公开(公告)号：WO2010070511A3

公开(公告)日：2011-10-13

申请号：PCT/IB2009055414

申请日：2009-11-30

Applicant: ALEMBIC LTD ,  PONNAIAH RAVI ,  PRASAD ASHOK ,  PANCHASARA DINESHKUMAR RAMABHAI ,  CHAVAN GAJANAN JIJABA ,  PRAJAPATI BHAVESH HARESHBHAI ,  PATEL ILESH MAHENDRABHAI

Inventor： PONNAIAH RAVI ,  PRASAD ASHOK ,  PANCHASARA DINESHKUMAR RAMABHAI ,  CHAVAN GAJANAN JIJABA ,  PRAJAPATI BHAVESH HARESHBHAI ,  PATEL ILESH MAHENDRABHAI

IPC: C07D211/02 ,  C07D211/32 ,  C07D211/70

CPC classification number: C07D211/02 ,  C07D211/32 ,  C07D211/70

Abstract: The present invention relates to a process for the preparation of donepezil hydrochloride o formula (I) which comprises the steps of condensing a pyridinium bromide salt of formula (IV) with dimethoxy-indanone of formula (V) and reducing the resulting condensed bromide salt of formula (VI) in two steps. The present invention further relates to a di-ene intermediate of formula (VII).

Abstract translation: 本发明涉及式（I）的盐酸多奈哌齐的制备方法，该方法包括将式（Ⅳ）的溴化吡啶鎓盐与式（Ⅴ）的二甲氧基 - 二氢茚缩合并将所得的缩合溴化物盐 式（VI）分两步进行。 本发明还涉及式（Ⅶ）的二烯中间体。

公开(公告)号：WO2010070511A2

公开(公告)日：2010-06-24

申请号：PCT/IB2009/055414

申请日：2009-11-30

Applicant: ALEMBIC LIMITED ,  PONNAIAH, Ravi ,  PRASAD, Ashok ,  PANCHASARA, Dineshkumar Ramabhai ,  CHAVAN, Gajanan Jijaba ,  PRAJAPATI, Bhavesh Hareshbhai ,  PATEL, Ilesh Mahendrabhai

Inventor： PONNAIAH, Ravi ,  PRASAD, Ashok ,  PANCHASARA, Dineshkumar Ramabhai ,  CHAVAN, Gajanan Jijaba ,  PRAJAPATI, Bhavesh Hareshbhai ,  PATEL, Ilesh Mahendrabhai

IPC: C07D211/02

CPC classification number: C07D211/02 ,  C07D211/32 ,  C07D211/70

Abstract: The present invention relates to novel process for preparing Donepezil hydrochloride of formula (I)

Abstract translation: 本发明涉及制备式（I）的盐酸多奈哌齐的新方法，