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    BIOMARKERS FOR RHEUMATOID ARTHRITIS AND USAGE THEREOF
    2.
    发明申请
    BIOMARKERS FOR RHEUMATOID ARTHRITIS AND USAGE THEREOF 审中-公开
    生物标记物用于湿疹病毒及其使用

    公开(公告)号：WO2016050111A1

    公开(公告)日：2016-04-07

    申请号：PCT/CN2015/083490

    申请日：2015-07-07

    申请人： BGI SHENZHEN

    发明人： FENG, Qiang ,  ZHANG, Dongya ,  JIA, Huijue ,  WANG, Donghui ,  WANG, Jun

    IPC分类号： C12N1/20 ,  C12N1/04 ,  C12Q1/68

    CPC分类号： C12Q1/689 ,  A61K35/747 ,  C07K14/335 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： Biomarkers for rheumatoid arthritis (RA) are described. RA-associated metagenomic linkage groups (MLGs) have been identified and validated in gut and oral microbiotas. These MLGs are used in systems, methods and products for identifying a subject suffering from RA or having risk of developing RA, monitoring the efficacy of an RA treatment in a subject, or selecting or modifying a treatment for an RA patient.

    摘要翻译： 描述了类风湿关节炎（RA）的生物标志物。 已经在肠道和口腔微生物群体中鉴定和验证了RA相关的巨基因组连锁群（MLG）。 这些MLG用于识别患有RA的患者或具有发展RA的风险的系统，方法和产品，监测受试者中RA治疗的功效，或选择或修改RA患者的治疗。

    PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO
    6.
    发明申请
    PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO 审中-公开
    肽对E.Facalis有保护作用，方法和与其相关的用途

    公开(公告)号：WO2010089340A3

    公开(公告)日：2010-12-09

    申请号：PCT/EP2010051341

    申请日：2010-02-04

    申请人： INTERCELL AG ,  NAGY ESZTER ,  SENN BEATRICE ,  HANNER MARKUS ,  BERGER MANFRED ,  MEINKE ANDREAS ,  VON GABAIN ALEXANDER ,  MURRAY BARBARA ,  SINGH KAVINDRA V

    发明人： NAGY ESZTER ,  SENN BEATRICE ,  HANNER MARKUS ,  BERGER MANFRED ,  MEINKE ANDREAS ,  VON GABAIN ALEXANDER ,  MURRAY BARBARA ,  SINGH KAVINDRA V

    IPC分类号： C07K14/315 ,  C07K16/12 ,  G01N33/569

    CPC分类号： C07K14/335 ,  A61K39/012 ,  A61K2039/55566 ,  C07K16/1267 ,  G01N33/56916

    摘要： The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

    摘要翻译： 本发明涉及粪肠球菌（粪肠球菌）的保护性肽或其功能活性变体，任选进一步由额外的氨基酸残基组成; 编码它的核酸; 包含所述肽或所述核酸的药物组合物; 特异性结合抗原的抗体或其功能活性片段; 产生所述抗体的杂交瘤细胞系; 生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制造用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 诊断粪肠球菌感染的方法; 以及所述肽用于肽的相互作用配偶体的分离和/或纯化和/或鉴定的用途。

    PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO
    7.
    发明申请
    PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO 审中-公开
    抗生素的保护作用与其相关的E. FAECALIS，方法和用途

    公开(公告)号：WO2010089340A2

    公开(公告)日：2010-08-12

    申请号：PCT/EP2010/051341

    申请日：2010-02-04

    申请人： INTERCELL AG ,  NAGY, Eszter ,  SENN, Beatrice ,  HANNER, Markus ,  BERGER, Manfred ,  MEINKE, Andreas ,  VON GABAIN, Alexander ,  MURRAY, Barbara ,  SINGH, Kavindra V.

    发明人： NAGY, Eszter ,  SENN, Beatrice ,  HANNER, Markus ,  BERGER, Manfred ,  MEINKE, Andreas ,  VON GABAIN, Alexander ,  MURRAY, Barbara ,  SINGH, Kavindra V.

    IPC分类号： C07K14/315 ,  C07K16/12 ,  G01N33/569

    CPC分类号： C07K14/335 ,  A61K39/012 ,  A61K2039/55566 ,  C07K16/1267 ,  G01N33/56916

    摘要： The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.

    摘要翻译： 本发明涉及粪肠球菌（粪肠球菌）或其功能性活性变体的保护性肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 一种诊断粪肠球菌感染的方法; 以及所述肽用于分离和/或纯化和/或鉴定肽的相互作用配偶体的用途。

    LACTIC ACID BACTERIA ISOLATED FROM MOTHER'S MILK WITH PROBIOTIC ACTIVITY AND INHIBITORY ACTIVITY AGAINST BODY WEIGHT AUGMENTATION
    10.
    发明申请
    LACTIC ACID BACTERIA ISOLATED FROM MOTHER'S MILK WITH PROBIOTIC ACTIVITY AND INHIBITORY ACTIVITY AGAINST BODY WEIGHT AUGMENTATION 审中-公开
    从母乳中分离的乳酸菌具有抗生素活性和抑制体重反应的活性

    公开(公告)号：WO2008016214A1

    公开(公告)日：2008-02-07

    申请号：PCT/KR2007/002363

    申请日：2007-05-14

    申请人： BIONEER CORPORATION ,  KANG, Ji Hee ,  YOU, Byeung Il ,  YUN, Sung Il ,  PARK, Han Oh

    发明人： KANG, Ji Hee ,  YOU, Byeung Il ,  YUN, Sung Il ,  PARK, Han Oh

    IPC分类号： C12N1/20

    CPC分类号： C12R1/225 ,  A23C9/1234 ,  A23L33/135 ,  A23L33/18 ,  A23Y2220/37 ,  A61K38/00 ,  C07K14/335 ,  C12N1/20

    摘要： The present invention relates to a lactic acid bacterium isolated from human mother's milk, more precisely a Lactobacillus gasseri BNR17 strain that is isolated from Korean mother's milk and has excellent probiotic activity including acid resistance, bile acid resistance and antimicrobial activity and weight gaining inhibitory effect as well. Again, the Lactobacillus gasseri BNR17 of the present invention has excellent acid resistance, bile acid resistance, enteric absorption activity and antimicrobial activity against pathogenic microorganisms, in addition to the weight gaining inhibitory effect by synthesizing indigestible polysaccharides from monosaccharides included in food taken and releasing the synthesized polysaccharides out of the body. Therefore, the strain of the invention, owing to such beneficiary effects, can be effectively used not only for the production of fermented milk, other fermented food products and animal feeds but also for the production of live cell products and food additives for preventing weight gaining.

    摘要翻译： 本发明涉及从人母乳分离的乳酸菌，更准确地说是从韩国母乳中分离的加氏乳杆菌BNR17菌株，具有优异的益生菌活性，包括耐酸性，胆汁酸耐性和抗微生物活性以及增重抑制作用 好。 此外，本发明的加氏乳杆菌BNR17除了通过从包含在食物中的单糖合成难消化的多糖而获得的重量增加抑制作用之外，还具有优异的耐酸性，耐胆汁酸性，肠吸收活性和抗病原微生物的抗微生物活性， 合成多糖出体外。 因此，由于这种受益效应，本发明的菌株不仅可以有效地用于生产发酵乳，其他发酵食品和动物饲料，而且可用于生产活细胞产品和食品添加剂，以防止体重增加 。