公开(公告)号：WO2011130663A3

公开(公告)日：2013-07-11

申请号：PCT/US2011032730

申请日：2011-04-15

Applicant: ASCENTX MEDICAL INC ,  STONE CORBETT W ,  LEMPERLE STEFAN M ,  ANDERSON RUSSELL J ,  LEMPERLE GOTTFRIED H

Inventor： STONE CORBETT W ,  LEMPERLE STEFAN M ,  ANDERSON RUSSELL J ,  LEMPERLE GOTTFRIED H

IPC: A61M5/315

CPC classification number: A61M5/31511 ,  A61B17/0625 ,  A61M5/3129 ,  A61M5/315 ,  A61M5/46 ,  A61M25/0084 ,  A61M2005/3131 ,  A61M2025/0091

Abstract: An injection device is formed as a long tubular structure with a wire that controls a piston in the structure from a proximal end, allowing therapeutic material to be injected into a patient through a needle at a distal end.

Abstract translation: 注射装置形成为具有从近端控制结构中的活塞的线的长管状结构，允许治疗材料通过远端的针注射到患者体内。

公开(公告)号：WO2010057043A1

公开(公告)日：2010-05-20

申请号：PCT/US2009/064465

申请日：2009-11-13

Applicant: MINNOW MEDICAL, INC. ,  PERRY, Mike ,  STONE, Corbett W. ,  GUSTUS, Rolfe Tyson ,  SCHREIBER, Ronda ,  MAZOR, Meital ,  CONN, Brian

Inventor： PERRY, Mike ,  STONE, Corbett W. ,  GUSTUS, Rolfe Tyson ,  SCHREIBER, Ronda ,  MAZOR, Meital ,  CONN, Brian

IPC: A61M31/00

CPC classification number: A61M25/10 ,  A61B5/053 ,  A61B5/6853 ,  A61B18/1492 ,  A61B18/24 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00898 ,  A61B2018/1861 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/45 ,  A61L2300/606 ,  A61M25/104 ,  A61M37/0092 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1088 ,  A61N7/022

Abstract: Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.

Abstract translation: 公开了用于通过涂层或流体输送通道在腔中选择性药物或流体递送的方法和系统。 一个系统包括细长导管，其具有近端和远端，其间具有轴线，导管具有靠近远端的径向可扩张的气囊，靠近球囊的能量传递部分用于传递能量;热可变涂层，具有可释放的 联接到气囊的药物，当可膨胀气囊膨胀时，热可变涂层被定向为抵靠身体组织，并且能量源可操作地联接到能量输送部分，其被配置为激发能量输送部分以加热和液化热变性涂层 将药物释放到身体组织。

公开(公告)号：WO2010033940A1

公开(公告)日：2010-03-25

申请号：PCT/US2009/057728

申请日：2009-09-21

Applicant: MINNOW MEDICAL, INC ,  GUSTUS, Rolfe Tyson ,  STONE, Corbett W. ,  HOEY, Michael F. ,  BLANCK, Arthur G. ,  BRIGGS, Len ,  PERRY, Mike ,  MAZOR, Meital ,  KUNSTMANAS, Linas R.

Inventor： GUSTUS, Rolfe Tyson ,  STONE, Corbett W. ,  HOEY, Michael F. ,  BLANCK, Arthur G. ,  BRIGGS, Len ,  PERRY, Mike ,  MAZOR, Meital ,  KUNSTMANAS, Linas R.

IPC: A61B17/00

CPC classification number: A61B18/245 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/055 ,  A61B8/12 ,  A61B17/2202 ,  A61B18/18 ,  A61B2017/00057 ,  A61B2018/00642 ,  A61B2018/2272 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0078

Abstract: A system for inducing desirable temperature effects on body tissue, the body tissue being disposed about a lumen. The system includes an elongate catheter having a proximal end and a distal end with an axis therebetween with an energy delivery portion for transmission of energy. A tissue analyzer configured to characterize the body tissue in the lumen proximate the energy delivery portion and an energy source coupled to the energy delivery portion transmitting tissue treatment energy, wherein the energy is non-RF energy. A processor coupled to the tissue analyzer and energy source, the processor configured to determine an appropriate treatment energy for the characterized body tissue so as to mildly heat the body tissue with the energy delivery portion without ablating.

