公开(公告)号：WO2008049087A3

公开(公告)日：2008-04-24

申请号：PCT/US2007/081853

申请日：2007-10-18

Applicant: MINNOW MEDICAL, INC. ,  STONE, Corbett, W. ,  HOEY, Michael, F. ,  BLANCK, Arthur, G. ,  BRIGGS, Len ,  PERRY, Mike ,  GUSTUS, Rolfe, Tyson

Inventor： STONE, Corbett, W. ,  HOEY, Michael, F. ,  BLANCK, Arthur, G. ,  BRIGGS, Len ,  PERRY, Mike ,  GUSTUS, Rolfe, Tyson

IPC: A61B18/04

Abstract: A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engages tissue including diseased tissue when the structure expands.

公开(公告)号：WO2008049087A2

公开(公告)日：2008-04-24

申请号：PCT/US2007081853

申请日：2007-10-18

Applicant: MINNOW MEDICAL INC ,  STONE CORBETT W ,  HOEY MICHAEL F ,  BLANCK ARTHUR G ,  BRIGGS LEN ,  PERRY MIKE ,  GUSTUS ROLFE TYSON

Inventor： STONE CORBETT W ,  HOEY MICHAEL F ,  BLANCK ARTHUR G ,  BRIGGS LEN ,  PERRY MIKE ,  GUSTUS ROLFE TYSON

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00702 ,  A61B2018/00875

Abstract: A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engages tissue including diseased tissue when the structure expands.

Abstract translation: 导管和导管系统可用于通过温和加热结合轻度或标准扩张来治疗疾病组织。 当结构膨胀时，具有多个电极的具有径向可膨胀气囊的细长柔性导管体接合包括患病组织的组织。

公开(公告)号：WO2010132703A1

公开(公告)日：2010-11-18

申请号：PCT/US2010/034789

申请日：2010-05-13

Applicant: MINNOW MEDICAL, INC ,  PERRY, Mike ,  CONN, Brian, D. ,  GUSTUS, Rolfe, T. ,  SCHREIBER, Ronda ,  STONE, Corbett ,  HOEY, Michael, F.

Inventor： PERRY, Mike ,  CONN, Brian, D. ,  GUSTUS, Rolfe, T. ,  SCHREIBER, Ronda ,  STONE, Corbett ,  HOEY, Michael, F.

IPC: A61N1/30

CPC classification number: A61B18/1492 ,  A61B18/1815 ,  A61B18/24 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022

Abstract: Systems and methods are disclosed for the treatment of a target tissue by directionally delivering energy and/or bioactive materials to achieve a therapeutic effect. A balloon catheter system having a balloon portion and a plurality of electrodes may be energized to selectively deliver energy, bioactive materials, or a combination thereof to target tissue including tissues disposed about a lumen. The tissue may be targeted by applying energy, making tissue impedance analysis, and further selectively energizing electrodes through the use of an energy source with a controller.

Abstract translation: 公开了用于通过定向递送能量和/或生物活性材料以实现治疗效果来治疗靶组织的系统和方法。 具有球囊部分和多个电极的球囊导管系统可被激励以选择性地将能量，生物活性材料或其组合输送到包括围绕管腔设置的组织的靶组织。 通过施加能量，进行组织阻抗分析以及通过使用能量源与控制器进一步选择性地激励电极，可以对组织进行靶向。

公开(公告)号：WO2010057043A1

公开(公告)日：2010-05-20

申请号：PCT/US2009/064465

申请日：2009-11-13

Applicant: MINNOW MEDICAL, INC. ,  PERRY, Mike ,  STONE, Corbett W. ,  GUSTUS, Rolfe Tyson ,  SCHREIBER, Ronda ,  MAZOR, Meital ,  CONN, Brian

Inventor： PERRY, Mike ,  STONE, Corbett W. ,  GUSTUS, Rolfe Tyson ,  SCHREIBER, Ronda ,  MAZOR, Meital ,  CONN, Brian

IPC: A61M31/00

CPC classification number: A61M25/10 ,  A61B5/053 ,  A61B5/6853 ,  A61B18/1492 ,  A61B18/24 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00898 ,  A61B2018/1861 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/45 ,  A61L2300/606 ,  A61M25/104 ,  A61M37/0092 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1088 ,  A61N7/022

Abstract: Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.

Abstract translation: 公开了用于通过涂层或流体输送通道在腔中选择性药物或流体递送的方法和系统。 一个系统包括细长导管，其具有近端和远端，其间具有轴线，导管具有靠近远端的径向可扩张的气囊，靠近球囊的能量传递部分用于传递能量;热可变涂层，具有可释放的 联接到气囊的药物，当可膨胀气囊膨胀时，热可变涂层被定向为抵靠身体组织，并且能量源可操作地联接到能量输送部分，其被配置为激发能量输送部分以加热和液化热变性涂层 将药物释放到身体组织。

公开(公告)号：WO2010033940A1

公开(公告)日：2010-03-25

申请号：PCT/US2009/057728

申请日：2009-09-21

Applicant: MINNOW MEDICAL, INC ,  GUSTUS, Rolfe Tyson ,  STONE, Corbett W. ,  HOEY, Michael F. ,  BLANCK, Arthur G. ,  BRIGGS, Len ,  PERRY, Mike ,  MAZOR, Meital ,  KUNSTMANAS, Linas R.

Inventor： GUSTUS, Rolfe Tyson ,  STONE, Corbett W. ,  HOEY, Michael F. ,  BLANCK, Arthur G. ,  BRIGGS, Len ,  PERRY, Mike ,  MAZOR, Meital ,  KUNSTMANAS, Linas R.

