公开(公告)号：WO2012153349A2

公开(公告)日：2012-11-15

申请号：PCT/IN2012000329

申请日：2012-05-04

Applicant: CADILA HEALTHCARE LTD ,  DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  PATEL MAYUR RAMNIKBHAI

Inventor： DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  PATEL MAYUR RAMNIKBHAI

IPC: C07C211/42

CPC classification number: C07C211/42 ,  C07B2200/13 ,  C07C309/29 ,  C07C309/35

Abstract: The present invention relates to Rasagiline acid addition salts having a particle size D(90) greater than 250 microns and D(50) greater than 100 microns, with the proviso that acid addition salt is not mesylate. The invention also discloses a process for the preparation of such Rasagiline acid addition salts.

Abstract translation: 本发明涉及粒度D（90）大于250微米，D（50）大于100微米的雷沙吉兰酸加成盐，条件是酸加成盐不是甲磺酸盐。 本发明还公开了制备这种雷沙吉兰加成盐的方法。

公开(公告)号：WO2012046250A8

公开(公告)日：2012-11-15

申请号：PCT/IN2011000695

申请日：2011-10-05

Applicant: CADILA HEALTHCARE LTD ,  DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  ROY RUSHIKESH UDAYKUMAR

Inventor： DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  ROY RUSHIKESH UDAYKUMAR

IPC: C07C215/64 ,  A61K31/137 ,  A61P25/24 ,  C07C55/10

CPC classification number: C07C215/64 ,  A61K31/137 ,  C07B2200/13 ,  C07C55/10 ,  C07C2601/14

Abstract: The present invention discloses polymorphic forms of O-desmethyl-venlafaxine succinate and processes for the preparation thereof.

Abstract translation: 本发明公开了O-去甲基 - 文拉法辛琥珀酸酯的多晶型物及其制备方法。

公开(公告)号：WO2012025941A3

公开(公告)日：2012-10-11

申请号：PCT/IN2011000575

申请日：2011-08-25

Applicant: CADILA HEALTHCARE LTD ,  DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  JAIN KULDEEP NATWARLAL

Inventor： DWIVEDI SHRIPRAKASH DHAR ,  PRASAD ASHOK ,  JAIN KULDEEP NATWARLAL

IPC: C07C219/28 ,  C07C57/15 ,  C07C59/56 ,  C07C69/96 ,  C07C213/10 ,  C07C215/54 ,  C07C217/62

CPC classification number: C07C219/28 ,  C07B2200/07 ,  C07B2200/13 ,  C07C41/26 ,  C07C51/43 ,  C07C59/56 ,  C07C67/03 ,  C07C213/00 ,  C07C213/06 ,  C07C213/08 ,  C07C213/10 ,  C07C217/62 ,  C07C303/28 ,  C07C309/66 ,  C07C309/67 ,  C07C215/54 ,  C07C43/23 ,  C07C69/734

Abstract: The invention relates to improved process for the preparation of fesoterodine and its pharmaceutically acceptable salt, specifically fesoterodine fumarate of formula (1). The invention relates to solid state forms of a novel salt of fesoterodine and process for the preparation thereof. The invention also relates to highly pure fesoterodine fumarate substantially free of impurity X at RRT 1.37. The invention also provides solid particles of pure fesoterodine fumarate wherein 90 volume-percent of the particles (D90) have a size of higher than 200 microns.

Abstract translation: 本发明涉及制备非索特罗及其药学上可接受的盐，特别是式（1）的富马酸弗索塔罗汀的改进方法。 本发明涉及非索罗定新型盐的固态形式及其制备方法。 本发明还涉及在RRT 1.37基本上不含杂质X的高纯度富马酸菲索特罗。 本发明还提供富马酸纯的富特罗定的固体颗粒，其中90体积％的颗粒（D90）具有高于200微米的尺寸。

公开(公告)号：WO2012046250A2

公开(公告)日：2012-04-12

申请号：PCT/IN2011/000695

申请日：2011-10-05

Applicant: CADILA HEALTHCARE LIMITED ,  DWIVEDI, Shriprakash Dhar ,  PRASAD, Ashok ,  ROY, Rushikesh Udaykumar

Inventor： DWIVEDI, Shriprakash Dhar ,  PRASAD, Ashok ,  ROY, Rushikesh Udaykumar

IPC: C07C215/64

CPC classification number: C07C215/64 ,  A61K31/137 ,  C07B2200/13 ,  C07C55/10 ,  C07C2601/14

Abstract: The present invention discloses polymorphic forms of O-desmethyl-venlafaxine succinate and processes for the preparation thereof.

Abstract translation: 本发明公开了O-去甲基 - 文拉法辛琥珀酸酯的多晶型物及其制备方法。

公开(公告)号：WO2011121607A2

公开(公告)日：2011-10-06

申请号：PCT/IN2011/000213

申请日：2011-03-29

Applicant: CADILA HEALTHCARE LIMITED ,  DWIVEDI, Shriprakash, Dhar ,  PRASAD, Ashok ,  PATEL, Mayur, Ramnikbhai

Inventor： DWIVEDI, Shriprakash, Dhar ,  PRASAD, Ashok ,  PATEL, Mayur, Ramnikbhai

IPC: C07C211/42 ,  A61K31/135 ,  A61P25/00

CPC classification number: C07C211/42 ,  C07C2602/08

Abstract: The present invention relates to rasagiline (I) and its pharmaceutically acceptable salts. The invention also relates to improved processes for the preparation of rasagiline and its pharmaceutically acceptable salts. The invention also relates to pharmaceutical compositions that include the pharmaceutically acceptable salts of rasagiline and use of the compositions for treating the signs and symptoms of idiopathic Parkinson's disease as initial monotherapy and as adjunct therapy to levodopa.

