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公开(公告)号：WO2008024319A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/018437
申请日：2007-08-20
Applicant: CODON DEVICES, INC. , MUIR, Craig, Douglas , EMIG, Christopher, J.
Inventor： MUIR, Craig, Douglas , EMIG, Christopher, J.
CPC classification number: B01L3/5027 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00722 , B01J2219/00912 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0838 , B01L2400/0421 , B01L2400/0487
Abstract: Certain aspects of the present invention provide devices and methods for assembling nucleic acid molecules on micro fluidic devices. Aspects of the invention provide microfluidic substrates and devices for assembling nucleic acids via extension and/or ligation reactions. The invention also provides systems comprising one or more acoustic liquid handlers, one or more microfluidic devices, and/or one or more robotic liquid handlers for automating a nucleic acid assembly procedure.
Abstract translation: 本发明的某些方面提供了用于在微流体装置上组装核酸分子的装置和方法。 本发明的方面提供用于通过延伸和/或连接反应装配核酸的微流体底物和装置。 本发明还提供了包括一个或多个声学液体处理器，一个或多个微流体装置和/或一个或多个用于使核酸组装过程自动化的机器人液体处理器的系统。
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公开(公告)号：WO2008024319A3
公开(公告)日：2008-04-10
申请号：PCT/US2007018437
申请日：2007-08-20
Applicant: CODON DEVICES INC , MUIR CRAIG DOUGLAS , EMIG CHRISTOPHER J
Inventor： MUIR CRAIG DOUGLAS , EMIG CHRISTOPHER J
CPC classification number: B01L3/5027 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00722 , B01J2219/00912 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0838 , B01L2400/0421 , B01L2400/0487
Abstract: Certain aspects of the present invention provide devices and methods for assembling nucleic acid molecules on micro fluidic devices, e.g. via extension and/or ligation reactions. The invention also provides systems comprising one or more acoustic liquid handlers, one or more microfluidic devices, and/or one or more robotic liquid handlers for automating a nucleic acid assembly- procedure. The microdevice may comprise the following components: a sipper, or means for transferring reagents (310); a main channel (315); a splitter, or means for transferring reagents (320), sample wells for storage of reagents or buffers (330, 335, 340), separation or concentration channels (350, 355) and sample or reaction wells (360, 365) e.g. a thermocycler.
Abstract translation: 本发明的某些方面提供了用于在微流体装置上装配核酸分子的装置和方法，例如， 通过延伸和/或连接反应。 本发明还提供包括一个或多个声学液体处理器，一个或多个微流体装置和/或用于使核酸组装过程自动化的一个或多个机器人液体处理器的系统。 微型装置可以包括以下部件：吸嘴或用于转移试剂的装置（310）; 主渠道（315）; 分离器或用于转移试剂（320）的装置，用于储存试剂或缓冲液（330,335,340），分离或浓缩通道（350,355）和样品或反应孔（360,365）的样品孔。 一个热循环仪
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公开(公告)号：WO2008024319A8
公开(公告)日：2008-05-29
申请号：PCT/US2007018437
申请日：2007-08-20
Applicant: CODON DEVICES INC , MUIR CRAIG DOUGLAS , EMIG CHRISTOPHER J
Inventor： MUIR CRAIG DOUGLAS , EMIG CHRISTOPHER J
CPC classification number: B01L3/5027 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00423 , B01J2219/00585 , B01J2219/0059 , B01J2219/00722 , B01J2219/00912 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0816 , B01L2300/0838 , B01L2400/0421 , B01L2400/0487
Abstract: Certain aspects of the present invention provide devices and methods for assembling nucleic acid molecules on micro fluidic devices, e.g. via extension and/or ligation reactions. The invention also provides systems comprising one or more acoustic liquid handlers, one or more microfluidic devices, and/or one or more robotic liquid handlers for automating a nucleic acid assembly procedure. The microdevice may comprise the following components: a sipper, or means for transferring reagents (310); a main channel (315); a spitter, or means for transferring reagents (320), sample wells for storage of reagents or buffers (330, 335, 340), separation or concentration channels (350, 355) and sample or reaction wells (360, 365) e.g. a thermocycler.
Abstract translation: 本发明的某些方面提供了用于在微流体装置上装配核酸分子的装置和方法，例如， 通过延伸和/或连接反应。 本发明还提供了包括一个或多个声学液体处理器，一个或多个微流体装置和/或一个或多个用于使核酸组装过程自动化的机器人液体处理器的系统。 微型装置可以包括以下部件：吸嘴或用于转移试剂的装置（310）; 主渠道（315）; 用于转移试剂（320）的样品池，用于储存试剂或缓冲液（330,335,340），分离或浓缩通道（350,355）和样品或反应孔（360,365）的样品孔。 一个热循环仪
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