公开(公告)号：WO2010127115A1

公开(公告)日：2010-11-04

申请号：PCT/US2010/032966

申请日：2010-04-29

Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS LAUSANNE (CHUV) ,  PANTALEO, Giuseppe ,  CALANDRA, Thierry ,  HARARI, Alexandre ,  ROGER, Thierry ,  CENTRO NACIONAL DE BIOTECNOLOGIA (CSIC) ,  ESTEBAN, Mario ,  ARIZONA STATE UNIVERSITY ,  JACOBS, Bertram ,  KIBLER, Karen ,  ACADEMISCH ZIEKENHUIS LEIDEN ALSO ACTING UNDER THE NAME LEIDEN UNIVERSITY MEDICAL CENTER (LUMC) ,  MELIEF, Cornelius ,  UNIVERSITY OF MONTREAL ,  SEKALY, Rafick-Pierre ,  HADDAD, Elias ,  SANOFI PASTEUR LTD. ,  TARTAGLIA, James

Inventor： PANTALEO, Giuseppe ,  CALANDRA, Thierry ,  HARARI, Alexandre ,  ROGER, Thierry ,  ESTEBAN, Mario ,  JACOBS, Bertram ,  KIBLER, Karen ,  MELIEF, Cornelius ,  SEKALY, Rafick-Pierre ,  HADDAD, Elias ,  TARTAGLIA, James

IPC: C12N15/863

CPC classification number: C12N15/86 ,  A61K2039/5256 ,  C12N2710/24143

Abstract: The disclosure relates to recombinant vectors and methods for using the same. In certain embodiments, the recombinant vectors are immunogenic.

Abstract translation: 本公开涉及重组载体及其使用方法。 在某些实施方案中，重组载体是免疫原性的。

公开(公告)号：WO2016063251A1

公开(公告)日：2016-04-28

申请号：PCT/IB2015/058168

申请日：2015-10-22

Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS ,  PANTALEO, Giuseppe ,  PERREAU, Matthieu

Inventor： PANTALEO, Giuseppe ,  PERREAU, Matthieu

IPC: A61K31/167 ,  A61K31/27 ,  A61K31/352 ,  A61K31/505 ,  G01N33/50 ,  A61P31/18

CPC classification number: A61K31/27 ,  A61K31/167 ,  A61K31/18 ,  A61K31/4045 ,  G01N33/505 ,  G01N2333/16 ,  G01N2333/70514

Abstract: This disclosure relates to reagents and methods for reactivating HIV replication in vitro and in vivo.

Abstract translation: 本公开涉及在体外和体内重新激活HIV复制的试剂和方法。

公开(公告)号：WO2012085652A2

公开(公告)日：2012-06-28

申请号：PCT/IB2011/003145

申请日：2011-12-22

Applicant: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS ,  PANTALEO, Giuseppe ,  HARARI, Alexandre ,  PERREAU, Matthieu

Inventor： PANTALEO, Giuseppe ,  HARARI, Alexandre ,  PERREAU, Matthieu

IPC: G01N33/569

CPC classification number: G01N33/5695 ,  G01N33/6863 ,  G01N2333/35 ,  G01N2333/525 ,  G01N2333/55 ,  G01N2333/57

Abstract: This disclosure relates to methods for differentiating between mammals having active and latent Tuberculosis disease.

Abstract translation: 本公开涉及用于区分具有活性和潜伏性结核病的哺乳动物的方法。

公开(公告)号：WO2012085652A3

公开(公告)日：2012-11-22

申请号：PCT/IB2011003145

申请日：2011-12-22

Applicant: CT HOSPITALIER UNIVERSITAIRE VAUDOIS ,  PANTALEO GIUSEPPE ,  HARARI ALEXANDRE ,  PERREAU MATTHIEU

Inventor： PANTALEO GIUSEPPE ,  HARARI ALEXANDRE ,  PERREAU MATTHIEU

IPC: C12Q1/68 ,  G01N33/569

CPC classification number: G01N33/5695 ,  G01N33/6863 ,  G01N2333/35 ,  G01N2333/525 ,  G01N2333/55 ,  G01N2333/57

Abstract: This disclosure relates to methods for differentiating between mammals having active and latent Tuberculosis disease, by determining the percentage of polyfunctional CD4+ T- cells expressing TNF- alpha, IFN- gamma, and IL-2, or by determining expression of IL-17.

Abstract translation: 本公开涉及通过确定表达TNF-α，IFN-γ和IL-2的多功能CD4 + T细胞的百分比或通过测定IL-17的表达来区分具有活性和潜伏性结核病的哺乳动物的方法。