公开(公告)号：WO2015073742A1

公开(公告)日：2015-05-21

申请号：PCT/US2014/065570

申请日：2014-11-13

Applicant: OAKWOOD HEALTHCARE, INC.

Inventor： SPEARS, Dr. James R.

IPC: A61M25/00

CPC classification number: A61M25/0023 ,  A61M5/1407 ,  A61M5/142 ,  A61M5/172 ,  A61M5/482 ,  A61M5/484 ,  A61M25/003 ,  A61M25/0041 ,  A61M25/007 ,  A61M39/10 ,  A61M2005/006 ,  A61M2205/3337 ,  A61M2205/502 ,  A61M2210/12 ,  A61M2210/125 ,  A61M2210/127

Abstract: Catheters (e.g., 10, 10', 210) for infusion of cardiovascular fluids into blood are disclosed. The cardiovascular fluid may, for example, comprise water highly supersaturated with a gas such as oxygen. Each catheter comprises one or more capillary tubings (or capillaries) through which a cardiovascular fluid flows. The distal end of each capillary (e.g., 20, 20') is mounted (e.g., potted) preferably flush with an external surface (e.g., 48) of a catheter sidewall (e.g., 38), while the proximal end (e.g., 28) of each capillary is in fluid communication with a cardiovascular fluid flowing through the lumen of the catheter. The combination of the catheter shape and the orientation of the distal end of each capillary relative to the longitudinal axis of the catheter provides control over the mixing pattern of the cardiovascular fluid with blood flowing within a vascular space such as an aorta.

Abstract translation: 公开了用于将血液流体输注到血液中的导管（例如10,10'，210）。 心血管流体可以例如包含用气体如氧气高度过饱和的水。 每个导管包括一个或多个毛细血管（或毛细血管），心血管流体通过毛细血管流动。 每个毛细管的远端（例如，20,20'）安装（例如，盆栽），优选地与导管侧壁（例如38）的外表面（例如48）齐平，而近端（例如，28 ）与流过导管内腔的心血管流体流体连通。 导管形状和每个毛细管的远端相对于导管的纵向轴线的取向的组合提供对心血管流体与诸如主动脉之类的血管空间内流动的血液的混合模式的控制。

公开(公告)号：WO2015148499A1

公开(公告)日：2015-10-01

申请号：PCT/US2015/022237

申请日：2015-03-24

Applicant: OAKWOOD HEALTHCARE, INC.

Inventor： SPEARS, James Richard

IPC: A61M15/00 ,  A61M15/02 ,  A61K49/22 ,  B65D83/30 ,  B05B7/04 ,  B01F3/04 ,  B65D83/62

CPC classification number: A61M5/007 ,  A61J1/20 ,  A61M13/003 ,  B05B7/0425 ,  B65D83/303 ,  B65D83/62

Abstract: Disclosed is a system to generate bubbles (90) from nucleations sites (80) in a flow of liquid saturated with a gas. The nucleation sites (90) may be hydophobic regions or domains, that allow bubble nucleation. The bubbles (90) may be formed to include a substantially or medically pure gas. The bubbles (90) may be formed on demand and in a selected small size.

Abstract translation: 公开了一种在气体饱和的液体流中从成核位置（80）产生气泡（90）的系统。 成核位点（90）可以是允许气泡成核的疏水区域或结构域。 气泡（90）可以形成为包括基本上或医学上纯的气体。 气泡（90）可以根据需要和选定的小尺寸形成。

公开(公告)号：WO2019074947A1

公开(公告)日：2019-04-18

申请号：PCT/US2018/055047

申请日：2018-10-09

Applicant: OAKWOOD HEALTHCARE, INC.

Inventor： SPEARS, James Richard

IPC: A61M5/00 ,  A61J1/20 ,  H01J37/20

CPC classification number: A61M5/007 ,  A61M5/00

Abstract: Generation of bubbles is disclosed to occur within a flow of an aqueous fluid. The bubbles may be formed within a tube of a selected diameter and the bubbles are controlled to exit the tube at a selected diameter. Generally, bubbles are formed to include a diameter of less than 1 millimeter, including less than about 20 microns.