公开(公告)号：WO1991012794A1

公开(公告)日：1991-09-05

申请号：PCT/EP1991000267

申请日：1991-02-11

Applicant: NATTERMANN, A. & CIE. GMBH ,  LAUTENSCHLÄGER, Hans, Heiner ,  RÖDING, Joachim ,  GHYCZY, Miklos

Inventor： NATTERMANN, A. & CIE. GMBH

IPC: A61K09/127

CPC classification number: A61K9/127 ,  A61K8/14 ,  A61Q19/00

Abstract: Aqueous phospholipid dispersion, whose membranes are formed from a mixture of phosphatidylcholine and a specific phospholipid basic substance, provide a particularly favourable loading of the vesicle membrane with lipophilic substances. The vesicle dispersions prepared according to a particular method can be used for pharmaceutical and cosmetic compositions.

公开(公告)号：WO1990012565A1

公开(公告)日：1990-11-01

申请号：PCT/EP1990000621

申请日：1990-04-18

Applicant: NATTERMANN, A. & CIE. GMBH ,  LAUTENSCHLÄGER, Hans-Heiner ,  GHYCZY, Miklos ,  RÖDING, Joachim

Inventor： NATTERMANN, A. & CIE. GMBH

IPC: A61K09/127

CPC classification number: A61Q19/00 ,  A61K8/14 ,  A61K9/1277 ,  A61Q5/00

Abstract: Methods of preparing water-containing formulations of phospholipids in the presence of swelling accelerators and the use of the gels so formed for the preparation of liposomal formulations by dilution with water.

Abstract translation: 在溶胀促进剂存在下制备含磷配方的磷脂的方法以及如此形成的凝胶用于通过用水稀释制备脂质体制剂的方法。

公开(公告)号：WO1990008125A2

公开(公告)日：1990-07-26

申请号：PCT/EP1990000105

申请日：1990-01-19

Applicant: NATTERMANN, A. & CIE. GMBH ,  GÜNTHER, Bernd, Rainer ,  LOSCH, Rainer ,  LAUTENSCHLÄGER, Hans ,  STEINER, Klaus

Inventor： NATTERMANN, A. & CIE. GMBH

IPC: C07C59/01

CPC classification number: C07C59/01 ,  C07C51/367 ,  C07C51/38 ,  C07C59/245

Abstract: The invention refers to a novel method for the preparation of 8-hydroxyoctanoic acid by reaction of 6-chlorohexanol with a dialkyl malonate ester, thermal decarboxylation of the malonic acid derivative and isolation of the 8-hydroxyoctanoic acid as the free acid or as an alkali metal salt.

Abstract translation: 本发明涉及一种新的方法用于通过6-氯己醇的反应与丙二酸二烷基酯，在形式的8-羟基辛酸的丙二酸衍生物和隔离的热脱羧的酯制备8-羟基辛酸 游离酸或碱金属盐。