公开(公告)号：WO2022020734A1

公开(公告)日：2022-01-27

申请号：PCT/US2021/043003

申请日：2021-07-23

Applicant: A.D. INTEGRITY APPLICATIONS LTD. ,  GAL, Avner ,  RAYKHMAN, Alexander, M. ,  NAIDIS, Eugene ,  MAYZEL, Yulia ,  KLIONSKY, Alexander ,  DIBER, Anatoly

Inventor： GAL, Avner ,  RAYKHMAN, Alexander, M. ,  NAIDIS, Eugene ,  MAYZEL, Yulia ,  KLIONSKY, Alexander ,  DIBER, Anatoly

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/14532 ,  A61B5/6816 ,  A61B5/7203

Abstract: Examples disclosed herein provide a combination of measurement channels each having a pair of measuring sub-channels. Each sub-channel measures the glucose concentration by monitoring a physical variable dependent on the glucose concentration in the subject's tissue. The subchannels of each measurement channel are orthogonal towards a common disturbance acting on each subchannel of the apparatus. Ultrasonic, electromagnetic, and thermal channels may be implemented. The non-invasive glucose monitor comprises a processing unit, which drives these sub-channels' sensors. The sensors may be located on a sensor unit configured as an ear clip. The sensor unit may include ultrasonic piezo transducers positioned on opposing portions of the ear clip and thus configured to be on opposite sides of the ear lobe, capacitor plates positioned on opposing portions of the ear clip, and a heater and a sensor positioned on the ear clip in close juxtaposition to the ear lobe.

公开(公告)号：WO2011017355A2

公开(公告)日：2011-02-10

申请号：PCT/US2010/044292

申请日：2010-08-03

Applicant: ULTIMO MEASUREMENT, LLC ,  RAYKHMAN, Alexander, M. ,  LUBRANO, Francis, M. ,  NAIDIS, Eugene ,  KASHIN, Val, V. ,  KLIONSKY, Alex ,  COUTO, John

Inventor： RAYKHMAN, Alexander, M. ,  LUBRANO, Francis, M. ,  NAIDIS, Eugene ,  KASHIN, Val, V. ,  KLIONSKY, Alex ,  COUTO, John

IPC: G01N9/00 ,  G01N11/16 ,  G01N29/02

CPC classification number: G01N29/4472 ,  G01N9/002 ,  G01N11/16 ,  G01N29/045 ,  G01N2291/022 ,  G01N2291/02818

Abstract: Methods and apparatus for non-invasive, simultaneous determination of density and a shear resistance relating variable of a non-gaseous, free flowing material are presented. In one example, the non-gaseous free flowing material is disposed within a vessel at a known or constant level. According to this example, the method and apparatus utilizes an adjustable mathematical model to determine the density and a shear resistance relating variable based on measurements of the system comprising the filling material, the vessel wall and the dynamic measuring instrument interacting with the wall.

Abstract translation: 提出了非侵入性，同时测定非气态，自由流动材料的密度和剪切阻力相关变量的方法和装置。 在一个实例中，非气态自由流动材料以已知或恒定的水平设置在容器内。 根据该示例，该方法和装置利用可调数学模型来确定基于包括填充材料，容器壁和与壁相互作用的动态测量仪器的系统的测量的密度和剪切阻力相关变量。

公开(公告)号：WO2011135562A3

公开(公告)日：2011-11-03

申请号：PCT/IL2011/000328

申请日：2011-04-26

Applicant: A.D. INTEGRITY APPLICATIONS LTD. ,  GAL, Avner ,  RAYKHMAN, Alexander M. ,  NAIDIS, Eugene ,  MAYZEL, Yulia ,  KLIONSKY, Alexander ,  DIBER, Anatoly

Inventor： GAL, Avner ,  RAYKHMAN, Alexander M. ,  NAIDIS, Eugene ,  MAYZEL, Yulia ,  KLIONSKY, Alexander ,  DIBER, Anatoly

IPC: A61B5/145

Abstract: In order to increase the accuracy of non-invasive glucose measurement, the device uses a combination of three non-invasive methods: ultrasonic, electromagnetic and thermal. The non-invasive glucose monitor comprises a Main Unit, which drives three different sensor channels (one per technology), located on an external unit configured as an ear clip attached to the subject's ear lobe. To effect the ultrasonic channel, ultrasonic piezo elements are positioned on opposing portions of the ear clip and thus opposite sides of the ear lobe. For implementation of the electromagnetic channel, capacitor plates are positioned on opposing portions of the ear clip and the ear lobe serves as the dielectric. The thermal channel includes a heater and a sensor positioned on the ear clip in close juxtaposition to the ear lobe.

