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    CORE ELEMENTS FOR POINT OF CARE DIAGNOSIS OF TUBERCULOSIS
    3.
    发明申请
    CORE ELEMENTS FOR POINT OF CARE DIAGNOSIS OF TUBERCULOSIS 审中-公开
    结核病诊断点的核心要素

    公开(公告)号：WO2017077493A1

    公开(公告)日：2017-05-11

    申请号：PCT/IB2016/056643

    申请日：2016-11-04

    申请人： UNIVERSITY OF PRETORIA ,  CSIR

    发明人： VERSCHOOR, Jan, Adrianus ,  OKEKE, Ikechukwu, Emmanuel ,  KALOMBO, Lonji ,  LEMMER, Yolandy

    IPC分类号： G01N33/543 ,  G01N33/569

    CPC分类号： G01N33/54346 ,  G01N33/5438 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2469/20 ,  G01N2800/12

    摘要： The invention provides a method of diagnosing tuberculosis by using a novel antibody biomarker capturing vehicle, activating a screen-printed electrode using chemical and mechanical polishing, and immobilising mycolic acid antigen biomarkers on the activated electrode. The novel antibody biomarker capturing vehicle is produced by introducing isolated mycolic acid antigens of tuberculous mycobacterial origin onto an outer surface of a nanoparticle such that the mycolic acid antigens are presented as antibody biomarker capturing agents. The solvent resistant screen-printed electrode is activated by both chemically and mechanically polishing the electrode. The mycolic acid antigens are immobilised on the activated electrode by incubating the activated electrode with a mycolic acid-dimethylformamide solution to allow mycolic acid antigens to adsorb onto the activated electrode.

    摘要翻译： 本发明提供了一种通过使用新型抗体生物标志物捕获媒介物，使用化学和机械抛光活化丝网印刷电极，并将霉菌酸抗原生物标志物固定在活化电极上来诊断结核病的方法。 通过将结核分枝杆菌来源的分离的霉菌酸抗原引入纳米颗粒的外表面来产生新型抗体生物标志物捕获媒介物，使得霉菌酸抗原作为抗体生物标志物捕获剂呈现。 通过化学和机械抛光电极激活耐溶剂丝网印刷电极。 通过将活化的电极与霉菌酸 - 二甲基甲酰胺溶液一起孵育，使分枝菌酸抗原固定在活化电极上，使霉菌酸抗原吸附到活化电极上。

    PEPTIDES OF M. TUBERCULOSIS FOR A SCREENING TEST FOR HIV POSITIVE PATIENTS AT HIGH-RISK FOR TUBERCULOSIS
    5.
    发明申请
    PEPTIDES OF M. TUBERCULOSIS FOR A SCREENING TEST FOR HIV POSITIVE PATIENTS AT HIGH-RISK FOR TUBERCULOSIS 审中-公开
    艾滋病病毒感染者高危型流行性肺结核患者筛查结核分枝杆菌肽

    公开(公告)号：WO2016161435A1

    公开(公告)日：2016-10-06

    申请号：PCT/US2016/025894

    申请日：2016-04-04

    申请人： NEW YORK UNIVERSITY

    发明人： LAAL, Suman

    IPC分类号： G01N33/53 ,  G01N33/569

    CPC分类号： G01N33/5695 ,  G01N2333/35 ,  G01N2469/10 ,  G01N2800/26 ,  G01N2800/50

    摘要： Provided are peptides suitable for early detection of active M. tuberculosis (Mtb) infection in immunocompromised individuals. The peptides can form complexes with antibodies directed to Mtb antigens MS, MPT51, ESAT6 or CFPIO. Also provided are methods for detected of complexes of the peptides and the antibodies. The presence of complexes aids in predicting risk in immunocompromised individuals of developing active tuberculosis.

