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    OLIGOMER-ANTICHOLINERGIC AGENT CONJUGATES
    1.
    发明申请
    OLIGOMER-ANTICHOLINERGIC AGENT CONJUGATES 审中-公开
    低分子抗生素合剂

    公开(公告)号：WO2008112261A1

    公开(公告)日：2008-09-18

    申请号：PCT/US2008/003296

    申请日：2008-03-13

    Applicant: NEKTAR THERAPEUTICS AL, CORPORATION ,  RIGGS-SAUTHIER, Jennifer ,  DENG, Bo-liang

    Inventor： RIGGS-SAUTHIER, Jennifer ,  DENG, Bo-liang

    IPC: A61K47/48

    CPC classification number: C07C69/736 ,  A61K47/60

    Abstract: The invention provides anticholinergic agents that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different as compared to the characteristics of the anticholinergic agent not attached to the water-soluble oligomer.

    Abstract translation: 本发明提供通过共价连接水溶性低聚物进行化学修饰的抗胆碱能药。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的抗胆碱能药物的特征相比不同的特征。

    METHOD FOR PREPARING BRANCHED FUNCTIONALIZED POLYMERS USING BRANCHED POLYOL CORES
    6.
    发明申请
    METHOD FOR PREPARING BRANCHED FUNCTIONALIZED POLYMERS USING BRANCHED POLYOL CORES 审中-公开
    使用分支多元醇制备分支官能化聚合物的方法

    公开(公告)号：WO2007011802A1

    公开(公告)日：2007-01-25

    申请号：PCT/US2006/027529

    申请日：2006-07-18

    Applicant: NEKTAR THERAPEUTICS AL, CORPORATION ,  MCMANUS, Samuel, P. ,  KOZLOWSKI, Antoni

    Inventor： MCMANUS, Samuel, P. ,  KOZLOWSKI, Antoni

    IPC: C08G65/00 ,  C08G65/02 ,  C08G65/32 ,  C07B41/04 ,  A61K31/74

    CPC classification number: A61K47/48061 ,  A61K31/74 ,  A61K31/765 ,  A61K47/60 ,  C07D405/14 ,  C08G65/329 ,  C08G65/34 ,  C08G65/48 ,  C08G71/04 ,  C08L2203/02 ,  Y02P20/582

    Abstract: A method of preparing a multiarm polymer includes reacting a branched polyol with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, Y, to form a mixture comprising (i) unsubstituted branched polyol containing no Y groups; (ii) a monosubstituted polyol comprising one Y group, and (iii) a multisubstituted polyol (e.g., a disubstituted polyol comprising two Y groups); followed by purifying the mixture to separate the monosubstituted polyol from other species Thereafter, a water-soluble and non-peptidic polymer segment is attached to the monosubstituted branched polyol at the site of at least one of the hydroxyl groups. The invention also provides purified monosubstituted branched polyols and multiarm polymers prepared by the method and polyol precursors for use in the method.

    Abstract translation: 制备多聚合物聚合物的方法包括使支化多元醇与一种或多种官能化试剂反应以实现可离子化官能团或受保护的可离子化官能团Y的取代，以形成包含（i）不含Y基团的未取代的支链多元醇 ; （ii）包含一个Y基团的单取代多元醇，和（iii）多取代多元醇（例如，包含两个Y基团的二取代多元醇）; 然后纯化混合物以从其它物质分离单取代的多元醇然后，在至少一个羟基的位置处将水溶性和非肽聚合物链段连接到单取代的支化多元醇上。 本发明还提供了纯化的单取代的支化多元醇和通过该方法制备的多聚合物聚合物和用于该方法的多元醇前体。

    CONJUGATES OF AN hGH MOIETY AND A POLYMER
    8.
    发明申请
    CONJUGATES OF AN hGH MOIETY AND A POLYMER 审中-公开
    hGH环糊精和聚合物的结合

    公开(公告)号：WO2006102659A2

    公开(公告)日：2006-09-28

    申请号：PCT/US2006/011126

    申请日：2006-03-23

    Applicant: NEKTAR THERAPEUTICS AL, CORPORATION ,  BOSSARD, Mary J. ,  ZHANG, Ping

    Inventor： BOSSARD, Mary J. ,  ZHANG, Ping

    CPC classification number: A61K38/27 ,  A61K47/60

    Abstract: Conjugates of an hGH moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making the conjugates, and methods of administering compositions comprising such conjugates to a mammalian subject.

    Abstract translation: 提供hGH部分和一种或多种非肽水溶性聚合物的缀合物。 通常，非肽水溶性聚合物是聚（乙二醇）或其衍生物。 还提供了包含这种缀合物的组合物，制备缀合物的方法，以及向哺乳动物受试者施用包含此类缀合物的组合物的方法。

    STABILIZED POLYMERIC THIOL REAGENTS
    9.
    发明申请
    STABILIZED POLYMERIC THIOL REAGENTS 审中-公开
    稳定的聚合物THIOL试剂

    公开(公告)号：WO2006069388A2

    公开(公告)日：2006-06-29

    申请号：PCT/US2005/047337

    申请日：2005-12-21

    Applicant: NEKTAR THERAPEUTICS AL, CORPORATION ,  KOZLOWSKI, Antoni ,  MCMANUS, Samuel

    Inventor： KOZLOWSKI, Antoni ,  MCMANUS, Samuel

    IPC: A61K47/48

    CPC classification number: A61K47/48215 ,  A61K31/415 ,  A61K47/60 ,  C07C323/12 ,  C07D213/70 ,  C07D213/71

    Abstract: Disclosed are water soluble polymeric reagents comprising the structure POLY-[Y-S-W] x ,, where POLY is a water soluble polymer; Y is a hydrocarbon­based spacer group, x is 1 to 25, and S-W is a thiol, protected thiol, or thiol-reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use.

    Abstract translation: 公开了包含结构POLY- [Y-S-W] x N的水溶性聚合物试剂，其中POLY是水溶性聚合物; Y是烃基间隔基，x是1至25，且S-W是硫醇，被保护的硫醇或硫醇反应性衍生物。 优选地，水溶性聚合物是PEG聚合物。 还公开了这些聚合物试剂与药学上相关的分子的缀合物，以及它们的形成和用途的方法。

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