公开(公告)号：WO2008022206A2

公开(公告)日：2008-02-21

申请号：PCT/US2007076017

申请日：2007-08-15

Applicant: MOTIONBACK LLC ,  OCHOA JORGE ALEXANDER ,  HEWKO BRIAN

Inventor： OCHOA JORGE ALEXANDER ,  HEWKO BRIAN

IPC: A61F2/44

CPC classification number: A61F2/442 ,  A61F2/30742 ,  A61F2/4455 ,  A61F2002/30092 ,  A61F2002/3013 ,  A61F2002/30136 ,  A61F2002/30138 ,  A61F2002/30153 ,  A61F2002/30179 ,  A61F2002/30273 ,  A61F2002/30476 ,  A61F2002/30505 ,  A61F2002/30565 ,  A61F2002/30571 ,  A61F2002/30604 ,  A61F2002/30607 ,  A61F2002/30616 ,  A61F2002/30772 ,  A61F2002/30841 ,  A61F2002/30904 ,  A61F2002/3092 ,  A61F2210/0014 ,  A61F2220/0025 ,  A61F2230/0004 ,  A61F2230/001 ,  A61F2230/0017 ,  A61F2230/0019 ,  A61F2230/0058 ,  A61F2230/0086 ,  A61F2250/0062 ,  A61F2310/00796

Abstract: An intervertebral disc prosthesis for installation in a spinal column between upper and lower vertebral surfaces includes a first intervertebral plate and a second intervertebral plate. The first intervertebral plate engages the upper vertebral surface. The second intervertebral plate engages the tower vertebral surface. A nonelastomeric resilient body is installed between and engages said intervertebral plates. The nonelastomeric resilient body comprises a plurality of deformable plates and permits relative movement between the first intervertebral plate and the second intervertebral plate.

Abstract translation: 用于安装在上下椎骨表面之间的脊柱中的椎间盘假体包括第一椎间板和第二椎间盘。 第一椎间板与上椎体表面接合。 第二椎间板与椎体椎体表面接合。 非弹性弹性体安装在所述椎间板之间并与所述椎间板接合。 非弹性体弹性体包括多个可变形板，并且允许第一椎间板和第二椎间板之间的相对运动。

公开(公告)号：WO2006055186A3

公开(公告)日：2006-10-19

申请号：PCT/US2005038335

申请日：2005-10-24

Applicant: ARCHUS ORTHOPEDICS INC ,  KUIPER MARK K ,  YAGER DAVID ,  TOKISH LEONARD JR ,  ROSLER DAVID MICHAEL ,  REILEY MARK A ,  FUNK MICHAEL J ,  OCHOA JORGE ,  ROGERS SUSAN L ,  RALPH CHRISTOPHER ,  CHARBONNEAU MARK ,  BROMAN RICHARD ,  STINSON DAVID ,  MCLEER TOM

Inventor： KUIPER MARK K ,  YAGER DAVID ,  TOKISH LEONARD JR ,  ROSLER DAVID MICHAEL ,  REILEY MARK A ,  FUNK MICHAEL J ,  OCHOA JORGE ,  ROGERS SUSAN L ,  RALPH CHRISTOPHER ,  CHARBONNEAU MARK ,  BROMAN RICHARD ,  STINSON DAVID ,  MCLEER TOM

IPC: A61F2/44 ,  A61B17/15 ,  A61B17/58 ,  A61B17/70 ,  A61F2/00 ,  A61F2/02 ,  A61F2/30 ,  A61F2/46

CPC classification number: A61F2/4405 ,  A61B17/15 ,  A61B17/7064 ,  A61B90/39 ,  A61F2/30742 ,  A61F2/442 ,  A61F2/4455 ,  A61F2002/30331 ,  A61F2002/30405 ,  A61F2002/30462 ,  A61F2002/30507 ,  A61F2002/30537 ,  A61F2002/30538 ,  A61F2002/3055 ,  A61F2002/30563 ,  A61F2002/30566 ,  A61F2002/30601 ,  A61F2002/30604 ,  A61F2002/30607 ,  A61F2002/30617 ,  A61F2002/30682 ,  A61F2002/3069 ,  A61F2002/30841 ,  A61F2002/3085 ,  A61F2002/30878 ,  A61F2002/30884 ,  A61F2002/4631 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2250/0004 ,  A61F2250/0006 ,  A61F2250/0007 ,  A61F2250/0062 ,  A61F2250/0097