    摘要翻译： 提供了适合于在免疫受损个体中早期检测活动性结核分枝杆菌（Mtb）感染的肽。 肽可以与针对Mtb抗原MS，MPT51，ESAT6或CFPIO的抗体形成复合物。 还提供了检测肽和抗体复合物的方法。 复合物的存在有助于预防免疫功能低下的个体发展为活动性结核病的风险。

    RAPID PHENOTYPE TESTS FOR ANTITUBERCULAR DRUG SENSITIVITY AND RESISTANCE
    6.
    发明申请
    RAPID PHENOTYPE TESTS FOR ANTITUBERCULAR DRUG SENSITIVITY AND RESISTANCE 审中-公开
    用于抗真菌药敏感性和耐药性的快速反应试验

    公开(公告)号：WO2015126922A2

    公开(公告)日：2015-08-27

    申请号：PCT/US2015/016349

    申请日：2015-02-18

    申请人： STC. UNM

    发明人： TIMMINS, Graham ,  CHOI, Seong, Won ,  SILKS, Louis, Pete A.

    IPC分类号： G01N33/532

    CPC分类号： G01N33/58 ,  A61K49/0004 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2458/15 ,  G01N2800/52

    摘要： In one embodiment, the invention provides methods of identifying the sensitivity and resistance to therapeutic drug regimens in a subject who suffers from, or who is suspected of suffering from, a Mycobacterium infection, the method comprising administering (1) isotopically labeled Pretomanid and/or Delaminid, or (2) isotopically labeled ethionamide and/or prothionamide, or (3) isotopically labeled pyrazinamide, or (4) isotopically-labeled isoniazid to the subject and thereafter measuring levels in a subject-derived sample of one or more isotopically-labeled markers corresponding to Mycobacterium-actiwated drug metabolites or degradation products, wherein the absence of detectable levels of Mycobacterium-activated drug metabolites or degradation products indicates either that the subject does not suffer from a Mycobacterium infection or suffers from a Mycobacterium infection which is resistant to treatment with the administered drug regimen.

    摘要翻译： 在一个实施方案中，本发明提供鉴定患有或疑似患有分枝杆菌感染的受试者的治疗药物方案的敏感性和抗性的方法，所述方法包括施用（1）同位素标记的假单胞菌素和/或 （2）同位素标记的乙硫氨酰胺和/或丙硫氨酰胺，或（3）同位素标记的吡嗪酰胺或（4）同位素标记的异烟肼，然后测定受试者衍生的样品中一种或多种同位素标记 对应于分枝杆菌活化的药物代谢物或降解产物的标记，其中不存在可检测水平的分枝杆菌激活的药物代谢物或降解产物表明受试者不患有分枝杆菌感染或遭受耐受治疗的分枝杆菌感染 与施用的药物方案。

    METHODS AND COMPOSITIONS FOR DETECTING TUBERCULOSIS
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR DETECTING TUBERCULOSIS 审中-公开
    检测TUBCCOSOSIS的方法和组合物

    公开(公告)号：WO2014085713A1

    公开(公告)日：2014-06-05

    申请号：PCT/US2013/072416

    申请日：2013-11-27

    申请人： THE METHODIST HOSPITAL RESEARCH INSTITUTE

    发明人： HU, Ye ,  MA, Xin ,  WU, Hung-Jen ,  FAN, Jia ,  SUN, Tong

    IPC分类号： G01N33/543 ,  G01N33/552

    CPC分类号： G01N33/5695 ,  G01N33/552 ,  G01N33/569 ,  G01N2333/35 ,  G01N2469/10

    摘要： Improved methods for detecting active tuberculosis are disclosed. A method comprises enriching at least one M. tuberculosis- specific biomolecule from a sample by contacting the sample with a nanoporous film; and detecting the presence of the M. tuberculosis-specific biomolecule or fragment(s) thereof. The method may further comprise digesting the enriched M. tuberculosis -specific biomolecule with an enzyme to produce a digestion product comprising at least one fragment of the M. tuberculosis -specific biomolecule. Improved sensitivity and speed achieved.

    摘要翻译： 公开了用于检测活动性结核病的改进方法。 一种方法包括通过使样品与纳米孔膜接触来从样品中富集至少一种结核分枝杆菌特异性生物分子; 并检测结核分枝杆菌特异性生物分子或其片段的存在。 该方法还可以包括用酶消化富集的结核分枝杆菌特异性生物分子，以产生包含结核分枝杆菌特异性生物分子的至少一个片段的消化产物。 提高灵敏度和速度。

    STATUS OF TUBERCULOSIS INFECTION IN AN INDIVIDUAL
    9.
    发明申请
    STATUS OF TUBERCULOSIS INFECTION IN AN INDIVIDUAL 审中-公开
    个体血管感染状况