Abstract translation: 一种用于在身体组织上诱导期望的温度效应的系统，所述身体组织围绕内腔设置。 该系统包括细长导管，其具有近端和远端，其间具有用于传输能量的能量传递部分的轴线。 组织分析器，被配置为表征靠近能量传递部分的内腔中的身体组织，以及耦合到传送组织处理能量的能量传递部分的能量源，其中能量是非RF能量。 耦合到组织分析器和能量源的处理器，所述处理器被配置为确定所述特征的身体组织的适当的治疗能量，以便在不消融的情况下用能量输送部分轻度地加热身体组织。

公开(公告)号：WO2008049082A3

公开(公告)日：2008-06-05

申请号：PCT/US2007081845

申请日：2007-10-18

Applicant: MINNOW MEDICAL INC ,  STONE CORBETT W ,  HOEY MICHAEL F ,  GUSTUS ROLFE TYSON ,  PERRY MIKE ,  BLANCK ARTHUR G ,  KUNSTMANAS LINAS R

Inventor： STONE CORBETT W ,  HOEY MICHAEL F ,  GUSTUS ROLFE TYSON ,  PERRY MIKE ,  BLANCK ARTHUR G ,  KUNSTMANAS LINAS R

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/1467

Abstract: Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

Abstract translation: 公开了通过温和加热来治疗患病组织的方法和系统。 该方法诱导围绕具有健康组织和患病组织的管腔布置的组织上的血管舒张。 该方法包括将探针表面耦合到目标位置处的腔组织，并将期望量的组织重构能量从耦合的探针传送到腔组织中的多个离散重塑区中的每一个中，使得组织重塑能量加热多个 重塑区域，重塑能量被配置成避免肌肉收缩并抑制急性和长期的管腔闭塞。

公开(公告)号：WO2005107623A2

公开(公告)日：2005-11-17

申请号：PCT/US2005/015633

申请日：2005-05-04

Applicant: MINNOW MEDICAL, LLC ,  STEINKE, Tom, A. ,  STONE, Corbett, W. ,  MICHEL, Raphael, M.

Inventor： STEINKE, Tom, A. ,  STONE, Corbett, W. ,  MICHEL, Raphael, M.

IPC: A61B18/20

CPC classification number: A61B5/6852 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B18/245 ,  A61B2018/00982 ,  A61B2018/2272 ,  A61B2090/373

Abstract: Devices, systems, and methods for treating atherosclerotic lesions and other disease states, particularly for treatment of vulnerable plaques, can incorporate optical coherence tomography or other imaging techniques which allow a structure and location of an eccentric plaque to be characterized. Remodeling and/or ablative laser energy can then be selectively and automatically directed to the appropriate plaque structures, often without imposing mechanical trauma to the entire circumference of the lumen wall.

Abstract translation: 用于治疗动脉粥样硬化病变和其他疾病状态的装置，系统和方法，特别是用于治疗脆弱斑块的装置，系统和方法可以包括光学相干断层扫描或允许表征偏心斑块的结构和位置的其它成像技术。 然后，重建和/或烧蚀激光能量可以选择性地并且自动地指向适当的斑块结构，通常不会对管腔壁的整个周边造成机械创伤。

公开(公告)号：WO2013067179A3

公开(公告)日：2013-10-17

申请号：PCT/US2012063061

申请日：2012-11-01

Applicant: SYNTHES USA LLC ,  SYNTHES GMBH ,  DEPUY SPINE INC ,  STONE CORBETT W ,  GAMBHIR KABIR ,  ANDERSON TIMOTHY ,  ARNOLD BENJAMIN ,  HEIMAN STEPHEN ,  HARVEY DUSTIN ,  BISHOP ROBERT ,  MAGUIRE PAUL S

Inventor： STONE CORBETT W ,  GAMBHIR KABIR ,  ANDERSON TIMOTHY ,  ARNOLD BENJAMIN ,  HEIMAN STEPHEN ,  HARVEY DUSTIN ,  BISHOP ROBERT ,  MAGUIRE PAUL S

IPC: A61M29/00 ,  A61B17/00 ,  A61B17/02 ,  A61B17/34

CPC classification number: A61B17/0218 ,  A61B5/04001 ,  A61B17/025 ,  A61B17/3439 ,  A61B17/3468 ,  A61B2017/00022 ,  A61B2017/0256 ,  A61B2017/0262

Abstract: A dilation system for accessing a surgical target site to perform surgical procedures. In one version, the dilation system includes a plurality of open sided dilators having non-circular cross sections and configured to slidably and non- rotationally engage with one another in a sequential manner. In another version, the dilation system includes an expandable dilator movable from a closed condition to an expanded condition.

Abstract translation: 用于进入外科手术目标部位进行外科手术的扩张系统。 在一个版本中，扩张系统包括具有非圆形横截面并且被配置为以顺序方式彼此可滑动地且不旋转地接合的多个开口侧扩张器。 在另一个版本中，扩张系统包括可从闭合状态移动到膨胀状态的可扩张扩张器。

公开(公告)号：WO2013067179A2

公开(公告)日：2013-05-10

申请号：PCT/US2012/063061

申请日：2012-11-01

Applicant: SYNTHES USA, LLC ,  SYNTHES, Gmbh ,  DEPUY SPINE, INC. ,  STONE, Corbett, W. ,  GAMBHIR, Kabir ,  ANDERSON, Timothy ,  ARNOLD, Benjamin ,  HEIMAN, Stephen ,  HARVEY, Dustin ,  BISHOP, Robert ,  MAGUIRE, Paul, S.

