公开(公告)号：WO2015075645A1

公开(公告)日：2015-05-28

申请号：PCT/IB2014/066159

申请日：2014-11-19

Applicant: NBVD S.A.

Inventor： MANFREDINI, Gianluca ,  MERCURI, Rocco ,  ROVERI, Norberto ,  LELLI, Marco ,  MORSELLI, Silvana ,  CECCHINI, Alice ,  PIVA, Massimo

IPC: A01N25/04 ,  A01N25/08 ,  A01N25/12 ,  A01N59/02 ,  A01N59/20 ,  A01P3/00

CPC classification number: A01N25/04 ,  A01N25/08 ,  A01N25/12 ,  A01N59/02 ,  A01N59/20 ,  A01N57/20 ,  A01N59/16

Abstract: The subject matter of the invention is the use of a substituted or non- substituted hydroxyapatite particle as a carrier of bioactive molecules for the prevention and treatment of grapevine trunk disease, in particular esca disease of the vines. In a preferred embodiment the hydroxyapatite is substituted by at least one carbonate ion, corresponding to the formula: Ca (10) (P0 4 ) (6-y) (C0 3 ) y (OH) 2 wherein y is a number comprised between 0.002 and 0.030, and having a crystallinity degree comprised between 25 and 59 %. The invention also covers aggregates of these particles and compositions including these particles or aggregates.

Abstract translation: 本发明的主题是使用取代或未取代的羟基磷灰石颗粒作为生物活性分子的载体，用于预防和治疗葡萄树干疾病，特别是葡萄藤的esca病。 在优选的实施方案中，羟基磷灰石被至少一种碳酸根离子取代，对应于下式：Ca（10）（P04）（6-y）（C03）y（OH）2，其中y是0.002和0.030之间的数 ，结晶度为25〜59％。 本发明还包括这些颗粒和包括这些颗粒或聚集体的组合物的聚集体。

公开(公告)号：WO2016185379A1

公开(公告)日：2016-11-24

申请号：PCT/IB2016/052861

申请日：2016-05-17

Applicant: NBVD S.A.

Inventor： MANFREDINI, Gianluca ,  PIVA, Massimo ,  COLETTI, Matteo ,  BATTISTON, Enrico

IPC: A01N25/08 ,  A01N59/14 ,  A01N59/16 ,  A01N59/20 ,  A01N65/00 ,  A01N65/22 ,  A01N65/28 ,  A01N65/48

CPC classification number: A01N59/26 ,  A01N25/08 ,  A01N59/20 ,  A01N65/22 ,  A01N65/28 ,  A01N65/48 ,  C01B25/32 ,  A01N59/02 ,  A01N59/16 ,  A01N65/00

Abstract: The subject matter of the invention is a substituted hydroxyapatite carrier, responding to the formula: Ca (10-x) M x (PO 4 ) (6-y) (CO 3 ) y (OH) 2 in which: M is chosen from Cu, Mg, Zn, Pb, Cd, Ba, K, Mn, Mo, Fe, Ag, B, Se or a combination of at least two of such elements; - x is comprised between 0 and 2, preferably between 0 and 1, more preferably between 0 and 0.8, even more preferably between 0.02 and 0.05; - y is comprised between 0 and 2, preferably between 0 and 1, more preferably between 0.002 and 0.030, with the proviso that x and y are never equal to 0 at the same time. The substituted hydroxyapatite is a carrier of a bioactive substance chosen among a metal ion selected from Mn, Mg, K, Fe, B, Mo, Se and/o an extract of vegetal origin. The invention relates also to the use of the carrier for the delivery of such a bioactive substance to plants in order to achieve the phytosanitary and/or nutritional treatment of the plant.

Abstract translation: 本发明的主题是一种取代的羟基磷灰石载体，其响应式为：Ca（10-x）Mx（PO4）（6-y）（CO3）y（OH）2，其中：M选自Cu，Mg ，Zn，Pb，Cd，Ba，K，Mn，Mo，Fe，Ag，B，Se或这些元素中的至少两种的组合; -x为0〜2，优选为0〜1，更优选为0〜0.8，进一步优选为0.02〜0.05。 - y在0和2之间，优选在0和1之间，更优选在0.002和0.030之间，条件是x和y从不等于0同时。 取代的羟基磷灰石是选自Mn，Mg，K，Fe，B，Mo，Se的金属离子和/或植物提取物中的生物活性物质的载体。 本发明还涉及用于将这种生物活性物质递送到植物的载体的用途，以便实现植物的植物检疫和/或营养治疗。

公开(公告)号：WO2016185380A1

公开(公告)日：2016-11-24

申请号：PCT/IB2016/052863

申请日：2016-05-17

Applicant: NBVD S.A.

