公开(公告)号：WO2022040321A1

公开(公告)日：2022-02-24

申请号：PCT/US2021/046515

申请日：2021-08-18

申请人： NATREON, INC.

发明人： KALIDINDI, Sanyasi R.

IPC分类号： A61P11/00 ,  A61P31/12 ,  A61P31/14

摘要： This disclosure is directed to methods of treating, preventing, and protecting against viral infection including coronavirus infection and symptoms such as in COVID-19 infection. The methods include the administration of a composition comprising an extract and/or extract component, specifically, plant and/or herbo-mineral extracts, such as of Shilajit, Withania somnifera, Asparagus racemosus, Terminalia chebula, Terminalia bellirica, Phyllanthus emblica, Azadirachta indica, and a trivalent chromium complex with extracts of P. emblica and Shilajit; and/or extract components such as 3,8-dihydroxy-6H-benzo[c]chromen-6-one and 3-hydroxy-6H-benzo[c]chromen-6-one.

公开(公告)号：WO2013070619A8

公开(公告)日：2014-05-08

申请号：PCT/US2012063727

申请日：2012-11-06

申请人： NATREON INC

发明人： GHOSAL SHIBNATH ,  VEERARAGAVAN MURUGANANDAM ,  KALIDINDI SANYASI R

IPC分类号： C07K16/00

CPC分类号： A61K31/585 ,  A61K36/38 ,  A61K47/541 ,  A61K47/545 ,  C07J71/001

摘要： A group of indolealkylamino-withasteroid conjugates, isolated and purified from Withania somnifera, are described. A synthetic method of making an indolealkylamino- withasteroid compound is provided. In vitro acetyl cholinesterase inhibitory activity and methods for treatment of dementia and dementia-related disorders, such as Alzheimer's disease, and anxiety and depressive disorders in mammals are demonstrated with these novel compositions.

摘要翻译： 描述了分离和纯化的从吲哚胺（Anania somnifera）中的一组吲哚烷基氨基 - 无主义结合物。 提供了制备吲哚烷基氨基 - 非甾体化合物的合成方法。 用这些新型组合物证明了体外乙酰胆碱酯酶抑制活性和用于治疗痴呆和痴呆相关疾病如阿尔茨海默病和哺乳动物中的焦虑和抑郁障碍的方法。

公开(公告)号：WO2006036638A1

公开(公告)日：2006-04-06

申请号：PCT/US2005/033538

申请日：2005-09-20

申请人： NATREON, INC.

发明人： GHOSAL, Shibnath

IPC分类号： A61K35/78

CPC分类号： A23F3/14 ,  A23F5/14 ,  A23F5/40 ,  A61K36/185 ,  A61K36/81 ,  A61K36/896 ,  A61K2300/00

摘要： An obesity control agent with health-restorative and health-promotional benefits to humans comprising the extract of Chlorophytum species, more particularly, Chlorophytum arundinacceum, is disclosed. The bioactive principles responsible for anti-obesity property have been determined to be mainly due to spirosta-steroidal saponins, spirosta-steroidal alkaloids and galacto-glucan oligosaccharides. Most effective as an obesity control agent is the spirosta-steroidal saponins. Pharmaceutical, nutritional and veterinary use of this inventive composition is also disclosed.

摘要翻译： 一种肥胖控制剂，其具有对人的健康恢复和健康促进益处，其包含

公开(公告)号：WO2003059313A1

公开(公告)日：2003-07-24

申请号：PCT/EP2003/000401

申请日：2003-01-16

申请人： MERCK PATENT GMBH ,  NATREON, Inc. ,  CHAUDHURI, Ratan, K. ,  MARCHIO, François

发明人： CHAUDHURI, Ratan, K. ,  MARCHIO, François

IPC分类号： A61K7/48

CPC分类号： A61K8/602 ,  A61K8/97 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02

摘要： A light colored standardized extract of Emblica officinalis consisting essentially of over 40% by weight of Emblicanin A. Emblicanin B, Pedunculagin and Punigluconin, and not more than about 1% by weight of flavonoids, and methods of producing same. Also disclosed are cosmetic or pharmaceutical compositions comprising the standardized extract and methods of using same to lighten or whiten skin.

摘要翻译： 主要由Emblicanin A. Emblicanin B，Pedunculagin和Punigluconin和不超过约1％重量的类黄酮组成的超过40％重量的Emblica officinalis的浅色标准提取物及其制备方法。 还公开了包含标准化提取物的化妆品或药物组合物和使用其来减轻或增白皮肤的方法。

公开(公告)号：WO2003035094A1

公开(公告)日：2003-05-01

申请号：PCT/US2002/025683

申请日：2002-08-13

申请人： NATREON INC. ,  INDIAN HERBS RESEARCH & SUPPLY COMPANY LTD.

发明人： GHOSAL, Shibnath

IPC分类号： A61K35/78

CPC分类号： A61K36/00

摘要： A stable, water-soluble delivery system which is a purified Shilajit composition obtained by extraction of native Shilajit, preferably containing at least 40% by weight of a carrier which is purified fulvic acid, characterized by having a sponge-like structure punctured by voids of about 200-1000 A in diameter, and a Mn molecular weight of about 700-2500; and an effective amount of an active pharmaceutical, nutritional or cosmetic ingredient added to said carrier and filling voids therein.

