-
公开(公告)号：WO2006120697A2
公开(公告)日：2006-11-16
申请号：PCT/IN2006/000057
申请日：2006-02-20
Applicant: PHARMED MEDICARE PRIVATE LIMITED , RATNAM, Rakesh , MOFIZUDDIN, Mohammed , AURORA, Sundeep
Inventor： RATNAM, Rakesh , MOFIZUDDIN, Mohammed , AURORA, Sundeep
IPC: G02B26/00
Abstract: A method is disclosed for regioselective synthesis of sucrose-6-acetate via formation of a novel sucrose-tin adduct using sucrose and DBTO. The novel tin adduct can be represented by a formula (6-O-sucrose) - O - Snbutyl.sub.2 -O- (6-O-sucrose) or as 1,3.( di O-sucrose) dibutyl stannylene. The adduct is acylated to yield sucrose-6-acetate or sucrose-6-benzoate as major product.
Abstract translation: 公开了通过使用蔗糖和DBTO形成新的蔗糖 - 锡加合物来区域选择性合成蔗糖-6-乙酸酯的方法。 新型锡加合物可以由式（6-O-蔗糖）-O-锡丁基-O-O-（6-O-蔗糖）或1,3-二（二O-蔗糖）二丁基亚锡代表。 将加合物酰化生成蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯作为主要产物。
-
2.发明申请GENERATION OF PHOSPHORUS OXYCHLORIDE AS BY-PRODUCT FROM PHOSPHORUS PENTACHLORIDE AND DMF AND ITS USE FOR CHLORINATION REACTION BY CONVERTING INTO VILSMEIER-HAACK REAGENT. 审中-公开从磷酸二氢钾和DMF中产生磷酰氯作为副产物，并通过转化为灭火剂试剂将其用于氯化反应。
公开(公告)号：WO2007017891A3
公开(公告)日：2009-04-09
申请号：PCT/IN2006000151
申请日：2006-04-28
Applicant: PHARMED MEDICARE PVT LTD , RATNAM RAKESH , SUNDEEP AURORA , MOFIZUDDIN MOHAMMED
Inventor： RATNAM RAKESH , SUNDEEP AURORA , MOFIZUDDIN MOHAMMED
CPC classification number: C01B25/10 , C07B39/00 , C07C249/02 , C07F9/1403 , C07H1/00 , C07H5/02 , C07H13/04 , C07H13/08 , C07C251/04
Abstract: A process is described wherein after formation of first crop of Vilsmeier-Haack reagent by reacting Phosphorus Pentachloride with N,N-dimethylformamide to form a first crop of Vilsmeier reagent as insoluble crystals, a by-product of this reaction, the Phosphorus Oxy-Chloride, reacts with N,N-dimethylformamide to give a second crop of Vilsmeier reagent. This second crop of Vilsmeier reagent is soluble in DIV1F. This process makes it possible to double the yield of chlorinated substrate, such as sucrose-6-acetate or sucrose-6-benzoate, from the same quantity of Phosphorus Pentachloride.
Abstract translation: 描述了一种方法，其中在通过使五氯化磷与N，N-二甲基甲酰胺反应形成第一批Vilsmeier-Haack试剂后，形成第一批Vilsmeier试剂作为不溶性晶体，该反应的副产物是氧氯化磷 与N，N-二甲基甲酰胺反应，得到第二批Vilsmeier试剂。 第二批Vilsmeier试剂可溶于DIV1F。 该方法可以使来自相同量的五氯化磷的氯化底物如蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯的产率增加一倍。
-
Patent Agency Ranking3.发明申请PROCESS FOR THE PRODUCTION OF A CHLORINATING REAGENT AND ITS USE IN THE PREPARATION OF CHLORINATED SUGARS 审中-公开生产氯仿试剂的过程及其在制备氯化糖中的应用
公开(公告)号：WO2007099557B1
公开(公告)日：2008-02-07
申请号：PCT/IN2007000076
申请日：2007-02-28
Applicant: PHARMED MEDICARE PVT LTD , RATNAM RAKESH , AURORA SUNDEEP , MOFIZUDDIN MOHAMMED
Inventor： RATNAM RAKESH , AURORA SUNDEEP , MOFIZUDDIN MOHAMMED
Abstract: A process for controlling the emission of gaseous by-products in the preparation of a Vilsmeier reagent, and its use as a chlorinating reagent in the production of high intensity sweeteners, such as trichlorogalactosucrose, from partially protected sugars. The process comprises reacting a sulfur containing inorganic acid, such as thionyl chloride or sulfuryl chloride with a tertiary amide in the presence of an inert solid powder or reverse addition of the reagents; the produced Vilsmeier reagent can be used in-situ or in an isolated form.