Abstract translation: 本发明涉及雷沙吉兰（I）及其药学上可接受的盐。 本发明还涉及制备雷沙吉兰及其药学上可接受的盐的改进方法。 本发明还涉及药物组合物，其包括雷沙吉兰的药学上可接受的盐，以及组合物用于治疗特发性帕金森病的体征和症状的初始单一疗法和作为左旋多巴的辅助治疗的药物组合物。

公开(公告)号：WO2010029458A3

公开(公告)日：2011-01-27

申请号：PCT/IB2009053760

申请日：2009-08-28

Applicant: ALEMBIC LTD ,  DEO KESHAV ,  PRASAD ASHOK ,  PANCHASARA DINESH

Inventor： DEO KESHAV ,  PRASAD ASHOK ,  PANCHASARA DINESH

IPC: C07D417/04

CPC classification number: C07D417/04 ,  C07D281/16

Abstract: The present invention relates to a process for preparing Quetiapine fumarate of formula (I)

Abstract translation: 本发明涉及一种制备式（I）富马酸喹硫平的方法，

公开(公告)号：WO2011004298A1

公开(公告)日：2011-01-13

申请号：PCT/IB2010/053041

申请日：2010-07-02

Applicant: ALEMBIC LIMITED ,  PONNAIAH, Ravi ,  PRASAD, Ashok ,  TALUKDAR, Sanjay ,  PATEL, Killol ,  ACHARYA, Hitarth, Harshendu ,  PARMAR, Jitendra

Inventor： PONNAIAH, Ravi ,  PRASAD, Ashok ,  TALUKDAR, Sanjay ,  PATEL, Killol ,  ACHARYA, Hitarth, Harshendu ,  PARMAR, Jitendra

IPC: C07D215/18

CPC classification number: C07D215/18

Abstract: The present invention relates to a montelukast hexamethylenediamine, Formule (I). It also relates to a process for the preparation of montelukast hexamethylenediamine and its use for the preparation of Montelukast Sodium.

Abstract translation: 本发明涉及孟鲁司特六亚甲基二胺（Formule（I））。 它还涉及制备孟鲁司特六亚甲基二胺的方法及其制备孟鲁司特钠的用途。

公开(公告)号：WO2010079404A2

公开(公告)日：2010-07-15

申请号：PCT/IB2009/055958

申请日：2009-12-28

Applicant: ALEMBIC LIMITED ,  PONNAIAH, Ravi ,  PRASAD, Ashok ,  PATEL, Killol ,  ACHARYA, Hitarth Harshendu ,  KATORE, Vilas ,  SHAH, Bhavik

Inventor： PONNAIAH, Ravi ,  PRASAD, Ashok ,  PATEL, Killol ,  ACHARYA, Hitarth Harshendu ,  KATORE, Vilas ,  SHAH, Bhavik

IPC: C07D333/20

CPC classification number: C07D333/20

Abstract: The present invention relates to improved process for the preparation of Duloxetine of formula (I) and salts thereof wherein said improvement takes place in step of condensation.

Abstract translation: 本发明涉及制备式（I）的度洛西汀及其盐的改进方法，其中所述改进发生在缩合步骤中。

公开(公告)号：WO2010029458A2

公开(公告)日：2010-03-18

申请号：PCT/IB2009/053760

申请日：2009-08-28

Applicant: ALEMBIC LIMITED ,  DEO, Keshav ,  PRASAD, Ashok ,  PANCHASARA, Dinesh

Inventor： DEO, Keshav ,  PRASAD, Ashok ,  PANCHASARA, Dinesh

IPC: C07D417/04

CPC classification number: C07D417/04 ,  C07D281/16

Abstract: The present invention relates to a process for preparing Quetiapine fumarate of formula (I)

Abstract translation: 本发明涉及一种制备式（I）富马酸喹硫平的方法，

公开(公告)号：WO2009156938A2

公开(公告)日：2009-12-30

申请号：PCT/IB2009/052666

申请日：2009-06-22

Applicant: ALEMBIC LIMITED ,  DEO, Keshav ,  PRASAD, Ashok ,  GANDHI, Mitesh ,  PATIL, Dattatraya

Inventor： DEO, Keshav ,  PRASAD, Ashok ,  GANDHI, Mitesh ,  PATIL, Dattatraya

IPC: C07H17/08

CPC classification number: C07H17/08 ,  Y02P20/582

Abstract: The present invention relates to an improved process for the preparation of 6,9-imino ether of formula (I) an intermediate used in preparation of Azithromycin. The present invention further provides a process for preparation of Azithromycin.

Abstract translation: 本发明涉及制备用于制备阿奇霉素的中间体的式（I）的6,9-亚氨基醚的改进方法。 本发明还提供了制备阿奇霉素的方法。