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公开(公告)号：WO2007115929A8
公开(公告)日：2008-06-19
申请号：PCT/EP2007052912
申请日：2007-03-27
Applicant: BOEHRINGER INGELHEIM INT , BOEHRINGER INGELHEIM PHARMA , BRANDL TRIXI , MAIER UDO , HOFFMANN MATTHIAS , SCHEUERER STEFAN , JOERGENSEN ANNE T , PAUTSCH ALEXANDER , BREITFELDER STEFFEN , GRAUERT MATTHIAS , HOENKE CHRISTOPH , ERB KLAUS , PIEPER MICHAEL , PRAGST INGO
Inventor： BRANDL TRIXI , MAIER UDO , HOFFMANN MATTHIAS , SCHEUERER STEFAN , JOERGENSEN ANNE T , PAUTSCH ALEXANDER , BREITFELDER STEFFEN , GRAUERT MATTHIAS , HOENKE CHRISTOPH , ERB KLAUS , PIEPER MICHAEL , PRAGST INGO
IPC: C07D513/04 , A61K31/429 , A61P29/00
CPC classification number: C07D513/04
Abstract: The invention relates to novel thiazolyl-dihydroquinazolines of general formula (I), wherein the groups R 1 to R 4 are defined as in the claims and in the description, and to the isomers thereof. The invention also relates to methods for producing said thiazolyl-dihydroindazoles and to their use as drugs.
Abstract translation: 本发明涉及通式（I）的新的噻唑二氢喹唑啉其中R 1 至R 4 具有权利要求书和说明书中给出的含义，所述 异构体，以及制备这些噻唑基二氢吲唑和它们作为药物的用途。
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2.发明申请
公开(公告)号：WO2007077164A1
公开(公告)日：2007-07-12
申请号：PCT/EP2006/070137
申请日：2006-12-22
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG , PIEPER, Michael, P.
Inventor： PIEPER, Michael, P.
Abstract: The present invention relates to novel pharmaceutical compositions based on anticholinergics and andolast, processes for preparing them a nd their use in the treatment of respiratory diseases.
Abstract translation: 本发明涉及基于抗胆碱能药和安慰剂的新型药物组合物，其制备方法及其在治疗呼吸系统疾病中的应用。
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3.发明申请
公开(公告)号：WO2007042467A1
公开(公告)日：2007-04-19
申请号：PCT/EP2006/067122
申请日：2006-10-06
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , BOUYSSOU, Thierry , PIEPER, Michael, P. , SCHNAPP, Andreas
Inventor： BOUYSSOU, Thierry , PIEPER, Michael, P. , SCHNAPP, Andreas
CPC classification number: A61K31/538 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/124 , A61K31/40 , A61K31/439 , A61K31/46 , A61K45/06 , A61K2300/00
Abstract: Die vorliegende Erfindung betrifft neue Arzneimittelkombinationen, die neben einer oder mehrerer, bevorzugt einer Verbindung der allgemeinen Formel (1), worin die Reste R 1 , R 2 und R 3 die in den Ansprüchen und in der Beschreibung genannten Bedeutungen haben können, wenigstens einen weiteren Wirkstoff 2 enthalten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel.
Abstract translation: 本发明涉及含有在除了一个或多个，上述通式（1）的优选一种化合物，其中基团R的新的药物组合 1 ，R 2 和R 3 可以具有在权利要求和说明书中给出的含义，至少一种其他活性物质2，它们的制备方法和它们作为药物的用途。
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4.发明申请
公开(公告)号：WO2006128847A2
公开(公告)日：2006-12-07
申请号：PCT/EP2006/062683
申请日：2006-05-29
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , PIEPER, Michael, P. , SCHNAPP, Andreas , NICKOLAUS, Peter
Inventor： PIEPER, Michael, P. , SCHNAPP, Andreas , NICKOLAUS, Peter
IPC: A61K31/46 , A61K31/439 , A61K45/06 , A61K31/137 , A61K31/44 , A61P11/06 , A61P15/06 , A61P9/02
CPC classification number: A61K31/46 , A61K31/137 , A61K31/439 , A61K31/44
Abstract: The present invention relates to new medicament combinations which contain in addition to one or more, preferably one, betamimetic 1 , at least one anticholinergic 2 and at least one PDEIV-inhibitor 3 , processes for preparing them and their use as pharmaceutical compositions.