Abstract translation: 用于控制Vilsmeier试剂制备中气态副产物排放的方法，以及其在部分保护的糖生产高强度甜味剂如三氯半乳糖中作为氯化试剂的用途。 该方法包括在惰性固体粉末存在下使含硫无机酸如亚硫酰氯或磺酰氯与叔酰胺反应或反向加入; 所生产的Vilsmeier试剂可以原位或分离形式使用。
-
4.发明申请PROCESS FOR THE PRODUCTION OF A CHLORINATING REAGENT AND ITS USE IN THE PREPARATION OF CHLORINATED SUGARS 审中-公开生产氯仿试剂的过程及其在制备氯化糖中的应用
公开(公告)号：WO2007099557A3
公开(公告)日：2007-12-06
申请号：PCT/IN2007000076
申请日：2007-02-28
Applicant: PHARMED MEDICARE PVT LTD , RATNAM RAKESH , AURORA SUNDEEP , MOFIZUDDIN MOHAMMED
Inventor： RATNAM RAKESH , AURORA SUNDEEP , MOFIZUDDIN MOHAMMED
Abstract: A process for controlling the emission of gaseous by-products in the preparation of a Vilsmeier reagent, and its use as a chlorinating reagent in the production of high intensity sweeteners, such as trichlorogalactosucrose, from partially protected sugars. The process comprises reacting a sulfur containing inorganic acid, such as thionyl chloride or sulfuryl chloride with a tertiary amide in the presence of an inert solid powder or reverse addition of the reagents; the produced Vilsmeier reagent can be used in-situ or in an isolated form.
Abstract translation: 用于控制Vilsmeier试剂制备中气态副产物排放的方法，以及其在部分保护的糖生产高强度甜味剂如三氯半乳糖中作为氯化试剂的用途。 该方法包括在惰性固体粉末存在下使含硫无机酸如亚硫酰氯或磺酰氯与叔酰胺反应或反向加入; 所生产的Vilsmeier试剂可以原位或分离形式使用。
-
公开(公告)号：WO2006120697A3
公开(公告)日：2007-03-29
申请号：PCT/IN2006000057
申请日：2006-02-20
Applicant: PHARMED MEDICARE PVT LTD , RATNAM RAKESH , MOFIZUDDIN MOHAMMED , AURORA SUNDEEP
Inventor： RATNAM RAKESH , MOFIZUDDIN MOHAMMED , AURORA SUNDEEP
Abstract: A method is disclosed for regioselective synthesis of sucrose-6-acetate via formation of a novel sucrose-tin adduct using sucrose and DBTO. The novel tin adduct can be represented by a formula (6-O-sucrose) - O - Snbutyl.sub.2 -O- (6-O-sucrose) or as 1,3.( di O-sucrose) dibutyl stannylene. The adduct is acylated to yield sucrose-6-acetate or sucrose-6-benzoate as major product.
