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653 条记录 (耗时 0.03 秒)

    NON-TOXIC AGENT FOR A BROAD-SPECTRUM, BACTERICIDAL OR BACTERIOSTATIC TREATMENT OF ANTIBIOTIC-RESISTANT BACTERIA IN ANIMALS
    1.
    发明申请
    NON-TOXIC AGENT FOR A BROAD-SPECTRUM, BACTERICIDAL OR BACTERIOSTATIC TREATMENT OF ANTIBIOTIC-RESISTANT BACTERIA IN ANIMALS 审中-公开
    非毒性剂用于动物中抗菌细菌的广谱，细菌或细菌治疗

    公开(公告)号：WO2015192136A1

    公开(公告)日：2015-12-17

    申请号：PCT/US2015/035842

    申请日：2015-06-15

    申请人： LIVELEAF, INC. ,  HUANG, Alexander, L. ,  WU, Gin

    发明人： HUANG, Alexander, L. ,  WU, Gin

    IPC分类号： A61K31/353 ,  A61K31/7048 ,  A61K31/7024 ,  A61P31/00

    CPC分类号： A61K33/40 ,  A61K31/192 ,  A61K31/335 ,  A61K31/353 ,  A61K31/48 ,  A61K31/7024 ,  A61K31/7032 ,  A61K2300/00

    摘要： Methods and compositions are provided for a broad-spectrum, bactericidal or bacteriostatic treatment of antibiotic-resistant bacteria in animals with a non-toxic agent. The teachings include bactericidal or bacteriostatic treatment of spore-forming, anaerobic antibiotic-resistant bacteria. And, the compositions and methods provided herein can at least inhibit the onset of, inhibit the growth of, inhibit the germination of, or kill the antibiotic-resistant bacteria. Suchantibiotic-resistant bacteria include, but are not limited to, Clostridium difficile , Enterococcus faecalis, Staphylococcus aureus , and Klebsiella pneumoniae.

    摘要翻译： 提供了方法和组合物，用于在具有无毒剂的动物中进行广谱，杀菌或抑菌处理抗生素抗性细菌。 该教导包括对孢子形成，厌氧抗生素抗性细菌的杀菌或抑菌处理。 而且，本文提供的组合物和方法可以至少抑制抑制抗生素抗性细菌的发芽或抑制抗生素抗性细菌的发生，抑制生长。 这种抗生素抗性细菌包括但不限于艰难梭菌，粪肠球菌，金黄色葡萄球菌和肺炎克雷伯杆菌。

    TREATMENT OF DRUG ABUSE BY PREVENTING GAPDH NITROSYLATION
    4.
    发明申请
    TREATMENT OF DRUG ABUSE BY PREVENTING GAPDH NITROSYLATION 审中-公开
    通过预防GAPDH NITROSYLATION治疗药物滥用

    公开(公告)号：WO2014120885A1

    公开(公告)日：2014-08-07

    申请号：PCT/US2014/013775

    申请日：2014-01-30

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： SNYDER, Solomon H. ,  SEN, Nilkantha ,  XU, Risheng

    IPC分类号： A61K31/335 ,  A61P25/28 ,  A61P25/00

    CPC分类号： A61K31/335 ,  A61K31/137 ,  G01N33/573 ,  G01N2333/90203 ,  G01N2500/02

    摘要： The present invention relates to the field of drug abuse. More specifically, the present invention provides methods and compositions for treating drug abuse by preventing GAPDH nitrosylation. In one specific embodiment, a method for preventing the stimulant and neurotoxic effects of cocaine comprises the step of administering a compound that prevents the nitrosylation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by nitric oxide (NO). In another embodiment, a method for preventing the stimulant and neurotoxic effects of cocaine comprises the step of administering a compound that prevents the binding of GAPDH to Siah.