Abstract: An adaptable spinal facet joint prosthesis, including a pedicle fixation element; a laminar fixation element; d a facet joint bearing surface having a location adaptable with respect at least one of the pedicle fixation element d the laminar fixation element. Also disclosed is a method of implanting an adaptable spinal facet joint asthesis including the steps of determining a desired position for a facet joint bearing surface; and attaching a prosthesis comprising a facet joint bearing surface to a pedicle portion of a vertebra and a lamina portion of a vertebra to place the facet joint bearing surface in the desired position. The invention also provides a facet joint prosthesis implant tool including a tool guide adapted to guide a vertebra cutting tool; and first and second fixation le alignment elements extending from the saw guide. The invention also provides systems for treating spinal pathologies that include intervertebral discs in combination with spinal and facet joint prostheses.

Abstract translation: 适应性脊柱小关节假体，包括椎弓根固定元件; 层状固定元件; d小面关节轴承表面，其具有适于相对于椎弓根固定元件d层压固定元件中的至少一个的位置。 还公开了一种植入适应性脊柱小关节假体的方法，包括以下步骤：确定小关节支承表面的期望位置; 以及将包括小关节支承表面的假体附接到椎骨的椎弓根部分和椎骨的椎板部分以将小关节支承表面放置在期望的位置。 本发明还提供了一种小关节假体植入工具，其包括适于引导椎骨切割工具的工具引导件; 以及从锯导向件延伸的第一和第二固定杆对准元件。 本发明还提供了用于治疗脊柱病变的系统，其包括与脊椎和小关节假体组合的椎间盘。

公开(公告)号：WO2006055186A2

公开(公告)日：2006-05-26

申请号：PCT/US2005/038335

申请日：2005-10-24

Applicant: ARCHUS ORTHOPEDICS, INC. ,  KUIPER, Mark, K. ,  YAGER, David ,  TOKISH, Leonard, Jr. ,  ROSLER, David, Michael ,  REILEY, Mark, A. ,  FUNK, Michael, J. ,  OCHOA, Jorge ,  ROGERS, Susan, L. ,  RALPH, Christopher ,  CHARBONNEAU, Mark ,  BROMAN, Richard ,  STINSON, David ,  McLEER, Tom

Inventor： KUIPER, Mark, K. ,  YAGER, David ,  TOKISH, Leonard, Jr. ,  ROSLER, David, Michael ,  REILEY, Mark, A. ,  FUNK, Michael, J. ,  OCHOA, Jorge ,  ROGERS, Susan, L. ,  RALPH, Christopher ,  CHARBONNEAU, Mark ,  BROMAN, Richard ,  STINSON, David ,  McLEER, Tom

IPC: A61F2/44 ,  A61B17/70

CPC classification number: A61F2/4405 ,  A61B17/15 ,  A61B17/7064 ,  A61B90/39 ,  A61F2/30742 ,  A61F2/442 ,  A61F2/4455 ,  A61F2002/30331 ,  A61F2002/30405 ,  A61F2002/30462 ,  A61F2002/30507 ,  A61F2002/30537 ,  A61F2002/30538 ,  A61F2002/3055 ,  A61F2002/30563 ,  A61F2002/30566 ,  A61F2002/30601 ,  A61F2002/30604 ,  A61F2002/30607 ,  A61F2002/30617 ,  A61F2002/30682 ,  A61F2002/3069 ,  A61F2002/30841 ,  A61F2002/3085 ,  A61F2002/30878 ,  A61F2002/30884 ,  A61F2002/4631 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2250/0004 ,  A61F2250/0006 ,  A61F2250/0007 ,  A61F2250/0062 ,  A61F2250/0097

