公开(公告)号：WO2006103550A1

公开(公告)日：2006-10-05

申请号：PCT/IB2006/000752

申请日：2006-03-31

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  NAYYAR, Sandeep ,  GUPTA, Mitu

Inventor： KUMAR, Naresh ,  NAYYAR, Sandeep ,  GUPTA, Mitu

IPC: C07D307/83 ,  C07D307/88

CPC classification number: C07D307/87 ,  C07D307/88

Abstract: The invention relates to processes for the preparation of 5-amino-2-benzofuran- l(3 H )-one of Formula (I), and to the use of this compound as an intermediate for the preparation of citalopram. The invention also relates to a process for the preparation of citalopram or a salt thereof, and pharmaceutical compositions that include the citalopram or a salt thereof.

Abstract translation: 本发明涉及制备式（I）的5-氨基-2-苯并呋喃-1（3H） - 酮的方法，以及该化合物作为制备西酞普兰的中间体的用途。 本发明还涉及制备西酞普兰或其盐的方法，以及包括西酞普兰或其盐的药物组合物。

公开(公告)号：WO2007029155A3

公开(公告)日：2007-08-30

申请号：PCT/IB2006053073

申请日：2006-09-01

Applicant: RANBAXY LAB LTD ,  KUMAR NARESH ,  NAYYAR SANDEEP ,  MAHENDRU MANU

Inventor： KUMAR NARESH ,  NAYYAR SANDEEP ,  MAHENDRU MANU

IPC: C07C273/18 ,  C07C275/42

CPC classification number: C07C273/189 ,  C07C275/42

Abstract: The present invention relates to an improved process for preparing pure celiprolol base in monohydrate form by crystallizing crude celiprolol base in one or more carboxylic acid ester solvents and its conversion to pharmaceutically acceptable acid addition salts, for example, celiprolol hydrochloride Form I in high purity.

Abstract translation: 本发明涉及一种通过在一种或多种羧酸酯溶剂中结晶粗硅藻土碱基并将其转化为药学上可接受的酸加成盐（例如，高纯度的盐酸赛立洛尔盐酸盐形式I）来制备一水合物形式的纯赖洛洛尔碱的改进方法。

公开(公告)号：WO2007029155A2

公开(公告)日：2007-03-15

申请号：PCT/IB2006/053073

申请日：2006-09-01

Applicant: RANBAXY LABORATORIES LIMITED ,  KUMAR, Naresh ,  NAYYAR, Sandeep ,  MAHENDRU, Manu

Inventor： KUMAR, Naresh ,  NAYYAR, Sandeep ,  MAHENDRU, Manu

CPC classification number: C07C273/189 ,  C07C275/42

Abstract: The present invention relates to an improved process for preparing pure celiprolol base in monohydrate form by crystallizing crude celiprolol base in one or more carboxylic acid ester solvents and its conversion to pharmaceutically acceptable acid addition salts, for example, celiprolol hydrochloride Form I in high purity.

Abstract translation: 本发明涉及通过在一种或多种羧酸酯溶剂中结晶粗塞利洛尔碱并将其转化为药学上可接受的酸加成盐来制备一水合物形式的纯塞利吡咯碱的改进方法，例如， 塞利洛尔盐酸盐晶型I，高纯度。