公开(公告)号：WO2010089340A3

公开(公告)日：2010-12-09

申请号：PCT/EP2010051341

申请日：2010-02-04

Applicant: INTERCELL AG ,  NAGY ESZTER ,  SENN BEATRICE ,  HANNER MARKUS ,  BERGER MANFRED ,  MEINKE ANDREAS ,  VON GABAIN ALEXANDER ,  MURRAY BARBARA ,  SINGH KAVINDRA V

Inventor： NAGY ESZTER ,  SENN BEATRICE ,  HANNER MARKUS ,  BERGER MANFRED ,  MEINKE ANDREAS ,  VON GABAIN ALEXANDER ,  MURRAY BARBARA ,  SINGH KAVINDRA V

IPC: C07K14/315 ,  C07K16/12 ,  G01N33/569

CPC classification number: C07K14/335 ,  A61K39/012 ,  A61K2039/55566 ,  C07K16/1267 ,  G01N33/56916

Abstract: The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

Abstract translation: 本发明涉及粪肠球菌（粪肠球菌）的保护性肽或其功能活性变体，任选进一步由额外的氨基酸残基组成; 编码它的核酸; 包含所述肽或所述核酸的药物组合物; 特异性结合抗原的抗体或其功能活性片段; 产生所述抗体的杂交瘤细胞系; 生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制造用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断粪肠球菌感染的方法; 以及所述肽用于肽的相互作用配偶体的分离和/或纯化和/或鉴定的用途。

公开(公告)号：WO2010089340A2

公开(公告)日：2010-08-12

申请号：PCT/EP2010/051341

申请日：2010-02-04

Applicant: INTERCELL AG ,  NAGY, Eszter ,  SENN, Beatrice ,  HANNER, Markus ,  BERGER, Manfred ,  MEINKE, Andreas ,  VON GABAIN, Alexander ,  MURRAY, Barbara ,  SINGH, Kavindra V.

Inventor： NAGY, Eszter ,  SENN, Beatrice ,  HANNER, Markus ,  BERGER, Manfred ,  MEINKE, Andreas ,  VON GABAIN, Alexander ,  MURRAY, Barbara ,  SINGH, Kavindra V.

IPC: C07K14/315 ,  C07K16/12 ,  G01N33/569

CPC classification number: C07K14/335 ,  A61K39/012 ,  A61K2039/55566 ,  C07K16/1267 ,  G01N33/56916

Abstract: The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

Abstract translation: 本发明涉及粪肠球菌（粪肠球菌）或其功能性活性变体的保护性肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 一种诊断粪肠球菌感染的方法; 以及所述肽用于分离和/或纯化和/或鉴定肽的相互作用配偶体的用途。