Abstract: An adaptable spinal facet joint prosthesis, including a pedicle fixation element; a laminar fixation element; d a facet joint bearing surface having a location adaptable with respect at least one of the pedicle fixation element d the laminar fixation element. The invention also includes a method of implanting an adaptable spinal facet joint asthesis including the steps of determining a desired position for a facet joint bearing surface; and attaching a prosthesis comprising a facet joint bearing surface to a pedicle portion of a vertebra and a lamina portion of a vertebra to place the facet joint bearing surface in the desired position. The invention also provides a facet joint prosthesis implant tool including a tool guide adapted to guide a vertebra cutting tool; and first and second fixation le alignment elements extending from the saw guide. The invention also provides systems for treating spinal pathologies that include intervertebral discs in combination with spinal and facet joint prostheses.

Abstract translation: 适应性脊柱小关节假体，包括椎弓根固定元件; 层状固定元件; d小面关节轴承表面，其具有适于相对于椎弓根固定元件d层压固定元件中的至少一个的位置。 本发明还包括植入适应性脊椎小面关节假体的方法，包括以下步骤：确定小关节支承表面的期望位置; 以及将包括小关节支承表面的假体附接到椎骨的椎弓根部分和椎骨的椎板部分以将小关节支承表面放置在期望的位置。 本发明还提供了一种小关节假体植入工具，其包括适于引导椎骨切割工具的工具引导件; 以及从锯导向件延伸的第一和第二固定杆对准元件。 本发明还提供了用于治疗脊柱病变的系统，其包括与脊椎和小关节假体组合的椎间盘。

公开(公告)号：WO2006055186A8

公开(公告)日：2006-08-31

申请号：PCT/US2005038335

申请日：2005-10-24

Applicant: ARCHUS ORTHOPEDICS INC ,  KUIPER MARK K ,  YAGER DAVID ,  TOKISH LEONARD JR ,  ROSLER DAVID MICHAEL ,  REILEY MARK A ,  FUNK MICHAEL J ,  OCHOA JORGE ,  ROGERS SUSAN L ,  RALPH CHRISTOPHER ,  CHARBONNEAU MARK ,  BROMAN RICHARD ,  STINSON DAVID ,  MCLEER TOM

Inventor： KUIPER MARK K ,  YAGER DAVID ,  TOKISH LEONARD JR ,  ROSLER DAVID MICHAEL ,  REILEY MARK A ,  FUNK MICHAEL J ,  OCHOA JORGE ,  ROGERS SUSAN L ,  RALPH CHRISTOPHER ,  CHARBONNEAU MARK ,  BROMAN RICHARD ,  STINSON DAVID ,  MCLEER TOM

IPC: A61F2/44 ,  A61B17/15 ,  A61B17/58 ,  A61B17/70 ,  A61F2/00 ,  A61F2/02 ,  A61F2/30 ,  A61F2/46

CPC classification number: A61F2/4405 ,  A61B17/15 ,  A61B17/7064 ,  A61B90/39 ,  A61F2/30742 ,  A61F2/442 ,  A61F2/4455 ,  A61F2002/30331 ,  A61F2002/30405 ,  A61F2002/30462 ,  A61F2002/30507 ,  A61F2002/30537 ,  A61F2002/30538 ,  A61F2002/3055 ,  A61F2002/30563 ,  A61F2002/30566 ,  A61F2002/30601 ,  A61F2002/30604 ,  A61F2002/30607 ,  A61F2002/30617 ,  A61F2002/30682 ,  A61F2002/3069 ,  A61F2002/30841 ,  A61F2002/3085 ,  A61F2002/30878 ,  A61F2002/30884 ,  A61F2002/4631 ,  A61F2220/0025 ,  A61F2220/0033 ,  A61F2220/0075 ,  A61F2250/0004 ,  A61F2250/0006 ,  A61F2250/0007 ,  A61F2250/0062 ,  A61F2250/0097