Inventor： STONE, Corbett, W. ,  GAMBHIR, Kabir ,  ANDERSON, Timothy ,  ARNOLD, Benjamin ,  HEIMAN, Stephen ,  HARVEY, Dustin ,  BISHOP, Robert ,  MAGUIRE, Paul, S.

IPC: A61M29/00

CPC classification number: A61B17/0218 ,  A61B5/04001 ,  A61B17/025 ,  A61B17/3439 ,  A61B17/3468 ,  A61B2017/00022 ,  A61B2017/0256 ,  A61B2017/0262

Abstract: A dilation system for accessing a surgical target site to perform surgical procedures. In one version, the dilation system includes a plurality of open sided dilators having non-circular cross sections and configured to slidably and non- rotationally engage with one another in a sequential manner. In another version, the dilation system includes an expandable dilator movable from a closed condition to an expanded condition.

Abstract translation: 用于进入手术目标部位以执行外科手术的扩张系统。 在一个版本中，扩张系统包括多个具有非圆形横截面的开口侧扩张器，并且被构造成以顺序方式彼此可滑动地且非旋转地接合。 在另一版本中，扩张系统包括一个可从扩张状态移动到扩张状态的可扩张扩张器。

公开(公告)号：WO2008049087A3

公开(公告)日：2008-04-24

申请号：PCT/US2007/081853

申请日：2007-10-18

Applicant: MINNOW MEDICAL, INC. ,  STONE, Corbett, W. ,  HOEY, Michael, F. ,  BLANCK, Arthur, G. ,  BRIGGS, Len ,  PERRY, Mike ,  GUSTUS, Rolfe, Tyson

Inventor： STONE, Corbett, W. ,  HOEY, Michael, F. ,  BLANCK, Arthur, G. ,  BRIGGS, Len ,  PERRY, Mike ,  GUSTUS, Rolfe, Tyson

IPC: A61B18/04

Abstract: A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engages tissue including diseased tissue when the structure expands.

公开(公告)号：WO2008049087A2

公开(公告)日：2008-04-24

申请号：PCT/US2007081853

申请日：2007-10-18

Applicant: MINNOW MEDICAL INC ,  STONE CORBETT W ,  HOEY MICHAEL F ,  BLANCK ARTHUR G ,  BRIGGS LEN ,  PERRY MIKE ,  GUSTUS ROLFE TYSON

Inventor： STONE CORBETT W ,  HOEY MICHAEL F ,  BLANCK ARTHUR G ,  BRIGGS LEN ,  PERRY MIKE ,  GUSTUS ROLFE TYSON

IPC: A61B18/14

CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00702 ,  A61B2018/00875

Abstract: A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engages tissue including diseased tissue when the structure expands.

Abstract translation: 导管和导管系统可用于通过温和加热结合轻度或标准扩张来治疗疾病组织。 当结构膨胀时，具有多个电极的具有径向可膨胀气囊的细长柔性导管体接合包括患病组织的组织。

公开(公告)号：WO2005041748A2

公开(公告)日：2005-05-12

申请号：PCT/US2004/029740

申请日：2004-09-10

Applicant: MINNOW MEDICAL, LLC ,  STEINKE, Tom, A. ,  STONE, Corbett, W. ,  ROSS, Stephen, O. ,  KELLEHER, Brian, S. ,  MICHEL, Raphael, M.

Inventor： STEINKE, Tom, A. ,  STONE, Corbett, W. ,  ROSS, Stephen, O. ,  KELLEHER, Brian, S. ,  MICHEL, Raphael, M.

IPC: A61B

CPC classification number: A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/0041 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00654 ,  A61B2018/1861 ,  A61B2090/373 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/3784 ,  A61B2218/002 ,  A61B2218/007

Abstract: A catheter and catheter system for eccentric remodeling and/or removal of atherosclerotic material of a blood vessel of a patient include an elongate flexible catheter body with a radially expandable structure. A plurality of electrodes or other electrosurgical energy delivery surfaces can radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector near the distal end of the catheter body may measure circumferential atherosclerotic material distribution, and a power source selectively energizes the electrodes to eccentrically remodel the measured atherosclerotic material.

Abstract translation: 用于偏心重塑和/或去除患者血管的动脉粥样硬化材料的导管和导管系统包括具有径向可扩张结构的细长柔性导管体。 当结构膨胀时，多个电极或其它电外科能量输送表面可径向地接合动脉粥样硬化材料。 在导管主体的远端附近的动脉粥样硬化材料检测器可以测量圆周动脉粥样硬化材料分布，并且电源选择性地激励电极以偏心改造测量的动脉粥样硬化材料。