摘要翻译： 一种稳定的水溶性递送系统，其是通过提取天然Shilajit获得的纯化Shilajit组合物，优选含有至少40重量％的纯化的富里酸的载体，其特征在于具有由空隙形成的海绵状结构 直径约200-1000，Mn分子量约700-2500; 和有效量的活性药物，营养或化妆品成分加入到所述载体中并填充其中的空隙。

公开(公告)号：WO2023091390A1

公开(公告)日：2023-05-25

申请号：PCT/US2022/049905

申请日：2022-11-15

申请人： NATREON, INC.

发明人： KALIDINDI, Sanyasi R.

IPC分类号： A61P15/12 ,  A61K36/81 ,  A61K36/896 ,  A61P19/10

摘要： Provided herein are methods and compositions for asparagus racemosus and withania somnifera in treating the quality of life, improving endothelial function and biomarkers, bone health biomarkers, and bone mineral density (BMD) in postmenopausal women.

公开(公告)号：WO2022192413A1

公开(公告)日：2022-09-15

申请号：PCT/US2022/019572

申请日：2022-03-09

申请人： NATREON, INC.

发明人： KALIDINDI, Sanyasi R.

IPC分类号： A61K31/7048 ,  A61K36/185

摘要： Methods of relieving back pain with Terminalia chebula compositions are described.

公开(公告)号：WO2016054433A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/053587

申请日：2015-10-01

申请人： NATREON, INC.

发明人： SEN, Chandan, K.

IPC分类号： A61K8/97 ,  A61K8/98 ,  A61K35/10

CPC分类号： A61K35/02 ,  A61K8/965 ,  A61K8/97 ,  A61K8/98 ,  A61K8/99 ,  A61K31/352 ,  A61K31/366 ,  A61K31/538 ,  A61K35/10 ,  A61K38/1767 ,  A61Q19/08 ,  A61K2300/00

摘要： A method of using Shilajit or its individual components, or a combination of two or more of these components, to induce the body of a mammal, including that of a human, to synthesize new collagen and the related extracellular matrix proteins, thus promoting the health of all of the tissues and organs containing collagen and the related extracellular matrix proteins, including skin, connective tissue, muscle, cartilage, bone, and teeth and improve muscle building and regeneration, and/or treat collagen-related disorders is presented.

摘要翻译： 使用Shilajit或其单独组分或这些组分中的两种或更多种的组合来诱导哺乳动物（包括人类）的身体合成新的胶原蛋白和相关的细胞外基质蛋白的方法，从而促进健康 包括皮肤，结缔组织，肌肉，软骨，骨骼和牙齿的所有组织和器官以及相关的细胞外基质蛋白，并改善肌肉的建立和再生，和/或治疗胶原蛋白相关疾病。

公开(公告)号：WO2008016554A1

公开(公告)日：2008-02-07

申请号：PCT/US2007/016969

申请日：2007-07-30

申请人： NATREON, INC.

发明人： GHOSAL, Shibnath

IPC分类号： A61K38/00

CPC分类号： A61K31/122 ,  A23L2/52 ,  A23L33/10 ,  A61K8/347 ,  A61K8/442 ,  A61K31/37 ,  A61K35/10 ,  A61Q17/04 ,  A61Q19/08 ,  A61K2300/00

摘要： The present invention relates to a pharmaceutical or veterinary or nutritional or personal care composition comprising coenzyme Q 10 (CoQ I0 ), reduced CoQ 1O , or mixtures thereof and oxygenated dibenzo-α-pyrone or an amino acyl ester thereof. The composition of the present invention is able to support and/or provide therapy to individuals at risk and/or under treatment for dysfunctions of energy metabolism, and specifically, for mitochondrial diseases.

摘要翻译： 本发明涉及一种药用或兽医或营养或个人护理组合物，其包含辅酶Q 10（COQ 10），还原的COQ 10或 其混合物和氧化的二苯并-α-吡喃酮或其氨基酰基酯。 本发明的组合物能够支持和/或提供治疗患有风险和/或治疗能力代谢功能障碍，特别是针对线粒体疾病的个体。

公开(公告)号：WO2006078424A3

公开(公告)日：2006-11-23

申请号：PCT/US2005047105

申请日：2005-12-28

申请人： NATREON INC

发明人： GHOSAL SHIBNATH

IPC分类号： A61K36/00

CPC分类号： A61K36/22 ,  A61K36/10 ,  A61K36/81 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical or veterinary or nutritional compositions of polyherbal extracts useful as anti-viral or immune-supporting agents. Particularly, the present invention of polyherbal composition comprises of extracts of Withania somnifera, Mangifera indica and purified Shilajit. This cost effective immune-supporting agent is ideal for use during the maintenance phase of the treatment, following an initial viral load reduction phase in which it is used as an adjuvant to conventional anti-viral drug therapy. The anti-viral and immune-supporting composition of this invention can perhaps be the sole basis of treatment where affordability is an issue. Additionally, this composition is used for the treatment, prevention or management of immune-supporting system in primates in need, especially human.

摘要翻译： 本发明涉及可用作抗病毒剂或免疫支持剂的聚热提取物的药物或兽用或营养组合物。 特别地，本发明的聚合物组合物包含睡茄，芒果（Mangifera indica）和纯化的希拉吉特（Shilajit）的提取物。 在最初的病毒载量降低阶段之后，这种成本效益好的免疫支持剂对于在治疗的维持阶段期间使用是理想的，其中它用作常规抗病毒药物疗法的佐剂。 本发明的抗病毒和免疫支持组合物可能是可负担性问题的唯一治疗基础。 另外，该组合物用于治疗，预防或管理需要的灵长类动物免疫系统，特别是人类。