公开(公告)号：WO2011135562A2

公开(公告)日：2011-11-03

申请号：PCT/IL2011000328

申请日：2011-04-26

Applicant: AD INTEGRITY APPLICATIONS LTD ,  GAL AVNER ,  RAYKHMAN ALEXANDER M ,  NAIDIS EUGENE ,  MAYZEL YULIA ,  KLIONSKY ALEXANDER ,  DIBER ANATOLY

Inventor： GAL AVNER ,  RAYKHMAN ALEXANDER M ,  NAIDIS EUGENE ,  MAYZEL YULIA ,  KLIONSKY ALEXANDER ,  DIBER ANATOLY

IPC: A61B5/145

CPC classification number: A61B5/14532 ,  A61B5/6816

Abstract: In order to increase the accuracy of non-invasive glucose measurement, the device uses a combination of three non-invasive methods: ultrasonic, electromagnetic and thermal. The non-invasive glucose monitor comprises a Main Unit, which drives three different sensor channels (one per technology), located on an external unit configured as an ear clip attached to the subject's ear lobe. To effect the ultrasonic channel, ultrasonic piezo elements are positioned on opposing portions of the ear clip and thus opposite sides of the ear lobe. For implementation of the electromagnetic channel, capacitor plates are positioned on opposing portions of the ear clip and the ear lobe serves as the dielectric. The thermal channel includes a heater and a sensor positioned on the ear clip in close juxtaposition to the ear lobe.

Abstract translation: 为了提高非侵入性葡萄糖测量的准确性，该装置采用三种非侵入性方法的组合：超声波，电磁和热能。 非侵入式葡萄糖监测器包括主单元，其驱动三个不同的传感器通道（每个技术一个），位于配置为附接到被检者耳垂的耳夹的外部单元上。 为了实现超声波通道，超声波压电元件位于耳夹的相对部分上，并且因此位于耳垂的相对侧。 为了实现电磁通道，电容器板位于耳夹的相对部分上，耳垂片用作电介质。 热通道包括加热器和位于耳夹上的传感器，与耳垂并排放置。

公开(公告)号：WO2011017355A3

公开(公告)日：2011-07-07

申请号：PCT/US2010044292

申请日：2010-08-03

Applicant: ULTIMO MEASUREMENT LLC ,  RAYKHMAN ALEXANDER M ,  LUBRANO FRANCIS M ,  NAIDIS EUGENE ,  KASHIN VAL V ,  KLIONSKY ALEX ,  COUTO JOHN

Inventor： RAYKHMAN ALEXANDER M ,  LUBRANO FRANCIS M ,  NAIDIS EUGENE ,  KASHIN VAL V ,  KLIONSKY ALEX ,  COUTO JOHN

IPC: G01N9/00 ,  G01N11/16 ,  G01N29/02

CPC classification number: G01N29/4472 ,  G01N9/002 ,  G01N11/16 ,  G01N29/045 ,  G01N2291/022 ,  G01N2291/02818

Abstract: Methods and apparatus for non-invasive, simultaneous determination of density and a shear resistance relating variable of a non-gaseous, free flowing material are presented. In one example, the non-gaseous free flowing material is disposed within a vessel at a known or constant level. According to this example, the method and apparatus utilizes an adjustable mathematical model to determine the density and a shear resistance relating variable based on measurements of the system comprising the filling material, the vessel wall and the dynamic measuring instrument interacting with the wall.

Abstract translation: 介绍了非侵入性同时测定非气态自由流动材料的密度和抗剪力相关变量的方法和设备。 在一个实例中，非气态自由流动材料以已知或恒定水平布置在容器内。 根据该示例，该方法和设备利用可调节的数学模型来基于包括填充材料，血管壁和与壁相互作用的动态测量仪器的系统的测量来确定密度和抗剪力相关变量。

公开(公告)号：WO2010147598A1

公开(公告)日：2010-12-23

申请号：PCT/US2009/048010

申请日：2009-06-19

Applicant: DOLPHIN MEASUREMENT SYSTEMS, LLC ,  RAYKHMAN, Alexander, M. ,  NAIDIS, Eugene ,  WALDMAN, Ellis, S.

Inventor： RAYKHMAN, Alexander, M. ,  NAIDIS, Eugene ,  WALDMAN, Ellis, S.

IPC: G01R29/08 ,  G01R27/02 ,  G02B27/00

CPC classification number: G01B7/023 ,  B21B38/04 ,  G01B7/107

Abstract: A system and method for measurement of parameters of a conductive material, include generating an oscillating electromagnetic field (EMF) interacting with a sample portion from a remotely positioned source; measuring values of components of impedance of the electromagnetic; populating a system of equations including a theory of electromagnetism- based mathematical model of the electromagnetic system; solving the system of equations to calculate values of a distance between the sample portion and the source, thickness of the sample portion in proximity to a point of projection of the source onto the sample portion and electromagnetic properties of the sample portion; outputting the calculated values as the measured values; and repeating the steps of generating, populating, solving, outputting and repeating using the calculated values for the step of populating in place of the measured component values.

Abstract translation: 一种用于测量导电材料的参数的系统和方法，包括产生与来自远程位置的源相互作用的振荡电磁场（EMF）; 测量电磁阻抗分量值; 包括电磁系统的基于电磁学的数学模型理论的方程组; 求解方程式来计算样品部分和源之间的距离值，样品部分的厚度接近源到样品部分的投影点和样品部分的电磁特性; 输出计算值作为测量值; 并且使用用于填充的步骤的计算值来代替所测量的分量值来重复生成，填充，解决，输出和重复的步骤。