Abstract translation: 本发明涉及除了一种或多种，优选一种β-游离形式1，至少一种抗胆碱能2和至少一种PDEIV抑制剂3外，还包含其中制备它们的方法及其作为药物组合物的用途的新药物组合。
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5.发明申请
公开(公告)号：WO2006087316A1
公开(公告)日：2006-08-24
申请号：PCT/EP2006/050901
申请日：2006-02-13
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , PIEPER, Michael, P.
Inventor： PIEPER, Michael, P.
IPC: A61K31/573 , A61K31/46 , A61P11/06
CPC classification number: A61K45/06 , A61K31/46 , A61K31/4745 , A61K31/573 , A61K2300/00
Abstract: The present invention relates to novel pharmaceutical compositions based on anticholinergics and etiprednol, processes for preparing them and their use in the treatment of respiratory diseases.
Abstract translation: 本发明涉及基于抗胆碱能药和etiprednol的新型药物组合物，其制备方法及其在治疗呼吸系统疾病中的应用。
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Patent Agency Ranking6.发明申请INHALATIVE ARZNEIMITTEL ENTHALTEND EIN ANTICHOLINERGIKUM, SALMETEROL UND EIN STEROID AUS DER GRUPPE CICLESONIDE ODER MOMETASONFUROAT 审中-公开含有抗胆碱能药，沙美特罗和类固醇选自OR环索奈德糠酸莫米松吸入式药物
公开(公告)号：WO2006056527A1
公开(公告)日：2006-06-01
申请号：PCT/EP2005/055783
申请日：2005-11-07
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , PIEPER,, Michael P.
Inventor： PIEPER,, Michael P.
IPC: A61K31/137 , A61K31/58 , A61K31/135
CPC classification number: A61K31/135 , A61K31/137 , A61K31/58 , A61K2300/00
Abstract: Die vorliegende Erfindung betrifft neuartige Arzneimittelkompositionen auf der Basis eines Anticholinergikums, Salmeterolxinafoat und einem Corticosteroid, Ausgewählt aus der Gruppe Ciclesonide oder Mometasonfuroat . Verfahren zu deren Herstellung sowie deren Verwendung bei der Therapie von Atemwegserkrankungen.
Abstract translation: 本发明涉及新的药物组合物抗胆碱能药，沙美特罗羟萘甲酸盐和选自环索奈德或糠酸莫米松的皮质类固醇的基础上。 它们的制备方法和它们在呼吸疾病的治疗中的用途。
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7.发明申请NEW PHARMACEUTICAL COMPOSITIONS BASED ON BENZILIC ACID ESTERS AND SOLUBLE TNF RECEPTOR FUSION PROTEINS 审中-公开基于苯甲酸酯和可溶性TNF受体融合蛋白的新药物组合物
公开(公告)号：WO2005080338A2
公开(公告)日：2005-09-01
申请号：PCT/EP2005/001697
申请日：2005-02-18
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , PAIRET, Michel , MEADE, Christopher, John, Montague , PIEPER, Michael, P.
IPC: C07D211/00
CPC classification number: A61K45/06 , A61K31/439 , A61K38/191 , A61K2300/00
Abstract: The present invention relates to novel pharmaceutical compositions based on benzilic acid ester derived anticholinergics of formula (1) and soluble TNF receptor fusion proteins, processes for preparing them and their use in the treatment of respiratory diseases.
