公开(公告)号：WO2023281508A1

公开(公告)日：2023-01-12

申请号：PCT/IL2022/050726

申请日：2022-07-06

申请人： ADENOCYTE LTD.

发明人： ADAM, Dan ,  MORRISON, Kyle

IPC分类号： A61N7/00 ,  G01N33/574 ,  A61B10/02 ,  A61B10/00 ,  A61B17/22 ,  A61B8/00 ,  A61B8/08 ,  A61B17/32 ,  A61B17/00 ,  A61M37/00 ,  A61K38/22 ,  A61K49/22

摘要： A method and apparatus for producing an organ-sized area of stable microbubble cavitation including insonating an organ of a patient using Low Intensity Non-Focused Ultrasound (LINFU) at a first setting, monitoring the organ to detect presence of desired stable cavitation microbubble resonance and presence of unwanted inertial cavitation, when the presence of stable cavitation microbubble resonance is not detected then adjusting insonation parameters so as to increase the level of insonation, and when inertial cavitation is detected then adjusting the insonation parameters so as to decrease the level of insonation. Related apparatus and methods are also described.

公开(公告)号：WO2022212446A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022459

申请日：2022-03-30

申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

发明人： SHAR, Angela ,  RAZAVI, Mehdi

IPC分类号： A61B5/00 ,  A61K49/22

摘要： Compositions, methods, and kits relating to ultrasound targeted nanobubble compositions are disclosed. The nanobubble compositions comprise a hollow core containing at least one gas; at least one therapeutic agent disposed in the hollow core; a polymer shell encircling the hollow core; and at least one targeting agent incorporated in the polymer shell. Methods of producing and using the nanobubble compositions are also disclosed.

公开(公告)号：WO2022160987A1

公开(公告)日：2022-08-04

申请号：PCT/CN2021/138062

申请日：2021-12-14

申请人： 中国科学院深圳先进技术研究院

发明人： 严飞 ,  谢丽婷

IPC分类号： A61K49/22 ,  A61K47/68 ,  A61K47/55 ,  A61P25/00 ,  A61P25/14 ,  A61P25/08 ,  A61P25/16 ,  A61P25/24 ,  A61P25/30 ,  A61P25/20

摘要： 一种离子通道靶向微泡及其制备方法和应用，其包括壳膜和生物惰性气体，生物惰性气体封于壳膜围合形成的囊体内，壳膜外表面结合有离子通道抗体。该离子通道靶向微泡通过离子通道抗体与离子通道靶向结合，可增强超声神经刺激响应的灵敏度。

公开(公告)号：WO2022139583A1

公开(公告)日：2022-06-30

申请号：PCT/NL2021/050786

申请日：2021-12-23

申请人： SOLSTICE PHARMACEUTICALS B.V.

发明人： VAN HOEVE, Willem ,  GIANNASI, Katharine Jennifer ,  DE VARGAS SERRANO, Miguel ,  VAN DER PLAS, Renzo Bouwe

IPC分类号： A61K49/22 ,  A61M5/00 ,  B01F23/232 ,  B01F23/2373 ,  B01F33/30 ,  B01F101/00

摘要： The present invention is related to a cartridge. More in particular, the present invention relates to a cartridge by which a phospholipid composition, held in the cartridge can be mixed, within the cartridge, with a further liquid held in the cartridge or with a pressurized gas. The present invention further relates to a cartridge system comprising such a cartridge and a device in which the cartridge can be releasably inserted, wherein the device is configured for providing pressurized gas(ses) to be used as propellant(s) for moving the liquid(s) inside the cartridge for the purpose of mixing the liquid(s), and/or to be used as gas to be mixed.

公开(公告)号：WO2022108414A1

公开(公告)日：2022-05-27

申请号：PCT/KR2021/017240

申请日：2021-11-23

申请人： 한국표준과학연구원 ,  한밭대학교 산학협력단

发明人： 위정섭 ,  이태걸 ,  이진형 ,  나희경

IPC分类号： A61K49/18 ,  A61K49/22 ,  A61K49/00 ,  A61K9/51

摘要： 본 발명은 바이오 이미징 또는 약물전달에 효과적으로 활용될 수 있는 나노입자에 관한 것으로, 본 발명에 따른 나노입자는 플라즈모닉 금속 나노디스크; 및 상기 플라즈모닉 금속 나노디스크 상에 적층된 무기 나노디스크;를 포함하며, 상기 플라즈모닉 금속 나노디스크 단독의 공진 파장보다 장파장의 공진 파장을 갖는다.

