公开(公告)号：WO1988008844A1

公开(公告)日：1988-11-17

申请号：PCT/EP1988000341

申请日：1988-04-22

申请人： EPROVA AG ,  MUELLER, Hans, Rudolf ,  ULMANN, Martin ,  CONTI, Josef ,  MUERDEL, Günter

发明人： EPROVA AG

IPC分类号： C07D475/04

CPC分类号： C07D475/04

摘要： A process makes possible the production of (6S) folinic acids and their salts by recrystallization of alkaline earth salts of (6R, S) folinic acids, possibly by release of these acids contained in alkaline earth folinates and/or possibly their conversion to alkali salts by at least one recrystallization in the presence of a base. The invention also concerns the (6S) folinates of calcium, magnesium, potassium and sodium and the (6S) folinic acids produced by the process described.

摘要翻译： 一种方法可以通过（6R，S）亚叶酸的碱土金属盐的重结晶，可能通过释放碱土金属叶酸中所含的这些酸和/或可能转化成碱式盐来生产（6S）亚叶酸及其盐 通过在碱存在下至少一次重结晶。 本发明还涉及通过所述方法产生的钙，镁，钾和钠的（6S）叶酸和（6S）亚叶酸。

公开(公告)号：WO02066142A3

公开(公告)日：2002-10-10

申请号：PCT/EP0115124

申请日：2001-12-20

申请人： SEFAR AG ,  MUELLER HANS RUDOLF ,  MAURER CHRISTOPH

发明人： MUELLER HANS RUDOLF ,  MAURER CHRISTOPH

IPC分类号： B01D39/08 ,  B01D39/16

CPC分类号： B01D39/083 ,  B01D39/1623 ,  B01D2239/0208 ,  B01D2239/0216 ,  B01D2239/0478 ,  B01D2239/1291 ,  Y10T442/20 ,  Y10T442/60 ,  Y10T442/601 ,  Y10T442/605 ,  Y10T442/607 ,  Y10T442/637

摘要： The invention relates to a filter cloth for a filter, provided with a supporting surface, a fixing area for attachment to the filter and a filtration area which is borne on the supporting surface. An extensible fabric structure is provided at least in the filtration area in order to raise said filtration area from the supporting surface.Highly elastic monofilament threads are selectively incorporated into the fabric structure, at least in said filtration area, in order to produce a defined amount of elasticity.

摘要翻译： 所述Erfingdung涉及一种滤布用于具有带Befestigengsbereich的支撑表面用于连接到过滤器和用于搁置在所述支撑表面上的过滤面积的过滤器。 为了便于吊起支撑面的过滤面积。 为了便于吊起支撑面的过滤面积。 用于提升在过滤区域中设置至少一个debnbare组织结构中的支撑表面的过滤面积，被并入Erzeugeng限定的弹性至少在目标高弹性单丝纱线在织物结构中的过滤面积。

公开(公告)号：WO0200659A3

公开(公告)日：2002-03-21

申请号：PCT/US0140908

申请日：2001-06-08

申请人： NEOTHERAPEUTICS INC ,  GLASKY ALVIN ,  BOLLINGER HEINRICH ,  MUELLER HANS RUDOLF

发明人： GLASKY ALVIN ,  BOLLINGER HEINRICH ,  MUELLER HANS RUDOLF

IPC分类号： A61P25/28 ,  C07D233/88 ,  C07D233/90 ,  C07D473/30 ,  A61K31/522

CPC分类号： C07D233/90 ,  C07D473/30

摘要： An improved method of systhesis of a 9-substituted hypoxanthine derivative comprises the steps of: (1) reacting aminocyanacetamide with triethyl orthoformate to form an imidoester derivative of aminocyanacetamide; (2) forming a compound having a reactive amino group on a hydrocarbyl moiety, the hydrocarbyl moiety being linked through an amide group to a physiologically active moiety or an esterified derivative of a physiologically active moiety including therein an esterified benzoyl group; (3) reacting the imidoester with the compound having the reactive amino group on the hydrocarbyl moiety to form a derivative of 5-aminoimidazole-4-carboxamide substituted at the 1-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; (4) forming the six-membered heterocyclic ring of the purine moiety of the hypoxanthine by reacting the derivative of 5-aminoimidazole-4-carboxamide formed in step (3) with triethyl orthoformate to form a 9-substituted hypoxanthine compound substituted at the 9-position with a hydrocarbyl moiety linked through an amide group to a physiologically active moiety including therein an optionally esterified benzoyl group; and (5) hydrolyzing the ester of the optionally esterified group if present.

摘要翻译： 9-取代的次黄嘌呤衍生物的合成改进方法包括以下步骤：（1）使氨基异氰酸乙酰胺与原甲酸三乙酯反应形成氨基异丁酰胺的酰亚胺酯衍生物; （2）在烃基部分上形成具有反应性氨基的化合物，烃基部分通过酰胺基与生理活性部分或其生物活性部分的酯化衍生物连接，其中包括酯化苯甲酰基; （3）使亚氨酯与在烃基部分上具有反应性氨基的化合物反应，以形成在1-位被取代的5-氨基咪唑-4-甲酰胺的衍生物，其中烃基部分通过酰胺基连接到生理活性部分 其中包括任选酯化的苯甲酰基; （4）通过使步骤（3）中形成的5-氨基咪唑-4-甲酰胺的衍生物与原甲酸三乙酯反应形成在9位被取代的9-取代的次黄嘌呤化合物，形成次黄嘌呤嘌呤部分的六元杂环 - 具有通过酰胺基团连接到生理活性部分的烃基部分，其中包括任选酯化的苯甲酰基; 和（5）水解任选酯化基团的酯（如果存在）。