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公开(公告)号：WO2011089250A3
公开(公告)日：2011-07-28
申请号：PCT/EP2011/050909
申请日：2011-01-24
Applicant: NOVO NORDISK HEALTH CARE AG , DEMUTH, Helle , SCHIØDT, Christine, Bruun, Schiødt , NØRSKOV-LAURITSEN, Leif , CHEN, Jianhe , THYGESEN, Peter
Inventor： DEMUTH, Helle , SCHIØDT, Christine, Bruun, Schiødt , NØRSKOV-LAURITSEN, Leif , CHEN, Jianhe , THYGESEN, Peter
Abstract: The present invention relates to growth hormone (GH) compounds having additional disulphide bridges and at least one additional single point mutation making the compounds resistant to proteolytic degradation.
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公开(公告)号：WO2008102007A1
公开(公告)日：2008-08-28
申请号：PCT/EP2008/052190
申请日：2008-02-22
Applicant: NOVO NORDISK HEALTH CARE AG , HU, Sean , ZIN, Xao , JIANHUA, Wang , CHANG, Chihchuan , NØRSKOV-LAURITSEN, Leif , SU, Jing
Inventor： HU, Sean , ZIN, Xao , JIANHUA, Wang , CHANG, Chihchuan , NØRSKOV-LAURITSEN, Leif , SU, Jing
CPC classification number: C12N9/1044
Abstract: Variants of transglutaminase from Streptoverticillium ladakanum, which variants have improved selectivity for Gln-141 of human growth hormone are provided.
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公开(公告)号：WO2012010516A1
公开(公告)日：2012-01-26
申请号：PCT/EP2011/062152
申请日：2011-07-15
Applicant: NOVO NORDISK HEALTH CARE AG , ANDERSEN, Henrik Sune , MADSEN, Kjeld , DEMUTH, Helle , SCHIØDT, Christine Bruun , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter , BEHRENS, Carsten , GULDBRANDT, Mette
Inventor： ANDERSEN, Henrik Sune , MADSEN, Kjeld , DEMUTH, Helle , SCHIØDT, Christine Bruun , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter , BEHRENS, Carsten , GULDBRANDT, Mette
CPC classification number: C07K14/61 , A61K47/554
Abstract: The present invention relates to growth hormone conjugates comprising a bile acid residue, said conjugation may occur through wt or mutant amino acid residues. The growth hormone polypeptide may be wt human growth hormone or a growth hormone variant.
Abstract translation: 本发明涉及包含胆汁酸残基的生长激素缀合物，所述缀合可以通过wt或突变体氨基酸残基进行。 生长激素多肽可以是人生长激素或生长激素变体。
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公开(公告)号：WO2009004058A3
公开(公告)日：2009-01-08
申请号：PCT/EP2008/058593
申请日：2008-07-03
Applicant: NOVO NORDISK A/S , BREINHOLT, Jens , NIELSEN, Per Franklin , CHRISTENSEN, Leif , NØRSKOV-LAURITSEN, Leif , SVENSSON, Anders
Inventor： BREINHOLT, Jens , NIELSEN, Per Franklin , CHRISTENSEN, Leif , NØRSKOV-LAURITSEN, Leif , SVENSSON, Anders
IPC: A61K31/00 , A61K38/22 , C07K14/575
Abstract: The present invention relates to prolactin analogues, which analogues have increased resistance to deamidation.
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公开(公告)号：WO2008074865A1
公开(公告)日：2008-06-26
申请号：PCT/EP2007/064329
申请日：2007-12-20
Applicant: NOVO NORDISK A/S , CHRISTENSEN, Leif , NØRSKOV-LAURITSEN, Leif , RISEGAARD, Lone , BILLESTRUP, Nils , TARABYKINA, Svetlana
Inventor： CHRISTENSEN, Leif , NØRSKOV-LAURITSEN, Leif , RISEGAARD, Lone , BILLESTRUP, Nils , TARABYKINA, Svetlana
CPC classification number: A61K38/2257 , A61K38/27 , A61K2300/00
Abstract: The patent application relates to antagonistic dimers of prolactin molecules and their use in treating cancer.