IPC: A61B17/00

CPC classification number: A61B18/245 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/055 ,  A61B8/12 ,  A61B17/2202 ,  A61B18/18 ,  A61B2017/00057 ,  A61B2018/00642 ,  A61B2018/2272 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0078

Abstract: A system for inducing desirable temperature effects on body tissue, the body tissue being disposed about a lumen. The system includes an elongate catheter having a proximal end and a distal end with an axis therebetween with an energy delivery portion for transmission of energy. A tissue analyzer configured to characterize the body tissue in the lumen proximate the energy delivery portion and an energy source coupled to the energy delivery portion transmitting tissue treatment energy, wherein the energy is non-RF energy. A processor coupled to the tissue analyzer and energy source, the processor configured to determine an appropriate treatment energy for the characterized body tissue so as to mildly heat the body tissue with the energy delivery portion without ablating.

Abstract translation: 一种用于在身体组织上诱导期望的温度效应的系统，所述身体组织围绕内腔设置。 该系统包括细长导管，其具有近端和远端，其间具有用于传输能量的能量传递部分的轴线。 组织分析器，被配置为表征靠近能量传递部分的内腔中的身体组织，以及耦合到传送组织处理能量的能量传递部分的能量源，其中能量是非RF能量。 耦合到组织分析器和能量源的处理器，所述处理器被配置为确定所述特征的身体组织的适当的治疗能量，以便在不消融的情况下用能量输送部分轻度地加热身体组织。

公开(公告)号：WO2008049082A3

公开(公告)日：2008-06-05

申请号：PCT/US2007081845

申请日：2007-10-18

Applicant: MINNOW MEDICAL INC ,  STONE CORBETT W ,  HOEY MICHAEL F ,  GUSTUS ROLFE TYSON ,  PERRY MIKE ,  BLANCK ARTHUR G ,  KUNSTMANAS LINAS R

Inventor： STONE CORBETT W ,  HOEY MICHAEL F ,  GUSTUS ROLFE TYSON ,  PERRY MIKE ,  BLANCK ARTHUR G ,  KUNSTMANAS LINAS R

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/1467

Abstract: Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

Abstract translation: 公开了通过温和加热来治疗患病组织的方法和系统。 该方法诱导围绕具有健康组织和患病组织的管腔布置的组织上的血管舒张。 该方法包括将探针表面耦合到目标位置处的腔组织，并将期望量的组织重构能量从耦合的探针传送到腔组织中的多个离散重塑区中的每一个中，使得组织重塑能量加热多个 重塑区域，重塑能量被配置成避免肌肉收缩并抑制急性和长期的管腔闭塞。

公开(公告)号：WO2004084195A1

公开(公告)日：2004-09-30

申请号：PCT/GB2004/000999

申请日：2004-03-11

Applicant: NANOMAGNETICS LTD ,  PERRY, Mike ,  HOINVILLE, Jay ,  HOULIHAN, James, M. ,  NARTOWSKI, Artur ,  MAYES, Eric

Inventor： PERRY, Mike ,  HOINVILLE, Jay ,  HOULIHAN, James, M. ,  NARTOWSKI, Artur ,  MAYES, Eric

IPC: G11B5/842

CPC classification number: B82Y25/00 ,  G11B5/712 ,  G11B5/842 ,  H01F1/009 ,  H01F10/005 ,  H01F10/007 ,  H01F41/16

Abstract: A method of forming a magnetic recording device having a film of magnetisable nanoparticles, which comprises preparing a suspension of magnetisable nanoparticles in a carrier fluid and depositing said fluid suspension onto a substrate surface as droplets having a volume less than about 1 nl to form said film of magnetisable nanoparticles as a dry residue of the deposited fluid suspension. The invention also broadly relates to methods of forming magnetisable, inorganic and protein films.

Abstract translation: 一种形成具有可磁化纳米颗粒膜的磁记录装置的方法，其包括在载体流体中制备可磁化纳米颗粒的悬浮液，并将所述流体悬浮液沉积到具有小于约1nl的体积的液滴形成所述膜 的可磁化纳米颗粒作为沉积的流体悬浮液的干燥残余物。 本发明还广泛涉及形成可磁化，无机和蛋白质膜的方法。

公开(公告)号：WO2008049082A2

公开(公告)日：2008-04-24

申请号：PCT/US2007/081845

申请日：2007-10-18

Applicant: MINNOW MEDICAL, INC. ,  STONE, Corbett W. ,  HOEY, Michael F. ,  GUSTUS, Rolfe Tyson ,  PERRY, Mike ,  BLANCK, Arthur G. ,  KUNSTMANAS, Linas R.

Inventor： STONE, Corbett W. ,  HOEY, Michael F. ,  GUSTUS, Rolfe Tyson ,  PERRY, Mike ,  BLANCK, Arthur G. ,  KUNSTMANAS, Linas R.

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/1467

Abstract: Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

Abstract translation: 公开了通过温和加热来治疗患病组织的方法和系统。 该方法在围绕具有健康组织和患病组织的内腔的组织上引起血管舒张。 该方法包括将探针表面耦合到目标位置处的管腔组织，并将期望量的组织重建能量从耦合的探针传送到管腔组织中的多个离散重建区域中的每一个中，使得组织重建能量加热多个 重塑区域，重塑能量被配置为避免肌肉收缩并抑制管腔的急性和长期闭塞。