公开(公告)号：WO2023084013A1

公开(公告)日：2023-05-19

申请号：PCT/EP2022/081592

申请日：2022-11-11

Applicant: MODERNATX, INC.

Inventor： GAN, Li-Ming ,  ROSENMEIER, Jaya Birgitte

IPC: A61K31/7115 ,  A61K38/18 ,  A61P9/04 ,  A61P9/10 ,  A61P9/00

Abstract: This disclosure relates to compositions comprising modified RNA encoding VEGF-A, and the use of such compositions in methods of treating patients suffering from dilated cardiomyopathy and heart failure associated with dilated cardiomyopathy.

公开(公告)号：WO2023061985A2

公开(公告)日：2023-04-20

申请号：PCT/EP2022/078199

申请日：2022-10-11

Applicant: MODERNATX, INC.

Inventor： GAN, Li-Ming

IPC: C12N15/19 ,  A61K31/7088

Abstract: This disclosure relates to compositions comprising modified RNA encoding VEGF-A, and the use of such compositions in methods of treating patients suffering from heart diseases responsive to VEGF-A therapy. Further aspects of the disclosure relate to use of such compositions in methods of improving LVEF, methods of improving the quality of life of patients, and methods of improving ventricular wall motion in patients suffering from heart diseases responsive to VEGF-A therapy.