公开(公告)号：WO2019090432A1

公开(公告)日：2019-05-16

申请号：PCT/CA2018/051422

申请日：2018-11-09

Applicant: NEURESCENCE INC.

Inventor： BOELEN, Sander Johannes

IPC: G02B6/32 ,  A61B1/07 ,  A61B1/313 ,  G02B6/38 ,  G02B7/04

CPC classification number: G02B6/322 ,  A61B1/07 ,  A61B1/313 ,  G02B6/381 ,  G02B23/2476 ,  G02B23/26

Abstract: An optical imaging connector connects an optical fiber to a lens located adjacent to an imaging target, such as the brain tissue of a laboratory animal. A fiber assembly of the connector includes a ferrule holding the fiber and a ferrule adapter with a radially- extending coupler. The fiber assembly is removably joined to a lens assembly that holds the lens adjacent to a receptacle in which the ferrule is inserted coaxial to the lens. The lens holder has a radially-extending coupler that engages the coupler of the ferrule adapter to hold the two assemblies together. A focus adjustment mechanism, such as a screw, is manually adjustable by a user to change the position of the second coupler relative to the lens holder, and thereby change the axial position of the ferrule in the ferrule receptacle. One or more magnets may be used to provide a mutual attraction between the couplers.

公开(公告)号：WO2016019458A1

公开(公告)日：2016-02-11

申请号：PCT/CA2015/050731

申请日：2015-08-04

Applicant: NEURESCENCE INC.

Inventor： SOUDAGAR, Yasaman

IPC: G02B6/42 ,  A61B1/00 ,  A61B1/04 ,  G02B27/10 ,  G02B6/27 ,  G02B6/293

CPC classification number: A61B1/07 ,  A61B1/00 ,  A61B1/00016 ,  A61B1/00032 ,  A61B1/00167 ,  A61B1/04 ,  A61B1/043 ,  A61B1/055 ,  G02B6/06 ,  G02B6/27 ,  G02B6/276 ,  G02B6/293 ,  G02B6/42 ,  G02B6/4298 ,  G02B21/12 ,  G02B21/361

Abstract: A multiple target optical imaging apparatus performs optical imaging of a plurality of physically-separated imaging sites using a light source, a two-dimensional detector and a plurality of fiber bundles. Each fiber bundle has a distal end positioned adjacent to a different one of the imaging sites, and conveys source light from its proximal end to its distal end, while conveying an optical signal from its respective imaging site from its distal end to its proximal end. The optical signals may be simultaneously detected on different regions of the detector. The system is small, and may be used to image sites on an ambulatory animal, with the light source and detector located in a portable housing attached to the animal. Different types of imaging may be used, including fluorescence imaging, hyperspectral imaging, or polarization imaging.

Abstract translation: 多目标光学成像装置使用光源，二维检测器和多个光纤束对多个物理分离的成像部位进行光学成像。 每个纤维束具有邻近不同的成像部位定位的远端，并将源光从其近端传送到其远端，同时将光信号从其相应的成像部位从其远端传送到其近端。 可以在检测器的不同区域上同时检测光信号。 该系统很小，可用于对动物进行成像，其中光源和检测器位于与动物相连的便携式外壳中。 可以使用不同类型的成像，包括荧光成像，高光谱成像或偏振成像。