Abstract translation: 公开了通过使用蔗糖和DBTO形成新的蔗糖 - 锡加合物来区域选择性合成蔗糖-6-乙酸酯的方法。 新型锡加合物可以由式（6-O-蔗糖）-O-锡丁基-O-O-（6-O-蔗糖）或1,3-二（二O-蔗糖）二丁基亚锡代表。 将加合物酰化生成蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯作为主要产物。
-
6.发明申请A NOVEL CHLORINATION REAGENT AND A NOVEL PROCESS FOR CHLORINATION OF SUGARS USING THIONYL CHLORIDE 审中-公开一种新的氯化试剂和一种使用氯化亚砷酸溶液的新工艺
公开(公告)号：WO2007099557A2
公开(公告)日：2007-09-07
申请号：PCT/IN2007/000076
申请日：2007-02-28
Applicant: PHARMED MEDICARE PVT. LTD. , RATNAM, Rakesh , AURORA, Sundeep , MOFIZUDDIN, Mohammed
Inventor： RATNAM, Rakesh , AURORA, Sundeep , MOFIZUDDIN, Mohammed
Abstract: Preparation of chlorinating reagent or chlorination reaction itself for use in a reaction such as production of high intensity sweetener trichlorogalactosucrose (TGS) from partially protected sucrose comprising reaction of dimethylformamide (DMF) with thionyl chloride or another sulphur containing inorganic acid chlorides including sulphuryl chloride is faced with a problem of prolific release of gaseous by-products, that at times may lead to violent explosion also. This problem is solved by innovative addition of solid powder inert to the constituents of the chlorination reaction mixture to the reaction, or by adding DMF to acid chloride solution in that order. The invention also leads to use of isolated solid Vilsmeier reagent being used for chlorination in a solvent other than DMF making it possible to avoid altogether problems arising from use of DMF which include irrecoverable loss in alkaline as well as acid conditions, interference in crystallization of TGS and the like.
Abstract translation: 制备氯化试剂或氯化反应本身用于反应，例如从部分保护的蔗糖生产高强度甜味剂三氯半乳蔗糖（TGS），包括二甲基甲酰胺（DMF）与亚硫酰氯或另一种含硫的无机酰氯（包括磺酰氯）的反应 存在气态副产物多产释放的问题，有时也可能导致剧烈的爆炸。 通过将氯化反应混合物的成分惰性的固体粉末添加到反应中，或者通过向该酰氯溶液中依次加入DMF来解决这个问题。 本发明还导致使用分离的固体维尔斯迈尔试剂用于在DMF以外的溶剂中进行氯化，使得可以避免使用DMF引起的一切问题，其包括在碱性和酸性条件下不可恢复的损失，TGS的结晶干扰 等等。
-
7.发明申请GENERATION OF PHOSPHORUS OXYCHLORIDE AS BY-PRODUCT FROM PHOSPHORUS PENTACHLORIDE AND DMF AND ITS USE FOR CHLORINATION REACTION BY CONVERTING INTO VILSMEIER-HAACK REAGENT. 审中-公开从磷酸二氢钾和DMF中产生磷酰氯作为副产物，并通过转化为灭火剂试剂将其用于氯化反应。
公开(公告)号：WO2007017891A2
公开(公告)日：2007-02-15
申请号：PCT/IN2006/000151
申请日：2006-04-28
Applicant: PHARMED MEDICARE PRIVATE LIMITED , RATNAM, Rakesh , SUNDEEP, Aurora , MOFIZUDDIN, Mohammed
Inventor： RATNAM, Rakesh , SUNDEEP, Aurora , MOFIZUDDIN, Mohammed
CPC classification number: C01B25/10 , C07B39/00 , C07C249/02 , C07F9/1403 , C07H1/00 , C07H5/02 , C07H13/04 , C07H13/08 , C07C251/04
Abstract: A process is described wherein after formation of first crop of Vilsmeier-Haack reagent by reacting Phosphorus Pentachloride with N,N-dimethylformamide to form a first crop of Vilsmeier reagent as insoluble crystals, a by-product of this reaction, the Phosphorus Oxy-Chloride, reacts with N,N-dimethylformamide to give a second crop of Vilsmeier reagent. This second crop of Vilsmeier reagent is soluble in DIV1F. This process makes it possible to double the yield of chlorinated substrate, such as sucrose-6-acetate or sucrose-6-benzoate, from the same quantity of Phosphorus Pentachloride.
Abstract translation: 描述了一种方法，其中在通过使五氯化磷与N，N-二甲基甲酰胺反应形成第一批Vilsmeier-Haack试剂后，形成第一批Vilsmeier试剂作为不溶性晶体，该反应的副产物是氧氯化磷 与N，N-二甲基甲酰胺反应，得到第二批Vilsmeier试剂。 第二批Vilsmeier试剂可溶于DIV1F。 该方法可以使来自相同量的五氯化磷的氯化底物如蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯的产率增加一倍。
-
-
-
-
-
-
Search Results
7
records
(took 0.007 seconds)