公开(公告)号：WO2022078878A1

公开(公告)日：2022-04-21

申请号：PCT/EP2021/077785

申请日：2021-10-07

申请人： PARIS SCIENCES ET LETTRES ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSIDADE ESTADUAL DE CAMPINAS ,  FACULDADES CATOLICAS ASSOCIACAO SEM FINS LUCRATIVOS, MANTENEDORA DA PONTIFICIA, UNIVERSIDADE CATOLICA DO RIO DE JANEIRO(PUC-RIO)

发明人： SOYSAL, Ugur ,  NIECKELE AZEVEDO, Pedro ,  TABELING, Patrick ,  GAZIOLA DE LA TORRE, Lucimara ,  COSTA SILVA NORONHA PESSOA, Amanda ,  DA SILVEIRA CARVALHO, Marcio ,  MARTIN, Elian

IPC分类号： B01J13/04 ,  A61K9/127 ,  A61K9/50 ,  A61K47/69 ,  A61K49/22

摘要： The present invention to freeze-dried monodisperse microbubbles. The invention also relates to a process for preparing said microbubbles using microfluidic techniques. The microbubbles according to the present invention show interesting properties, making them particularly useful in applications that require monodispersity of the microbubbles.

公开(公告)号：WO2022038083A1

公开(公告)日：2022-02-24

申请号：PCT/EP2021/072696

申请日：2021-08-16

申请人： ETH ZURICH

发明人： YANIK, Mehmet ,  OZDAS, Mehmet ,  SHAH, Aagam ,  JOHNSON, Paul

IPC分类号： A61K9/00 ,  A61K9/51 ,  A61K41/00 ,  A61K49/22

摘要： In a method for enhancing localized delivery of a diagnostic or therapeutic agent using focused ultrasound (FUS), ultrasound-controllable drug carriers are administered into a blood vessel. Each drug carrier comprises an ultrasound-sensitive microbubble loaded with the diagnostic or therapeutic agent. The drug carriers are aggregated inside the vessel both along a radial direction and a longitudinal direction by application of an aggregation FUS sequence. Subsequently the diagnostic or therapeutic agent is released from the drug carriers by application of an uncaging FUS sequence. The aggregation and uncaging sequences are applied using FUS below a threshold power level such that harmful cavitation is avoided, as evidenced by the absence of broadband emissions and preferably non-integer harmonics from an emission spectrum of the drug carriers. Thereby damage to the vasculature by the FUS sequence is avoided. The method can in particular be employed to deliver drugs to the brain without opening the blood-brain barrier.

公开(公告)号：WO2022034176A2

公开(公告)日：2022-02-17

申请号：PCT/EP2021/072510

申请日：2021-08-12

申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

发明人： QIU, Tian ,  FISCHER, Peer

IPC分类号： A61K9/50 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61K51/12 ,  B32B15/02 ,  C09B67/02 ,  A61K49/0419 ,  A61K49/1818 ,  A61K49/223 ,  A61K51/1265 ,  A61K9/5094 ,  C09B67/0097

摘要： The invention relates to a delivery device formed by an aggregation of a plurality of individual particles in a host fluid, wherein one or more individual particles of the plurality of individual particles has a density of less than the host fluid, preferably less than water, and a bonding property which permits the initially separate individual particles to aggregate in said host fluid, i.e. to be connected one to another in said host fluid, to form the aggregation. The invention further relates to a method for producing a plurality of individual particles and to a method of forming a delivery device from a plurality of particles in a host fluid at an aggregation site.

公开(公告)号：WO2022026628A1

公开(公告)日：2022-02-03

申请号：PCT/US2021/043578

申请日：2021-07-28

申请人： CAO GROUP, INC

发明人： JENSEN, Steven D.

IPC分类号： A61K49/00 ,  A61K49/22

摘要： Shelf stable indocyanine green solutions are made by dissolving indocyanine green in an organic solvent with no water content. Such solutions may be self-stable for up to a year at room temperature when stored in air-tight containers. Solutions may then be used conventionally in imaging procedures in the medical and dental fields.

公开(公告)号：WO2022001255A1

公开(公告)日：2022-01-06

申请号：PCT/CN2021/084087

申请日：2021-03-30

申请人： 南京超维景生物科技有限公司

发明人： 董飞宏 ,  安健 ,  张嘉宾 ,  郭雯雨 ,  张珏

IPC分类号： A61K49/22 ,  A61K49/00 ,  A61K41/00 ,  A61K9/06 ,  B82Y40/00 ,  B82Y20/00 ,  B82Y5/00 ,  A61K41/0057 ,  A61K41/0071 ,  A61K49/0002 ,  A61K49/223 ,  A61K49/226

摘要： 涉及生物医药领域，具体涉及一种造影剂成膜剂组合物、含有该造影剂成膜剂组合物的造影剂成膜脂液，含有该造影剂成膜脂液的造影剂及其制备方法。该造影剂成膜剂组合物包括脂质、乳化剂和表面电荷修饰剂，相对于100重量份的所述脂质，所述乳化剂的含量为20-50重量份，所述表面电荷修饰剂的含量为10-35重量份；其中，所述脂质为羧基化的磷脂，所述表面电荷修饰剂为聚电解质。组合物和制备方法能够使得所得的造影剂的纳米液滴具有更均一的粒径、更高的稳定性和更好的可控性，并且具有更低的超声气化阈值，还能够用作光声造影剂或多模态造影剂，具有广阔的应用前景。