公开(公告)号：WO2012032053A1

公开(公告)日：2012-03-15

申请号：PCT/EP2011/065402

申请日：2011-09-06

Applicant: IT'IS Foundation ,  CAPSTICK, Myles ,  KUSTER, Niels ,  KUEHN, Sven ,  NEUFELD, Esra

Inventor： CAPSTICK, Myles ,  KUSTER, Niels ,  KUEHN, Sven ,  NEUFELD, Esra

IPC: A61B18/18 ,  A61N1/40 ,  A61N5/02

CPC classification number: A61B18/18 ,  A61B18/12 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00827 ,  A61B2018/00869 ,  A61B2018/00892 ,  A61N1/403

Abstract: The invention concerns a system for producing specific field distributions in a defined volume or region. The system comprises an array of electromagnetic field generating elements each with an integrated sensor for measuring the phase and amplitude of the current flowing in a metallic element (antenna or coil) or field in a slot based element, a measurement device to enable measurement of both phase and amplitude of the electrical signals from the sensors with sufficient dynamic range for quantification of the signal, a multi channel radio frequency power source with individually controllable amplitude and phase to excite each of the electromagnetic field generating elements, and a feedback controller enabling controlled adjustment of the amplitude and phase of the radio frequency power source based on the signals from the sensors. The system controls the outputs of a multi channel radio frequency power source such that the current in a metallic or the field in a slot based electromagnetic field generating elements provide the desired electromagnetic field values and the superposition of the fields produced by each electromagnetic field generating element produces said specific electromagnetic field distribution in said defined volume or region. As the signal picked up by each sensor is directly related to the phase and amplitude of the current or field in the associated electromagnetic field generating element and hence the electromagnetic field generated by the array elements, where the current or field measured is the sum of both the applied (from the radio frequency power source) and secondary excitations from mutual coupling and reflections hence the measured value represents the ideal excitation in the absence of mutual coupling, reflections and mismatch. The feedback controller modifies the direct excitation such that the total excitation is the ideal array excitation without coupling or mismatch. The invention implicitly corrects for the coupling and mismatch without explicit knowledge of, and calculation based on, the mutual coupling and mismatch, termed the coupling matrix, such that changes in the coupling matrix due to presence of objects or changes thereof are inherently taken into account. Additionally, by sequentially exciting each element in turn the invention can directly determine the exact mutual coupling matrix of the array even in the presence of variations in source impedance and undefined cable lengths such that initial excitation amplitudes and phases can be calculated to allow rapid adjustment to the desired values. A particular application of interest is in radio frequency hyperthermia applicator systems.

Abstract translation: 本发明涉及用于在限定的体积或区域中产生特定场分布的系统。 该系统包括一组电磁场产生元件，每个电磁场产生元件具有用于测量在金属元件（天线或线圈）中流动的电流的相位和幅度的集成传感器或基于时隙的元件中的场的测量装置， 来自传感器的电信号的相位和幅度具有用于量化信号的足够的动态范围，具有单独可控幅度和相位以激发每个电磁场产生元件的多通道射频电源，以及启用受控调整的反馈控制器 基于来自传感器的信号的射频电源的振幅和相位。 系统控制多通道射频电源的输出，使得基于时隙的电磁场产生元件中的金属或场中的电流提供期望的电磁场值，并且由每个电磁场产生元件产生的场的叠加 在所述限定的体积或区域中产生所述特定电磁场分布。 由于每个传感器拾取的信号与相关联的电磁场产生元件中的电流或场的相位和幅度直接相关，并且因此与由阵列元件产生的电磁场直接相关，其中所测量的电流或场是两者之和 应用（来自射频电源）和辅助激励与互耦合和反射，因此测量值表示在不存在互耦合，反射和失配的情况下的理想激励。 反馈控制器修改直接激励，使得总激励是没有耦合或失配的理想阵列激励。 本发明隐含地校正了耦合和失配，而没有明确地知道并且基于称为耦合矩阵的相互耦合和失配的计算，使得由于存在对象或其变化而导致的耦合矩阵的变化被固有地考虑 。 此外，通过依次激励每个元件，本发明可以直接确定阵列的精确互耦矩阵，即使存在源阻抗和未定义电缆长度的变化，使得可以计算初始激励幅度和相位，以允许快速调整 所需的值。 感兴趣的具体应用是射频高热敷贴器系统。