公开(公告)号：WO2023092069A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/080141

申请日：2022-11-18

Applicant: MODERNATX, INC.

Inventor： STEWART-JONES, Guillaume ,  PARIS, Robert

IPC: A61K39/295 ,  A61P31/14 ,  A61K39/12

Abstract: The disclosure provides coronavirus mRNA vaccines, including booster vaccines, directed against one or more spike proteins of one or more variant strains of SARS-CoV-2, as well as methods of using the vaccines.

公开(公告)号：WO2023086465A1

公开(公告)日：2023-05-19

申请号：PCT/US2022/049537

申请日：2022-11-10

Applicant: MODERNATX, INC.

Inventor： CADETE PIRES, Ana ,  SUNG, Jean C. ,  CORNEBISE, Mark ,  HRKACH, Jeffrey

IPC: A61K9/51 ,  A61K31/7105 ,  C12N15/00 ,  A61P1/00 ,  A61P1/16 ,  A61P1/18 ,  A61P11/00 ,  A61P13/12 ,  A61P43/00

Abstract: The present disclosure provides LNPs comprising payload molecules, e.g., mRNA therapeutics, for the treatment of diseases or disorders, which would benefit from delivery of payload molecules to airway cells.

公开(公告)号：WO2023084013A1

公开(公告)日：2023-05-19

申请号：PCT/EP2022/081592

申请日：2022-11-11

Applicant: MODERNATX, INC.

Inventor： GAN, Li-Ming ,  ROSENMEIER, Jaya Birgitte

IPC: A61K31/7115 ,  A61K38/18 ,  A61P9/04 ,  A61P9/10 ,  A61P9/00

Abstract: This disclosure relates to compositions comprising modified RNA encoding VEGF-A, and the use of such compositions in methods of treating patients suffering from dilated cardiomyopathy and heart failure associated with dilated cardiomyopathy.

公开(公告)号：WO2023076598A1

公开(公告)日：2023-05-04

申请号：PCT/US2022/048223

申请日：2022-10-28

Applicant: MODERNATX, INC.

Inventor： SEEPERSAUD, Mohindra ,  CRAWFORD, Matthew ,  TATE, Daniel ,  CORNEBISE, Mark

IPC: C07J41/00 ,  C07J43/00 ,  A61K48/00

Abstract: Provided are lipid amine compounds which are useful in the preparation of lipid nanoparticle compositions for delivery of therapeutic or prophylactic payload into cells.

公开(公告)号：WO2023069625A1

公开(公告)日：2023-04-27

申请号：PCT/US2022/047288

申请日：2022-10-20

Applicant: MODERNATX, INC.

Inventor： GOLDMAN, Johnathan ,  SINGH, Satish K. ,  ZVEREV, Anton ,  SMITH, Michael H.

IPC: A61K9/127 ,  A61K9/51 ,  A61K47/26 ,  A61P43/00

Abstract: Provided herein are methods and compositions of a surrogate mRNA drug product. The surrogate mRNA drug product is made up of a physical property surrogate, a visual property surrogate, and a chemical property surrogate. The surrogate mRNA drug product has at least one quantitative or qualitative property such as viscosity, turbidity, density, and surface tension that is comparable to and matches the same property of a mRNA drug product comprised of mRNA in a lipid nanoparticle (LNP). The surrogate mRNA drug product, however, does not comprise mRNA or LNP.

公开(公告)号：WO2023018773A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/039921

申请日：2022-08-10

Applicant: MODERNATX, INC.

Inventor： SMITH, Michael, H.

IPC: A61K9/127 ,  A61K9/51

Abstract: Stabilized formulations of lipids and nucleic acids, including lipid nanoparticle formulations which encapsulate nucleic acids are disclosed herein. Methods of using the formulations are also provided.

公开(公告)号：WO2023009421A1

公开(公告)日：2023-02-02

申请号：PCT/US2022/038151

申请日：2022-07-25

Applicant: MODERNATX, INC.

Inventor： SMITH, Michael, H. ,  SOOD, Nimil ,  TIAN, Chang ,  DOHERTY, Daniel, W.

IPC: A61K9/51 ,  A61K9/00 ,  C12N15/00

Abstract: Provided are empty lipid nanoparticle compositions, and processes for their preparation, which are useful in the preparation of therapeutic or prophylactic lipid nanoparticle compositions comprising a therapeutic or prophylactic agent including, for example, nucleic acids such as mRNA.

公开(公告)号：WO2023283642A2

公开(公告)日：2023-01-12

申请号：PCT/US2022/073564

申请日：2022-07-08

Applicant: MODERNATX, INC.

Inventor： STEWART-JONES, Guillaume

IPC: A61K39/215 ,  C07H21/02 ,  A61K39/12 ,  A61P31/14 ,  A61K9/5123 ,  C07K14/005 ,  C12N15/88 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The disclosure relates to pan-human coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：WO2022266012A1

公开(公告)日：2022-12-22

申请号：PCT/US2022/033300

申请日：2022-06-13

Applicant: MODERNATX, INC.

Inventor： STEWART-JONES, Guillaume

IPC: C12N15/88 ,  C12N7/00 ,  A61K47/14 ,  A61K47/18 ,  A61K47/24 ,  A61K47/28 ,  A61K39/00 ,  A61K39/215 ,  A61K9/00 ,  A61K9/127 ,  A61P31/14 ,  C07K14/005

Abstract: The disclosure provides SARS-CoV-2 mRNA vaccines, comprising a double proline mutation at positions K986 and V987, and an additional substitution D428N that introduces an N-glycosylation site, as well as methods of using the vaccines and compositions comprising the vaccines.

公开(公告)号：WO2022226318A1

公开(公告)日：2022-10-27

申请号：PCT/US2022/025967

申请日：2022-04-22

Applicant: MODERNATX, INC. ,  COX, James, C.

Inventor： BRADER, Mark ,  BANKS, Jessica ,  GYAWALI, Dipendra ,  KLOCZEWIAK, Marek

IPC: A61K9/51 ,  A61K9/00

Abstract: Stabilized formulations of lipids and nucleic acids, including lipid nanoparticle formulations which encapsulate nucleic acids. Methods of making and of use of the formulations stabilized, by chemical compounds are also provided.