    摘要翻译： 本发明涉及药物滥用领域。 更具体地说，本发明提供了通过防止GAPDH亚硝化来治疗药物滥用的方法和组合物。 在一个具体实施方案中，用于预防可卡因的兴奋剂和神经毒性作用的方法包括施用防止一氧化氮（NO）对甘油醛-3-磷酸脱氢酶（GAPDH）进行亚硝基化的化合物的步骤。 在另一个实施方案中，用于预防可卡因的兴奋剂和神经毒性作用的方法包括施用防止GAPDH与Siah结合的化合物的步骤。

    BITTER TASTE MASKED PHARMACEUTICAL FORMULATION COMPRISING CORTICOSTEROID, ANTIHISTAMINE AND STEVIA
    5.
    发明申请
    BITTER TASTE MASKED PHARMACEUTICAL FORMULATION COMPRISING CORTICOSTEROID, ANTIHISTAMINE AND STEVIA 审中-公开
    BITTER TASTE MASKED PHARMACEUTICAL FORMULATION COMPRISING CORTICOSTEROID，ANTIHISTAMINE AND STEVIA

    公开(公告)号：WO2014092346A1

    公开(公告)日：2014-06-19

    申请号：PCT/KR2013/010417

    申请日：2013-11-15

    申请人： HANMI PHARM. CO., LTD.

    发明人： KIM, Jin Cheul ,  KIM, Jae Ho ,  KIM, Yo Han ,  KIM, Yong Il ,  PARK, Jae Hyun ,  WOO, Jong Soo

    IPC分类号： A61K31/573 ,  A61K31/335 ,  A61P11/02

    CPC分类号： A61K31/55 ,  A61K9/0043 ,  A61K31/335 ,  A61K31/56 ,  A61K31/58 ,  A61K2300/00

    摘要： The present invention relates to a bitter taste masked pharmaceutical formulation comprising: (i) corticosteroid or a pharmaceutically acceptable salt thereof; (ii) an antihistamine selected from the group consisting of olopatadine, azelastine and a pharmaceutically acceptable salt thereof; and (iii) stevia. The pharmaceutical formulation according to the present invention effectively blocks bitter taste of the active ingredients, thereby having improved taste and patient compliance, and thus can be efficiently used in the treatment of allergic rhinitis.

    摘要翻译： 本发明涉及苦味掩蔽的药物制剂，其包含：（i）皮质类固醇或其药学上可接受的盐; （ii）选自奥洛他定，氮卓斯汀及其药学上可接受的盐的抗组胺剂; 和（iii）甜叶菊。 根据本发明的药物制剂有效地抑制了活性成分的苦味，从而具有改善的味道和患者依从性，因此可以有效地用于治疗过敏性鼻炎。

    MIXED MONOAMINE REUPTAKE INHIBITOR IN A BIODEGRADABLE POLYMER CARRIER
    9.
    发明申请
    MIXED MONOAMINE REUPTAKE INHIBITOR IN A BIODEGRADABLE POLYMER CARRIER 审中-公开
    可生物降解聚合物载体中的混合单胺反应抑制剂

    公开(公告)号：WO2013126205A1

    公开(公告)日：2013-08-29

    申请号：PCT/US2013/024717

    申请日：2013-02-05

    申请人： WARSAW ORTHOPEDIC, INC.

    发明人： WILSEY, Jared T.

    IPC分类号： A61K47/48 ,  A61K47/30 ,  A61K31/135 ,  A61K31/13 ,  A61P25/24

    CPC分类号： A61K31/135 ,  A61K9/0024 ,  A61K31/335 ,  A61K31/381 ,  A61K45/06 ,  A61K2300/00

    摘要： Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of mixed monoamine reuptake inhibitor locally at or near a target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation ( i.e. sciatica), spondilothesis, stenosis, discogenic back pain and joint pain, as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least thirty days. In some embodiments, the relief can be for at least at least fifty days, at least one hundred days, at least one hundred and twenty days, at least one hundred and thirty, at least one hundred fifty days or at least one hundred and eighty days.

    摘要翻译： 提供长时间有效的疼痛治疗。 通过在目标部位处或附近局部施用有效量的混合单胺再摄取抑制剂，可以缓解由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，椎间盘背痛和 关节疼痛以及手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少30天。 在一些实施例中，浮雕可以是至少至少五十天，至少一百天，至少一百二十天，至少一百三十，至少一百五十天，或至少一百八十 天。