公开(公告)号：WO2009058346A1

公开(公告)日：2009-05-07

申请号：PCT/US2008/012338

申请日：2008-10-31

Applicant: WYETH ,  LAVALLIE, Edward, Roland ,  COLLINS-RACIE, Lisa Anne ,  CORCORAN, Christopher, John ,  TCHISTIAKOVA, Lioudmila, Gennadievna ,  NOWAK, John, Adam ,  KARIM, Riyez ,  TAN, Xiang-Yang ,  MARQUETTE, Kimberly, Ann ,  VELDMAN, Geertruida, Machteld

Inventor： LAVALLIE, Edward, Roland ,  COLLINS-RACIE, Lisa Anne ,  CORCORAN, Christopher, John ,  TCHISTIAKOVA, Lioudmila, Gennadievna ,  NOWAK, John, Adam ,  KARIM, Riyez ,  TAN, Xiang-Yang ,  MARQUETTE, Kimberly, Ann ,  VELDMAN, Geertruida, Machteld

IPC: C07K16/22

CPC classification number: C07K16/22 ,  A61K39/395 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes specific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof that may inhibit GDF8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, preventing, ameliorating, and treating GDF8 associated disorders, e.g., degenerative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such disorders by using the antibodies, polypeptides, polynucleotides, and vectors of the invention.

Abstract translation: 本公开提供了与生长和分化因子8（GDF8）有关的新分子，特别是GDF8特异性表位和GDF8特别是抗GDF8抗体或抗原结合蛋白或其片段的其他特异性拮抗剂，其可抑制体外GDF8活性和信号， /或体内。 本公开还提供用于检测和定量GDF8的免疫测定。 本公开还提供了用于诊断，预防，改善和治疗GDF8相关疾病例如肌肉，骨骼和胰岛素代谢的退行性顺序的方法。 最后，本公开提供了通过使用本发明的抗体，多肽，多核苷酸和载体来治疗这种疾病的药物。