得更加塑性的温度，然后冷却以预先设定导管的远侧末端的形状。 导管的远侧末端也可以在护套的内腔中水合，并且导管可以在管状分配器中水合。

公开(公告)号：WO2009079410A1

公开(公告)日：2009-06-25

申请号：PCT/US2008/086691

申请日：2008-12-12

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  DEHNAD, Houdin

Inventor： DEHNAD, Houdin

IPC: A61B17/12

CPC classification number: A61B17/12113 ,  A61B17/12022 ,  A61B17/1214 ,  A61B17/12154 ,  A61B2017/00831

Abstract: The embolic coil includes a microcoil and an elongated wire electrically connected to the microcoil for accelerating embolization of an aneurysm into which the embolic coil is placed. The microcoil is formed of a first metallic material having a first reduction potential, and the elongated wire is formed of a second metallic material having a second reduction potential lower than the first reduction potential of the first metallic material.

Abstract translation: 栓塞线圈包括微线圈和电连接到微线圈的细长线，用于加速栓塞线圈放置在其中的动脉瘤的栓塞。 微线圈由具有第一还原电位的第一金属材料形成，并且细长线由具有低于第一金属材料的第一还原电位的第二还原电位的第二金属材料形成。

公开(公告)号：WO2008097973A1

公开(公告)日：2008-08-14

申请号：PCT/US2008/053053

申请日：2008-02-05

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  GOROSPE, Marcelino ,  SAN DIEGO, Edsel ,  HO, Thu Anh

Inventor： GOROSPE, Marcelino ,  SAN DIEGO, Edsel ,  HO, Thu Anh

IPC: A61B17/12

CPC classification number: B21C47/00 ,  A61B17/12022 ,  A61B17/12109 ,  A61B17/12145 ,  A61B2017/00526 ,  A61B2017/00867 ,  B21F45/008

Abstract: The winding mandrel includes a pair of generally rounded-cube shaped or orthogonally flat-sided spherical main bodies connected together and having a plurality of cylindrical posts for forming vasoocclusive coils. The main bodies are connected together by a transition post, and the posts of the two main bodies are typically offset. A front end post and back end post are disposed on the front and rear ends of the mandrel. A short winding post member may be added between the connections of the two main bodies to provide additional winding posts.

Abstract translation: 卷绕心轴包括一对连接在一起的大致圆形立方体或正交扁平的球形主体，并具有用于形成血管闭塞线圈的多个圆柱形支柱。 主体通过过渡柱连接在一起，两个主体的柱通常偏移。 前端柱和后端柱设置在心轴的前端和后端。 可以在两个主体的连接之间添加短的缠绕的柱状构件，以提供附加的缠绕柱。

公开(公告)号：WO2008079575A1

公开(公告)日：2008-07-03

申请号：PCT/US2007/085620

申请日：2007-11-27

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  LEVINE, Marc-Alan ,  HEBERT, Stephen ,  BRETON, Thomas, G. ,  WATSON, David, A.

Inventor： LEVINE, Marc-Alan ,  HEBERT, Stephen ,  BRETON, Thomas, G. ,  WATSON, David, A.

IPC: A61M25/00 ,  A61M25/01 ,  A61M25/09

CPC classification number: A61M25/008 ,  A61M25/0068 ,  A61M25/0136 ,  A61M25/0147 ,  A61M25/10 ,  A61M2025/015 ,  A61M2025/1079 ,  A61M2025/1093

Abstract: The long nose manipulatable catheter includes a main lumen (55), a wire lumen (60) with a push-pull wire (62) therethrough, and a flexible joint region. (58) The catheter section includes a control (240) including a handle (238) and a wire control (240) member engaging the push-pull wire for manipulating the flexible joint region. The push-pull wire (62) may be tapered, having a proximal portion of a first diameter and a smaller diameter distal portion. A coil may be placed around the smaller diameter to prevent buckling of the smaller diameter portion. A strapping coil may also disposed around the outside of the catheter,' and an outer covering may be disposed around the strapping. coil. An outer covering of a mesh may also be disposed around the distal tip of the catheter.

Abstract translation: 长鼻可操纵导管包括主腔（55），具有穿过其的推挽线（62）的线腔（60）和柔性接合区域。 （58）导管部分包括包括手柄（238）和接合推挽线的线控制（240）构件的控制器（240），用于操纵柔性接合区域。 推拉线（62）可以是锥形的，具有第一直径的近端部分和较小直径的远端部分。 线圈可以放置在较小直径周围以防止较小直径部分的弯曲。 捆扎线圈也可以围绕导管的外侧设置，并且可以在捆扎带周围设置外覆盖层。 线圈。 网的外覆盖物也可以设置在导管的远侧末端周围。

公开(公告)号：WO2010030991A1

公开(公告)日：2010-03-18

申请号：PCT/US2009/056835

申请日：2009-09-14

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  VEZNEDAROGLU, Erol, MD ,  GOROSPE, Marcelino ,  SAN DIEGO, Edsel

Inventor： VEZNEDAROGLU, Erol, MD ,  GOROSPE, Marcelino ,  SAN DIEGO, Edsel

IPC: A61B17/12

CPC classification number: A61B17/12022 ,  A61B17/12113 ,  A61B17/12172 ,  A61B2017/00867 ,  A61B2017/12054

Abstract: The self-expandable aneurysm filling device (102, 202), system and method provide for placement of the stent into an aneurysm (112) to at least partially fill and stabilize the aneurysm. The self -expandable aneurysm filling device (102) has a compressed undeployed configuration and an expanded three-dimensional deployed configuration, and a severable deployment junction (104, 204) releasably connects the self-expandable aneurysm filling device to a pusher wire (106, 206). The severable deployment junction can be mechanically, electrolytically, or thermally severed to separate the self-expandable aneurysm filling device from the pusher wire.