Abstract: An adaptable spinal facet joint prosthesis, including a pedicle fixation element; a laminar fixation element; d a facet joint bearing surface having a location adaptable with respect at least one of the pedicle fixation element d the laminar fixation element. The invention also includes a method of implanting an adaptable spinal facet joint asthesis including the steps of determining a desired position for a facet joint bearing surface; and attaching a prosthesis comprising a facet joint bearing surface to a pedicle portion of a vertebra and a lamina portion of a vertebra to place the facet joint bearing surface in the desired position. The invention also provides a facet joint prosthesis implant tool including a tool guide adapted to guide a vertebra cutting tool; and first and second fixation le alignment elements extending from the saw guide. The invention also provides systems for treating spinal pathologies that include intervertebral discs in combination with spinal and facet joint prostheses.

Abstract translation: 适应性脊柱小关节假体，包括椎弓根固定元件; 层状固定元件; d小面关节轴承表面，其具有适于相对于椎弓根固定元件d层压固定元件中的至少一个的位置。 本发明还包括植入适应性脊椎小面关节假体的方法，包括以下步骤：确定小关节支承表面的期望位置; 以及将包括小关节支承表面的假体附接到椎骨的椎弓根部分和椎骨的椎板部分以将小关节支承表面放置在期望的位置。 本发明还提供了一种小关节假体植入工具，其包括适于引导椎骨切割工具的工具引导件; 以及从锯导向件延伸的第一和第二固定杆对准元件。 本发明还提供了用于治疗脊柱病变的系统，其包括与脊椎和小关节假体组合的椎间盘。

公开(公告)号：WO2012171990A1

公开(公告)日：2012-12-20

申请号：PCT/EP2012/061270

申请日：2012-06-14

Applicant: PROGENIKA BIOPHARMA, S.A. ,  OCHOA, Jorge ,  LÓPEZ, Mónica ,  ESCORZA, Sergio ,  TEJEDOR, Diego ,  MARTÍNEZ, Antonio ,  SIMÓN, Laureano

Inventor： OCHOA, Jorge ,  LÓPEZ, Mónica ,  ESCORZA, Sergio ,  TEJEDOR, Diego ,  MARTÍNEZ, Antonio ,  SIMÓN, Laureano

IPC: C12Q1/68

CPC classification number: C12Q1/6881 ,  C12Q2600/156 ,  C12Q2600/16 ,  C12Q2600/172

Abstract: The present invention provides a method for detecting the presence or absence of, or for discriminating between, blood type variants, including RHD*r's, RHD*DIIIa, RHD*DIVa-2, RHCE*cs s and RHCE*ce733G. The method comprises genotyping a sample obtained from a human subject at one or more positions in intron 7 of the RHD gene and/or in intron 7 of the RHCE gene. The invention also provides products, in particular, probes, primers and kits for use in the method of the invention.

Abstract translation: 本发明提供一种用于检测血液型变体（包括RHD * r，RHD * DIIIa，RHD * DIVa-2，RHCE * css和RHCE * ce733G）的存在或不存在或鉴别的方法。 该方法包括在RHD基因的内含子7和/或RHCE基因的内含子7中的一个或多个位置从人受试者获得的样品基因分型。 本发明还提供了产品，特别是用于本发明方法的探针，底漆和试剂盒。

公开(公告)号：WO2008022206A3

公开(公告)日：2008-02-21

申请号：PCT/US2007/076017

申请日：2007-08-15

Applicant: MOTIONBACK LLC ,  OCHOA, Jorge, Alexander ,  HEWKO, Brian

Inventor： OCHOA, Jorge, Alexander ,  HEWKO, Brian

IPC: A61F2/44

Abstract: An intervertebral disc prosthesis for installation in a spinal column between upper and lower vertebral surfaces includes a first intervertebral plate and a second intervertebral plate. The first intervertebral plate engages the upper vertebral surface. The second intervertebral plate engages the tower vertebral surface. A nonelastomeric resilient body is installed between and engages said intervertebral plates. The nonelastomeric resilient body comprises a plurality of deformable plates and permits relative movement between the first intervertebral plate and the second intervertebral plate.