    公开(公告)号：WO2014012928A1

    公开(公告)日：2014-01-23

    申请号：PCT/EP2013/065002

    申请日：2013-07-16

    申请人： LIONEX GMBH

    发明人： SINGH, Mahavir ,  DELIOS, Mario M. ,  DELLA BELLA, Chiara

    IPC分类号： G01N33/569

    CPC分类号： G01N33/6863 ,  G01N2333/35 ,  G01N2333/55 ,  G01N2333/90616

    摘要： In a first aspect, the present invention relates to a method for diagnosing or determining the status of tuberculosis infection in an individual afflicted with or suspected to be afflicted with tuberculosis infection. In a further aspect, a method for the stratification of the therapeutic regimen of an individual with tuberculosis infection is provided as well as a method for predicting a clinical outcome or determining treatment course in an individual afflicted with tuberculosis infection. Moreover, the present invention provides a method for monitoring the change from latent into active status of tuberculosis infection or vice versa in an individual. Furthermore, the present invention relates to a kit for use in diagnosing or detecting the status of tuberculosis infection as well as to Mycobacterium tuberculosis alanine dehydrogenase for use in specifically differentiating latent status from active diseases status of tuberculosis in an individual.

    摘要翻译： 在第一方面，本发明涉及一种诊断或确定患有或怀疑患有结核感染的个体的结核病感染状况的方法。 另一方面，提供了一种用于结核病感染个体的治疗方案分层的方法，以及用于预测患有结核病感染的个体的临床结果或确定治疗过程的方法。 此外，本发明提供了一种用于监测个体中结核病感染的潜伏状态到活动状态的变化或反之亦然的方法。 此外，本发明涉及用于诊断或检测结核病感染状况以及结核分枝杆菌丙氨酸脱氢酶的试剂盒，用于特异性区分潜在状态与个体中结核病的活动性疾病状态。

    A LIPOSOMAL COMPOSITION COMPRISING A STEROL-MODIFIED LIPID AND A PURIFIED MYCOBACTERIAL LIPID CELL WALL COMPONENT AND IT'S USE IN THE DIAGNOSIS OF TUBERCULOSIS
    10.
    发明申请
    A LIPOSOMAL COMPOSITION COMPRISING A STEROL-MODIFIED LIPID AND A PURIFIED MYCOBACTERIAL LIPID CELL WALL COMPONENT AND IT'S USE IN THE DIAGNOSIS OF TUBERCULOSIS 审中-公开
    包含固定化脂质和纯化的脂肪细胞脂肪细胞壁组分的脂质组合物及其用于治疗结核病的诊断

    公开(公告)号：WO2013186679A1

    公开(公告)日：2013-12-19

    申请号：PCT/IB2013/054686

    申请日：2013-06-07

    申请人： UNIVERSITY OF PRETORIA

    发明人： BAUMEISTER, Carl ,  SHAW, Walter, Allen ,  VERSCHOOR, Jan, Adrianus

    IPC分类号： G01N33/543 ,  A61K8/63

    CPC分类号： G01N33/5695 ,  G01N1/38 ,  G01N33/5432 ,  G01N33/92 ,  G01N2333/35 ,  G01N2469/20 ,  G01N2800/12

    摘要： A liposomal composition comprising a sterol-modified lipid and a purified mycobacterial lipid cell wall component or analog or derivative thereof is described. The composition is useful as a lipid antigen-presenting vehicle for the detection of lipid antigen specific biomarker antibodies in antibody containing biological samples in the diagnosis of active tuberculosis. The purified lipid cell wall component is typically a purified mycolic acid or a mixture of mycolic acids from a mycobacterium that produces mycolic acids. The sterol-modified lipid is typically a phospholipid.

    摘要翻译： 描述了包含固醇修饰的脂质和纯化的分枝杆菌脂质细胞壁组分或其类似物或衍生物的脂质体组合物。 该组合物可用作在用于诊断活动性结核病的抗体含有生物样品中的脂质抗原特异性生物标志物抗体的脂质抗原呈递载体。 纯化的脂质细胞壁组分通常是纯化的霉菌酸或来自分枝杆菌的霉菌酸的混合物，其产生霉菌酸。 甾醇修饰的脂质通常是磷脂。