Abstract translation: 自膨胀动脉瘤充填装置（102,202），系统和方法提供将支架放置在动脉瘤（112）中以至少部分地填充和稳定动脉瘤。 自发性动脉瘤充填装置（102）具有压缩的未部署构型和扩展的三维展开构造，并且可分开的展开接头（104,204）可释放地将自膨胀动脉瘤填充装置连接到推动线（106， 206）。 可分离的部署接头可以机械地，电解地或热切断以将自膨胀动脉瘤充填装置与推进线分离。

公开(公告)号：WO2009089218A3

公开(公告)日：2009-07-16

申请号：PCT/US2009/030220

申请日：2009-01-06

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  LUNDKVIST, Andre, S. ,  WATSON, David, A.

Inventor： LUNDKVIST, Andre, S. ,  WATSON, David, A.

IPC: A61F2/90

Abstract: The intravascular stent is formed from a composite wire includes an inner core (12) of. radiopaque metal, a polymer layer (16) coaxially disposed abo.ut the inner core, and an outer metal layer (18) coaxially disposed about the polymer layer. The intermediary polymer layer acts as a barrier material between the inner core and the outer sheath, so that the inner core and outer sheath may be made of dissimilar metallic layers, and the intermediary polymer layer will prevent a galvanic reaction between the inner core and the peripheral metal layer. The intravascular stent (20) has ends (22, 24) flared radially outwardly to prevent radially and longitudinally inward deformation of the ends of the stent when the stent is disposed in a desired location in a patient's vasculature.

公开(公告)号：WO2009089216A2

公开(公告)日：2009-07-16

申请号：PCT/US2009/030217

申请日：2009-01-06

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  LUNDKVIST, Andre, S. ,  WATSON, David, A.

Inventor： LUNDKVIST, Andre, S. ,  WATSON, David, A.

IPC: A61F2/90

CPC classification number: B23P13/00 ,  A61B17/12118 ,  A61B2017/00526 ,  A61F2/86 ,  A61F2/90 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0039 ,  A61F2250/0098 ,  Y10T29/4998

Abstract: The intravascular stent is formed from a composite wire includes an inner core of radiopaque metal, a polymer layer coaxially disposed about the inner core, and an outer metal layer coaxially disposed about the polymer layer. The intermediary polymer layer acts as a barrier material between the inner core and the outer sheath, so that the inner core and outer sheath may be made of dissimilar metallic layers, and the intermediary polymer layer will prevent a galvanic reaction between the inner core and the peripheral metal layer. The intravascular stent has ends flared radially outwardly to prevent radially and longitudinally inward deformation of the ends of the stent when the stent is disposed in a desired location in a patient's vasculature.

Abstract translation: 血管内支架由包含不透射线金属的内芯，围绕内芯同轴布置的聚合物层和围绕聚合物层共轴布置的外金属层的复合线形成。 中间聚合物层用作内芯和外护套之间的阻挡材料，使得内芯和外护套可以由不同金属层制成，并且中间聚合物层将防止内芯和外护套之间的电流反应 外围金属层。 血管内支架具有径向向外张开的端部，以防止当支架布置在患者脉管系统中的期望位置时支架端部的径向和纵向向内变形。

公开(公告)号：WO2009062094A1

公开(公告)日：2009-05-14

申请号：PCT/US2008/082882

申请日：2008-11-07

Applicant: MICRUS ENDOVASCULAR CORPORATION ,  DEHNAD, Houdin

Inventor： DEHNAD, Houdin

IPC: A61B17/22 ,  A61F2/01

CPC classification number: A61B17/3207 ,  A61B17/221

Abstract: Disclosed is an apparatus and a method for removable of undesired material from body lumens. The apparatus may be used for fragmenting or removing a thrombus or occlusion from a blood vessel. The apparatus includes first shape segments and second shape segments connected to form a coiled member. A longitudinally extending tether is positioned inside the first shape segments and outside the second shape segments along the length of the coil. Applying a proximal force on the tether produces a change in the shape of at least a portion of the coil from a first generally linear configuration to a second complex three dimensional shape. A method of using the apparatus to engage and remove, or fragment, the thrombus or occlusion is disclosed.

Abstract translation: 公开了一种用于从体腔中去除不期望的材料的装置和方法。 该装置可用于从血管中分离或去除血栓或闭塞。 该装置包括连接形成线圈构件的第一形状段和第二形状段。 沿着线圈的长度，纵向延伸的系绳定位在第一形状段的内部和第二形状段的外部。 将近端力施加在系绳上产生线圈的至少一部分的形状从第一大致线性构型到第二复合三维形状的变化。 公开了一种使用该装置来接合和去除或分裂血栓或闭塞的方法。