Abstract translation: 该专利申请涉及催乳素分子的拮抗二聚体及其在治疗癌症中的用途。
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Patent Agency Ranking
公开(公告)号：WO2010084173A1
公开(公告)日：2010-07-29
申请号：PCT/EP2010/050725
申请日：2010-01-22
Applicant: NOVO NORDISK HEALTH CARE AG , OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
Inventor： OLSEN, Ole Hvilsted , BREINHOLT, Jens , SCHIØDT, Christine Bruun , DEMUTH, Helle , NØRSKOV-LAURITSEN, Leif , THYGESEN, Peter
Abstract: The present invention relates to stable growth hormone (GH) compounds, which through the introduction of cysteine residues have disulphide bridges, which make the compounds resistant to proteolytic degradation.
Abstract translation: 本发明涉及通过引入半胱氨酸残基具有二硫键的稳定生长激素（GH）化合物，其使得化合物对蛋白水解降解具有抗性。
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公开(公告)号：WO2008040758A1
公开(公告)日：2008-04-10
申请号：PCT/EP2007/060501
申请日：2007-10-03
Applicant: NOVO NORDISK A/S , NØRSKOV-LAURITSEN, Leif , CHRISTENSEN, Leif
Inventor： NØRSKOV-LAURITSEN, Leif , CHRISTENSEN, Leif
IPC: C07K14/575 , C12N15/12 , C07K16/26 , A61K38/22
CPC classification number: C07K14/57554
Abstract: The present invention is concerned with peptides binding to the prolactin receptor, wherein said peptides have an improved binding via binding site 1 (BS1) to the prolactin receptor. In one embodiment, said improved binding is achieved by mutation of positions 61, 71 and 73.
Abstract translation: 本发明涉及与催乳素受体结合的肽，其中所述肽具有通过结合位点1（BS1）与催乳素受体的改善的结合。 在一个实施方案中，所述改进的结合通过位置61,71和73的突变实现。
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公开(公告)号：WO2007020291A1
公开(公告)日：2007-02-22
申请号：PCT/EP2006/065440
申请日：2006-08-18
CPC classification number: C12N9/1044
Abstract: Transglutaminase from S. mobareanse with one or more substitutions at positions Tyr-75, Tyr-302, or Asp-304.
Abstract translation: 来自S. mobareanse的转谷氨酰胺酶在Tyr-75，Tyr-302或Asp-304位置具有一个或多个取代。
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公开(公告)号：WO2007020290A1
公开(公告)日：2007-02-22
申请号：PCT/EP2006/065439
申请日：2006-08-18
Applicant: NOVO NORDISK A/S , NØRSKOV-LAURITSEN, Leif , JOHANSEN, Nils, Langeland
Inventor： NØRSKOV-LAURITSEN, Leif , JOHANSEN, Nils, Langeland
CPC classification number: C12N9/1044
Abstract: Variants of transglutaminase from S mobareanse, which variants have improved selectivity against Gln-40 og Gln-141 of human growth hormone are provided.
Abstract translation: 提供了来自S mobareanse的转谷氨酰胺酶的变体，其变体对人生长激素的Gln-40g Gln-141具有改善的选择性。
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公开(公告)号：WO2014139994A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054669
申请日：2014-03-11
Applicant: NOVO NORDISK HEALTH CARE AG , ZHAO, Xin , THYGESEN, Peter , JOHANSEN, Nils Langeland , NØRSKOV-LAURITSEN, Leif
Inventor： ZHAO, Xin , THYGESEN, Peter , JOHANSEN, Nils Langeland , NØRSKOV-LAURITSEN, Leif
CPC classification number: C07K14/61 , A61K38/00 , C07K2319/30
Abstract: The invention relates to growth hormone compounds with a long plasma half-life obtained by Fc linkage. An increased half-life is an advantage allowing a less frequent or low dosage administration of therapeutic. The invention further relates to methods of producing such compound including expression vectors for heterologous expression.
Abstract translation: 本发明涉及通过Fc连锁获得的长血浆半衰期的生长激素化合物。 增加的半衰期是允许治疗剂的较少频率或低剂量给药的优点。 本发明还涉及生产包含用于异源表达的表达载体的这种化合物的方法。
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