Abstract translation: 本发明涉及基于苯甲酸酯衍生的式（1）抗胆碱能药物和可溶性TNF受体融合蛋白的新型药物组合物，其制备方法及其在治疗呼吸系统疾病中的应用。
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8.发明申请MEDICAMENTS COMPRISING PDE IV INHIBITORS AND A NOVEL ANTICHOLINERGIC AND THEIR USE FOR TREATING RESPIRATORY DISORDERS 审中-公开含有PDE IV抑制剂和新型抗胆碱药物及其用于治疗呼吸道疾病的药物
公开(公告)号：WO2005013967A1
公开(公告)日：2005-02-17
申请号：PCT/EP2004/008003
申请日：2004-07-23
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , GERMEYER, Sabine , MEADE, Christopher, John, Montague , MEISSNER, Helmut , MORSCHHAEUSER, Gerd , PAIRET, Michel , PESTEL, Sabine , PIEPER, Michael, P. , POHL, Gerald , REICHL, Richard , SPECK, Georg
Inventor： GERMEYER, Sabine , MEADE, Christopher, John, Montague , MEISSNER, Helmut , MORSCHHAEUSER, Gerd , PAIRET, Michel , PESTEL, Sabine , PIEPER, Michael, P. , POHL, Gerald , REICHL, Richard , SPECK, Georg
IPC: A61K31/335
CPC classification number: A61K9/0075 , A61K9/0078 , A61K9/008 , A61K31/192 , A61K31/335 , A61K31/4015 , A61K31/44 , A61K31/46 , A61K31/4745 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to novel pharmaceutical compositions based on PDE IV inhibitors and salts of a new anticholinergic, processes for preparing them and their use in the treatment of respiratory complaints.
Abstract translation: 本发明涉及基于PDE IV抑制剂和新的抗胆碱能药物的新型药物组合物，其制备方法及其在治疗呼吸道疾病中的应用。
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9.发明申请NEW PHARMACEUTICAL COMPOSITIONS BASED ON ANTICHOLINERGICS AND INHIBITORS OF TNF ALPHA SYNTHESIS OR ACTION 审中-公开基于抗肿瘤药物和TNF ALPHA合成或作用抑制剂的新药物组合物
公开(公告)号：WO2004071383A2
公开(公告)日：2004-08-26
申请号：PCT/EP2004/001141
申请日：2004-02-07
Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , MEADE, Christopher, John, Montague , PIEPER, Michael, P. , PAIRET, Michel
IPC: A61K
CPC classification number: A61K45/06 , A61K31/4164 , A61K31/46 , A61K2300/00
Abstract: The present invention relates to novel pharmaceutical compositions based on anticholinergics and TNF-alpha-antagonists, processes for preparing them and their use in the treatment of respiratory diseases.
Abstract translation: 本发明涉及基于抗胆碱能药和TNF-α拮抗剂的新型药物组合物，其制备方法及其在治疗呼吸系统疾病中的应用。
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10.发明申请NEUE ARZNEIMITTELKOMPOSITIONEN AUF DER BASIS NEUER ANTICHOLINERGIKA UND EGFR-KINASE HEMMERN 审中-公开新药组合物为主的新抗胆碱能药和EGFR激酶抑制剂
公开(公告)号：WO2004004775A1
公开(公告)日：2004-01-15
申请号：PCT/EP2003/006788
申请日：2003-06-26
Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG , PAIRET, Michel , MEADE, Christopher, John, Montague , PIEPER, Michael, P.
IPC: A61K45/06
CPC classification number: A61K9/0075 , A61K9/008 , A61K31/439 , A61K31/46 , A61K31/47 , A61K31/4745 , A61K31/505 , A61K45/06 , A61K2300/00
Abstract: Die vorliegende Erfindung betrifft neuartige Arzneimittelkompositionen auf der Basis neuer Anticholinergika und EGFR-Kinase-Hemmern, Verfahren zu deren Herstellung sowie deren Verwendung bei der Therapie von Atemwegserkrankungen.
Abstract translation: 本发明涉及基于新颖抗胆碱能药和EGFR激酶抑制剂，它们的制备和它们在呼吸疾病的治疗中使用的方法的新的药物组合物。
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