Inventor： PIVA, Massimo ,  COLETTI, Matteo ,  BATTISTON, Enrico ,  MANFREDINI, Gianluca

IPC: A01N25/08 ,  A01N59/02 ,  A01N59/14 ,  A01N59/16 ,  A01N59/20 ,  A01N65/00 ,  A01N65/22 ,  A01N65/28 ,  A01N65/48

CPC classification number: A01N25/08 ,  A01N59/02 ,  A01N59/14 ,  A01N59/20 ,  A01N65/22 ,  A01N65/28 ,  A01N65/48 ,  A01N59/16 ,  A01N65/00

Abstract: The subject matter of the invention is a hydroxyapatite carrier, corresponding to the formula : Ca (10-x) M x (PO 4 ) (6-y) (CO 3 ) y (OH) 2 in which: M is chosen from Cu, Mg, Zn, Pb, Cd, Ba, K, Mn, Mo, Fe, Ag, B, Se or a combination of at least two of such elements; - x is comprised between 0 and 2, preferably between 0 and 1, more preferably between 0 and 0.8, even more preferably between 0.02 and 0.05; - y is comprised between 0 and 2, preferably between 0 and 1, more preferably between 0.002 and 0.030, The hydroxyapatite is a carrier of a bioactive substance chosen among a metal ion selected from Cu, Zn, S, Mn, Mg, K, Fe, B, Mo, Se and/or an extract of vegetal origin. The bioactive substances are active in the treatment of vascular diseases of plants, in particular: grapevine yellows (caused by grapevine phytoplasma), bacterial canker in kiwifruit (caused by Pseudomonas syringae), olive quick decline syndrome (caused by Xylella fastidiosa) and Citrus bacterial canker disease (caused by Xanthomonas axonopodis).

Abstract translation: 本发明的主题是羟基磷灰石载体，对应于下式：Ca（10-x）Mx（PO 4）（6-y）（CO 3）y（OH）2，其中：M选自Cu， Zn，Pb，Cd，Ba，K，Mn，Mo，Fe，Ag，B，Se或这些元素中的至少两种的组合; -x为0〜2，优选为0〜1，更优选为0〜0.8，进一步优选为0.02〜0.05。 -y包括0和2之间，优选在0和1之间，更优选在0.002和0.030之间。羟基磷灰石是选自Cu，Zn，S，Mn，Mg，K中的金属离子中的生物活性物质的载体， Fe，B，Mo，Se和/或植物来源的提取物。 生物活性物质对植物血管疾病的治疗具有积极的作用，特别是葡萄黄（由葡萄植物血浆引起），猕猴桃中的细菌溃疡（由丁香假单胞菌引起），橄榄快速下降综合征（由Xylella fastidiosa引起）和柑橘细菌 溃疡病（由黄单胞菌属引起的）。

公开(公告)号：WO2015075644A1

公开(公告)日：2015-05-28

申请号：PCT/IB2014/066158

申请日：2014-11-19

Applicant: NBVD S.A.

Inventor： MANFREDINI, Gianluca ,  MERCURI, Rocco ,  ROVERI, Norberto ,  LELLI, Marco ,  MORSELLI, Silvana ,  CECCHINI, Alice ,  PIVA, Massimo

IPC: A01N59/02 ,  A01N57/20 ,  A01N59/16 ,  A01N59/20 ,  A01N25/04 ,  A01N25/08 ,  A01N25/12 ,  A01P3/00 ,  A01P7/00 ,  A01P13/00

CPC classification number: A01N25/04 ,  A01N25/08 ,  A01N25/12 ,  A01N59/02 ,  A01N59/20 ,  A01N57/20 ,  A01N59/16

Abstract: The patent application relates to a substituted hydroxyapatite particle comprising a bioactive agent, aggregates of these particles and compositions comprising these particles or aggregates, as well as their use for treating plants for phytosanitary and/or nutritional purposes.

Abstract translation: 该专利申请涉及包含生物活性剂的取代羟基磷灰石颗粒，这些颗粒的聚集体和包含这些颗粒或聚集体的组合物，以及它们用于处理植物用于植物检疫和/或营养目的的用途。