中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

35 records (took 0.02 seconds)

    MONOCLONAL ANTIBODY PAM4 AND ITS USE FOR DIAGNOSIS AND THERAPY OF PANCREATIC CANCER
    4.
    发明申请
    MONOCLONAL ANTIBODY PAM4 AND ITS USE FOR DIAGNOSIS AND THERAPY OF PANCREATIC CANCER 审中-公开
    单克隆抗体PAM4及其用于诊断和治疗胰腺癌的用途

    公开(公告)号：WO2003106497A1

    公开(公告)日：2003-12-24

    申请号：PCT/GB2003/002585

    申请日：2003-06-16

    Applicant: IMMUNOMEDICS, INC. ,  MCCALL, John, Douglas ,  GOLD, David, V. ,  GOLDENBERG, David, M. ,  HANSEN, Hans

    Inventor： GOLD, David, V. ,  GOLDENBERG, David, M. ,  HANSEN, Hans

    IPC: C07K16/18

    CPC classification number: C07K16/44 ,  A61K51/1057 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/54 ,  C07K2317/565

    Abstract: This invention relates to monovalent and multivalent, monospecific antibodies and to monovalent and multivalent, multispecific antibodies. One embodiment of these antibodies has one or more identical binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these antibodies has two or more binding sites where these binding sites have affinity towards different epitopes on a target antigen or different target antigens, or have affinity towards a target antigen and a hapten. The present invention further relates to recombinant vectors useful for the expression of these functionalantibodies in a host. More specifically, the present invention relates to the tumor-­associated antibody designated PAM4. The invention further relates to chimeric PAM4 antibodies, and the use of such antibodies in diagnosis and therapy.

    Abstract translation: 本发明涉及单价和多价单特异性抗体以及单价和多价多特异性抗体。 这些抗体的一个实施方案具有一个或多个相同的结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些抗体的另一个实施方案具有两个或多个结合位点，其中这些结合位点对靶抗原或不同靶抗原上的不同表位具有亲和力，或对靶抗原和半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性抗体的重组载体。 更具体地，本发明涉及称为PAM4的肿瘤相关抗体。 本发明还涉及嵌合PAM4抗体，以及这些抗体在诊断和治疗中的用途。

    NEUTROPHIL IMAGING METHODS IN CYCTIC FIBROSIS
    5.
    发明申请
    NEUTROPHIL IMAGING METHODS IN CYCTIC FIBROSIS 审中-公开

    公开(公告)号：WO2003103723A3

    公开(公告)日：2003-12-18

    申请号：PCT/GB2003/002392

    申请日：2003-06-02

    Applicant: IMMUNOMEDICS, INC. ,  McCALL, John, Douglas ,  GOLDENBERG, David, M.

    Inventor： GOLDENBERG, David, M.

    IPC: A61K47/48

    Abstract: The present invention is directed to an improved method to detect and monitor a subject having cystic fibrosis (CF) by employing at least one anti-granulocyte/neutrophil antibody or a fragment thereof and a diagnostic agent via various imaging methods, wherein said anti-granulocyte antibody is not a murine MN-3 antibody Fab' fragment that is radiolabeled with 99m Tc. Pretargeting methods for improved imaging of granulocytes accumulated in CF are also described. It is further directed to a simple, noninvasive, and effective test that can assess neutrophil delivery to the lower airways of patients with CF and effective test that can assess neutrophil delivery to the lower airways of patients with other neutrophil-mediated lung diseases.

    METHODS AND COMPOSITIONS FOR INTRAVESICAL THERAPY OF BLADDER CANCER
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR INTRAVESICAL THERAPY OF BLADDER CANCER 审中-公开
    乳腺癌手术治疗方法与组合

    公开(公告)号：WO2003101496A1

    公开(公告)日：2003-12-11

    申请号：PCT/GB2003/002387

    申请日：2003-06-02

    Applicant: IMMUNOMEDICS, INC. ,  McCALL, John, Douglas ,  GRIFFITHS, Gary, L. ,  GOLDENBERG, David, M.

    Inventor： GRIFFITHS, Gary, L. ,  GOLDENBERG, David, M.

    IPC: A61K51/10

    CPC classification number: B82Y5/00 ,  A61K9/0034 ,  A61K47/665 ,  A61K47/6897 ,  A61K51/1084 ,  A61K51/109

    Abstract: A method for treating bladder cancer by administering via the urethra a multispecific antibody comprising at least one targeting arm that binds a bladder cancer antigen and at least one capture arm that binds a carrier conjugated to one or more therapeutic agents, allowing said multispecific antibody to localize at the site of said bladder cancer, allowing any free multispecific antibody to substantially clear from the patient; and (b) administering a therapeutically effective amount of the carrier conjugated to one or more therapeutic agents.

    Abstract translation: 一种通过经由尿道给药的多特异性抗体治疗膀胱癌的方法，所述多特异性抗体包含至少一种结合膀胱癌抗原的靶向臂和结合与一种或多种治疗剂缀合的载体的至少一种捕获臂，允许所述多特异性抗体定位 在所述膀胱癌的部位，允许任何游离的多特异性抗体从患者基本上清除; 和（b）施用治疗有效量的与一种或多种治疗剂缀合的载体。

    RS7 ANTIBODIES
    7.
    发明申请
    RS7 ANTIBODIES 审中-公开

    公开(公告)号：WO2003074566A3

    公开(公告)日：2003-09-12

    申请号：PCT/GB2003/000885

    申请日：2003-03-03

    Applicant: IMMUNOMEDICS, INC. ,  MCCALL, John, Douglas

    Inventor： GOVINDAN, Serengulam ,  QU, Zhengxing ,  HANSEN, Hans, J. ,  GOLDENBERG, David, M.

    IPC: C07K16/30

    Abstract: This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.

Patent Agency Ranking